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Dive into the research topics where Barbara J. Whitlock is active.

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Featured researches published by Barbara J. Whitlock.


Archives of Biochemistry and Biophysics | 1963

α-Methylvaleric acid from Ascaris lumbricoides☆

Barbara J. Whitlock; F.M. Strong

Abstract A reinvestigation of the C 6 volatile fatty acid from Ascaris lumbricoides supports the structure α-methylvaleric rather than isocaproic acid for this product.


Tetrahedron Letters | 1988

Intracavity acetyl transfer

Barbara J. Whitlock; Howard W. Whitlock

Abstract Synthesis of water soluble cyclophane 1 , designed as an esterase mimic is described. Cyclophane 1 is an effective acetyl acceptor, from water soluble acetylating agents capable of intracavity complexation.


Archive | 1995

Design of Host Molecules Capable of Forming Extremely Stable Host-Guest Complexes

Barbara J. Whitlock; Howard W. Whitlock

Construction of extremely sticky host molecules, those capable of forming extremely stable complexes with suitable guests, is an interesting and important puzzle. The more important “design principles” for this class of compound are summarized: Hydrophobic complexation, as illustrated by the cyclodextrins, is historically the first and “defining” force in host-guest complex stabilization.1 Its great importance to biological systems has caused it to be the subject of intense scrutiny. While originally ascribed to entropie effects2 current thinking is revisionist in ascribing it primarily to enthalpic features of the hydrogen bond and differential solvation of host and guest.3 A particularly illuminating series of papers by Diederich summarizes the arguments for this viewpoint.4 The rather amorphous nature of hydrophobic effects is accented by Dougherty’s work on the importance of ion-dipole effects in several anthracenophane-based hosts. The hydrogen bond has been exploited to great effect in the design of hosts capable of acting primarily in aprotic organic solvents.5 Aromatic-aromatic stacking has been exploited by Rebek, Hamilton and others in building nucleoside binding hosts.6 The “lock and key effect”, refined as Cram’s preorganization concept has received increasing consideration7 recently in the context of immunophilin binding studies. Edge-face aromatic-aromatic interactions have been advanced as a stabilizing force on protein conformations. In favorable cases they exercise a positive effect on complex stability. Ion-ion and ion-dipole effects have proven effective in cases studied by Dougherty8 and others. Computational tools are increasingly important in this area with respect to both the nature of solvophobic interactions and the origins of host-guest interactions.9


Journal of Organic Chemistry | 1981

Preparation and characterization of 1,8,19,26-tetraoxa[8.8](2,6)naphthalenophane-3,5,21,23-tetrayne and related donut-shaped cyclophanes

Barbara J. Whitlock; Esa T. Jarvi; Howard W. Whitlock


Journal of Organic Chemistry | 1974

Dimethyl .beta.-ketoadipate

Barbara J. Whitlock; Howard W. Whitlock


Journal of the American Chemical Society | 1985

Passage of aryl-tipped alkyl groups through molecular cavities: the role of flexibility

Barbara J. Whitlock; Howard W. Whitlock


Journal of the American Chemical Society | 1983

An experimental measure of cavity size in macrocyclic cyclophane-based host molecules

Barbara J. Whitlock; Howard W. Whitlock


Journal of Organic Chemistry | 1969

Role of solvent hydrogens in the dehydro Diels-Alder reaction

Howard W. Whitlock; E. M. Wu; Barbara J. Whitlock


Tetrahedron Letters | 1966

A salivation factor from Rhizoctonia leguminicola

Barbara J. Whitlock; D.P. Rainey; N.V. Riggs; F.M. Strong


ChemInform | 1981

PREPARATION AND CHARACTERIZATION OF 1,8,19,26-TETRAOXA(8.8)(2,6)NAPHTHALENOPHANE-3,5,21,23-TETRAYNE AND RELATED DONUT-SHAPED CYCLOPHANES

Barbara J. Whitlock; Esa T. Jarvi; Howard W. Whitlock

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Howard W. Whitlock

University of Wisconsin-Madison

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F.M. Strong

University of Wisconsin-Madison

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D.P. Rainey

University of Wisconsin-Madison

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N.V. Riggs

University of Wisconsin-Madison

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