Balasundara Raju

Ultrasound mediated drug delivery

For patients with ulcerative colitis, the most common form of inflammatory bowel disease (IBD), aminosalicylates such as mesalamine provide first line anti-inflammatory therapy. Since efficacy is related to tissue concentration, when administered as a rectal enema lack of retention challenges topical formulation effectiveness. To address this problem, Schoellhammer and his colleagues (Schoellhammer et al 2015) recently described the development and pre-clinical testing of a novel delivery system in which they incorporated low frequency ultrasound (LFU) as a means to enhance transmucosal drug delivery through the gastrointestinal mucosa.