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Bangping Xiang

Merck & Co.

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Featured researches published by Bangping Xiang.

Organic Letters | 2014

Unusual Pyrimidine Participation: Efficient Stereoselective Synthesis of Potent Dual Orexin Receptor Antagonist MK-6096

John Chung; Yong-Li Zhong; Kevin M. Maloney; Robert A. Reamer; Jeffrey C. Moore; Hallena Strotman; Alexei Kalinin; Ronnie Feng; Neil A. Strotman; Bangping Xiang; Nobuyoshi Yasuda

An asymmetric synthesis of dual orexin receptor antagonist MK-6096 (1) is described. Key steps for the trans-2,5-disubstituted piperidinyl ether fragment include a biocatalytic transamination, a trans-selective Mukaiyama aldol, and a regioselective pyridyl SNAr process. The pyrimidyl benzoic acid was synthesized via a Negishi coupling and a nitrile hydrolysis. Coupling of the two fragments via a catalytic T3P-mediated amidation completed the synthesis. Unusual behaviors in the hydrolysis of pyrimidyl benzonitrile and the amide coupling of the pyrimidyl benzoic acid are also described.

Journal of Organic Chemistry | 2007

A General and Efficient 2-Amination of Pyridines and Quinolines

Jingjun Yin; Bangping Xiang; Mark A. Huffman; Conrad E. Raab; Ian W. Davies

Organic Process Research & Development | 2010

Enantioselective Synthesis of (1R,2S)-1-Amino-2-vinylcyclopropanecarboxylic Acid Ethyl Ester (Vinyl-ACCA-OEt) by Asymmetric Phase-Transfer Catalyzed Cyclopropanation of (E)-N-Phenylmethyleneglycine Ethyl Ester

Kevin M. Belyk; Bangping Xiang; Paul G. Bulger; William R. Leonard; Jaume Balsells; Jingjun Yin; Cheng-yi Chen

Angewandte Chemie | 2014

Discovery and Application of Doubly Quaternized Cinchona-Alkaloid-Based Phase-Transfer Catalysts†

Bangping Xiang; Kevin M. Belyk; Robert A. Reamer; Nobuyoshi Yasuda

Tetrahedron | 2009

Development of practical syntheses of potent non-nucleoside reverse transcriptase inhibitors

Jeffrey T. Kuethe; Yong-Li Zhong; Mahbub Alam; Anthony Alorati; Gregory L. Beutner; Dongwei Cai; Fred J. Fleitz; Andrew D. Gibb; Amude Kassim; Kathleen Linn; Danny Mancheno; Benjamin Marcune; Philip J. Pye; Jeremy P. Scott; David M. Tellers; Bangping Xiang; Nobuyoshi Yasuda; Jingjun Yin; Ian W. Davies

Organic Process Research & Development | 2016

Asymmetric Synthesis of Letermovir Using a Novel Phase-Transfer-Catalyzed Aza-Michael Reaction

Guy R. Humphrey; Stephen Mark Dalby; Teresa Andreani; Bangping Xiang; Michael R. Luzung; Zhiguo Jake Song; Michael Shevlin; Melodie Christensen; Kevin M. Belyk; David M. Tschaen

Organic Process Research & Development | 2017

Practical Asymmetric Synthesis of a Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist Ubrogepant

Nobuyoshi Yasuda; Ed Cleator; Birgit Kosjek; Jianguo Yin; Bangping Xiang; Frank Chen; Shen-Chun Kuo; Kevin M. Belyk; Peter R. Mullens; Adrian Goodyear; John S. Edwards; Brian Bishop; Scott S. Ceglia; Justin Belardi; Lushi Tan; Zhiguo Jake Song; Lisa DiMichele; Robert A. Reamer; Fabien L. Cabirol; Weng Lin Tang; Guiquan Liu

Archive | 2015

PROCESS FOR MAKING SUBSTITUTED QUINAZOLINE COMPOUNDS

Michael R. Luzung; Guy R. Humphrey; Bangping Xiang; Kevin M. Belyk; Stephen Mark Dalby; Wilfried Schwab; Burkhard Klenke; Tom Moody; Gareth Brown

Archive | 2013

BIS-QUARTERNARY CINCHONA ALKALOID SALTS AS ASYMMETRIC PHASE TRANSFER CATALYSTS

Bangping Xiang; Nobuyoshi Yasuda

Archive | 2016

Procédé de préparation de composés hétérocycliques tétracycliques substitués

Jingjun Yin; Tetsuji Itoh; Jianguo Yin; Bangping Xiang; Kevin R. Campos; Alexei Kalinin; Zhuqing Liu; Melodie Christensen; Kevin M. Belyk; Richard J. Varsolona; Andrew Brunskill

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Kevin M. Belyk

University of Michigan

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Nobuyoshi Yasuda

Merck

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Jingjun Yin

Merck

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Jianguo Yin

Schering-Plough

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Alexei Kalinin

Merck

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Melodie Christensen

Merck

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Robert A. Reamer

Merck

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Andrew Brunskill

Merck

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Guy R. Humphrey

Merck

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Ian W. Davies

Merck

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