Bai-Yao Wu

Zosteriform Porokeratosis of Mibelli

Porokeratosis is a distinct skin disorder thought to be caused by a clonal dyshomeostasis of epidermal keratinization. It is characterized by single to multiple fl at or atrophic patches surrounded by a clinically and histologically distinctive hyperkeratotic border, so-called cornoid lamella. Several clinical variants have been identified. Herein, we reported a 27-yearold male showing a strikingly vivid zosteriform dermatosis that is histologically consistent with the diagnosis of porokeratosis. Zosteriform porokeratosis of Mibelli is an extremely rare presentation of porokeratosis and should be carefully differentiated from other linear dermatosis.

Sporotrichoid Chromoblastomycosis Successfully Treated by Combinative Therapy with Systemic Oral Antifungal Agent and Topical Cryotherapy

Chromoblastomycosis is a chronic persistent fungal infection which affects the skin and subcutaneous tissue. It is an occupation-associated fungal infection and exhibits a high prevalence rate in tropical and subtropical regions. Targeting the chronic progression of granulomatous inflammation, the single-treatment modality usually encounters difficulty and is accompanied by serious side effects. Herein we reported a patient who had multiple well-circumscribed erythmatous hypertrophic plaques with several satellite papules on the right elbow for 5 years and the diagnosis of chromoblastomycosis was confirmed by skin biopsy and fungal culture. The lesions were eradicated with the combined administration of oral itraconazole and liquid nitrogen cryotherapy for half a year. This case report is meant to suggest the use of combinative therapy for patients with intractable chromoblastomycotic infection.

ALDH1A1 and ALDH3A1 Expression of Melanocytic Neoplasms and Associated with Clinicopathological Parameters in Chinese People

Background: ALDH1A1 and ALDH3A1 were reported to be highly expressed in some cancerous tissues. The aim of this study was to assess ALDH1A1 and ALDH3A1 expression and cellular localization in a spectrum of melanocytic lesions, ranging from common melanocytic nevi (CMN) and dysplastic nevi (DN) to acral melanoma (AM). We also compared the clinicopathological correlation of AM in a large Chinese population. Material and Methods: We used purified classspecific antibodies against ALDH1A1 and ALDH3A1 to elucidate the cellular distribution of these proteins in a human tissue microarray derived from 20 patients with CMN, 12 patients with DN, and 80 patients with primary acral MM. The cytoplasmic immunostaining score was obtained by multiplying the percentage of antigen-positive cells by their average immunostaining intensity. Mean ± S.E.M. for each experimental group was calculated and compared. The relationships between AJCC TNM stage and cytoplasmic scores of ALDH1A1 and ALDH3A1 were examined. Results: A statistically higher score for ALDH1A1 staining was noted in CMN than in DN (p＜0.028). ALDH3A1 staining was significantly different between CMN and AM. No statistical differences in survival and no association between cytoplasmic staining of both enzymes and other clinical parameters were demonstrated. Conclusion: ALDH1A1 and ALDH3A1 were differentially expressed in CMN, DN, and AM; yet, these enzymes may not be appropriate for use as prognostic factors.

Asymptomatic whitish papules over both arms in a 28‐year‐old woman

A 28-year-old woman presented with a 5-year history of asymptomatic lesions on her arms and upper back, which had been gradually increasing in number. The patient was otherwise healthy, and there was no history of previous trauma or preceding inflammatory dermatosis on the involved areas; however, no other medical records could be traced. On physical examination, numerous, round, white, asymptomatic, nonfollicular, papules measuring 1–2 mm in diameter were seen on the proximal surfaces of both arms and on the upper back (Fig. 1). These lesions were slightly indurated on palpation. Radiography of the patient’s right wrist did not show any abnormality. Histopathological findings