Barbara C. Stahly

Screening strategies based on solubility and solution composition generate pharmaceutically acceptable cocrystals of carbamazepine

Four different screening techniques were used to form cocrystals of carbamazepine containing pharmaceutically acceptable carboxylic acids. Twenty-seven unique solid phases utilizing eighteen carboxylic acid coformers were generated in the screening experiments. Cocrystal formation and stability in water is reported. Phase solubility diagrams and triangular phase diagrams are used to illustrate how saturation of the reactants leads to supersaturation of the cocrystal.

New solid-state chemistry technologies to bring better drugs to market: knowledge-based decision making

Modern drug development demands constant deployment of more effective technologies to mitigate the high cost of bringing new drugs to market. In addition to cost savings, new technologies can improve all aspects of pharmaceutical development. New technologies developed at SSCI, Inc. include solid form development of an active pharmaceutical ingredients. (APIs) are PatternMatch software and capillary-based crystallisation techniques that not only allow for fast and effective solid form screening, but also extract maximum property information from the routine screening data that is generally available. These new technologies offer knowledge-based decision making during solid form development of APIs and result in more developable API solid forms.