Balázs Blazics
Semmelweis University
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Publication
Featured researches published by Balázs Blazics.
Molecular Pharmaceutics | 2013
Katalin Prokai-Tatrai; Hua Xin; Vien Nguyen; Szabolcs Szarka; Balázs Blazics; Laszlo Prokai; Peter Koulen
Neuroprotection in glaucoma as a curative strategy complementary to current therapies to lower intraocular pressure (IOP) is highly desirable. This study was designed to investigate neuroprotection by 17β-estradiol (E2) to prevent retinal ganglion cell (RGC) death in a glaucoma model of surgically elevated IOP in rats. We found that daily treatment with E2-containing eye drops resulted in significant E2 concentration in the retina with concomitant profound neuroprotective therapeutic benefits, even in the presence of continually elevated IOP. The number of apoptotic cells in the RGC layer was significantly decreased in the E2-treated group, when compared to the vehicle-treated controls. Deterioration in visual acuity in these animals was also markedly prevented. Using mass spectrometry-based proteomics, beneficial changes in the expression of several proteins implicated in the maintenance of retinal health were also found in the retina of E2-treated animals. On the other hand, systemic side effects could not be avoided with the eye drops, as confirmed by the measured high circulating estrogen levels and through the assessment of the uterus representing a typical hormone-sensitive peripheral organ. Collectively, the demonstrated significant neuroprotective effect of topical E2 in the selected animal model of glaucoma provides a clear rationale for further studies aiming at targeting E2 into the eye while avoiding systemic E2 exposure to diminish undesirable off-target side effects.
Orvosi Hetilap | 2012
Tatjána Ábel; Anna Blázovics; Alexandra Wimmer; Gabriella Bekő; Balázs Gaál; Balázs Blazics; Mohamed Gamal Eldin; János Fehér; Gabriella Lengyel
UNLABELLED Moderate alcohol consumption has been associated with decreased cardiovascular mortality in the general population. Relatively few studies have been conducted to evaluate the effect of white wine on insulin sensitivity. AIMS The authors studied the impact of moderate Pintes white wine consumption on insulin sensitivity and other metabolic parameters. METHODS The prospective study involved 18 patients with metabolic syndrome. The patients consumed Pintes white wine for 4 weeks, and parameters were measured before and after consumption. RESULTS The HOMA-IR decreased significantly after white wine consumption (2.28±2.04 vs 1.08±0.6; p = 0.002). There were no changes in serum cholesterol, LDL-cholesterol, triglyceride and fasting plasma glucose levels. CONCLUSION White wine consumption improved insulin sensitivity in patients with metabolic syndrome.
Journal of Pharmaceutical and Biomedical Analysis | 2009
Barbara Hevesi Tóth; Balázs Blazics; Ágnes Kéry
European Journal of Lipid Science and Technology | 2012
Szabina Plánder; Lenuta Gontaru; Balázs Blazics; Katalin Veres; Ágnes Kéry; Sabine Kareth; Béla Simándi
Journal of Supercritical Fluids | 2012
Anikó Felföldi-Gáva; Szabolcs Szarka; Béla Simándi; Balázs Blazics; Blanka Simon; Ágnes Kéry
Journal of Chromatographic Science | 2011
Balázs Blazics; Ágnes Alberti; Szabolcs Béni; László Kursinszki; László Tölgyesi; Ágnes Kéry
Fitoterapia | 2012
Andrea Balázs; Magdolna Tóth; Balázs Blazics; Éva Héthelyi; Szabolcs Szarka; Emese Ficsor; Gitta Ficzek; Éva Lemberkovics; Anna Blázovics
Chromatographia | 2008
Ágnes Alberti; Balázs Blazics; Ágnes Kéry
Chromatographia | 2010
Balázs Blazics; Ildikó Papp; Ágnes Kéry
Acta pharmaceutica Hungarica | 2009
Balázs Blazics; Ágnes Alberti; Ágnes Kéry