Banu Aktas Yilmaz

Elevated mean platelet volume is associated with gestational diabetes mellitus

Abstract The mean platelet volume (MPV) is an indicator of the average size and activity of platelets. Elevated MPV values are associated with larger and more active platelets and perceived as a new independent cardiovascular risk factor. The aim of this study was to determine the MPV in women with gestational diabetes mellitus (GDM) and to determine the correlation of MPV with metabolic parameters in GDM. We retrospectively analyzed 30 women with GDM and 38 body mass index-matched women with healthy pregnancies as controls. MPV and platelet counts were recorded in the third trimester and at postpartum 6–12 months for GDM group and in the third trimester for control group. Third-trimester MPV was significantly higher in GDM group compared to control group (8.8 ± 1.0 versus 8.1 ± 0.7 fl, p = 0.002). In women with GDM, there was a significant decrease in MPV in the postpartum period (8.8 ± 1.0 versus 8.1 ± 0.8 fl, p < 0.001). Fasting plasma glucose levels and glucose area under the curve were positively correlated with third trimester MPV (r = 0.346, p = 0.007 and r = 0.346, p = 0.02, respectively). Our results indicate that MPV is increased in GDM. Monitoring MPV, which is widely available in clinical practice, may potentially identify women who will develop gestational diabetes during pregnancy. Chinese abstract 平均血小板体积（MPV）是测量血小板平均体积与活性的指标。MPV值升高预示着血小板体积增大、活性增加，被认为是一种新的独立心血管风险因子。本研究的目的在于测定妊娠糖尿病（GDM）女性的MPV水平，确定MPV与GDM中代谢参数的关系。我们回顾性分析了30名GDM女性，且设立对照组为38名身体质量指数相匹配的健康妊娠女性。GDM组分别在妊娠末期与产后6∼12个月记录MPV值与血小板计数，而对照组仅在妊娠末期测量。在妊娠末期，GDM组的MPV显著高于对照组（8.8±1.0 VS 8.1±0.7 fl, p = 0.002）。GDM患者的MPV水平在产后显著下降（8.8±1.0 VS 8.1±0.8 fl, p < 0.001）。空腹血糖水平与曲线下血糖面积与妊娠末期MPV密切相关（分别为r = 0.346, p = 0.007与r = 0.346, p = 0.02）。本研究的结果表明MPV水平在GDM患者中升高。MPV在临床应用中的测量十分普遍，监测MPV也许可以潜在地鉴别出有妊娠期糖尿病发病趋势的女性。