Barbara Madej
Medical University of Lublin
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Barbara Madej.
Experimental and Toxicologic Pathology | 2002
Franciszek Burdan; Zofia Siezieniewska; Ryszard Maciejewski; Barbara Madej; Elżbieta Radzikowska; Zbigniew Wójtowicz
The aim of the study was to establish the influence of short-time omeprazole administration on liver function and morphology. Omeprazole was administered intraperitoneally, twice daily, for 3 days to male Wistar rats in two doses: 0.571 mg/kg and 5.71 mg/kg. Control animals were treated with physiological saline. Half of the animals were sacrificed 12 hours after the last injection. The remaining rats were raised for another 6 weeks, without any xenobiotics, and sacrificed on the 47th day of the experiment. The activity of free and bound fractions of hepatic acid phosphatase, beta-galactosidase, beta-N-acetyl-glucosaminidase, cathepsin B, D and L, lipase, and sulphatase were determined spectrophotometrically in homogenates of the liver. The liver sections were examined by light microscopy with hematoxylin-eosin, azan, and periodic acid-Schiff stains. Marginally significant (p < 0.1) differences in activity of free sulphatase fraction, and free and bound fractions of beta-galactosidase were found in animals exposed to the higher dose of omeprazole and sacrificed 12 hours after the last injection. Enzymatic profiles were normalised during the next 6 weeks. Histological evaluation revealed small degenerative and adaptive changes in all examined groups. It could be concluded that observed differences of hepatic lysosomal enzyme activities were the result of accompanied chemical-induced peritonitis as previously reported, and not a direct drug-toxic effect.
Annals of Agricultural and Environmental Medicine | 2016
Barbara Madej; Mateusz Szymański; Wojciech Dworzański; Ewa Dudek; Maciej Czerwonka; Wojciech Kwaśniewski
This study describes a rare case of a giant phyllodes tumor in a 13-year-old girl. The authors have conducted an analysis of the diagnostic process and have shown the results of operative treatment of the tumor. Moreover, organisational aspects of the diagnostics concerning breast diseases in patients from smaller towns in Poland have been discussed. It has been indicated that the availability of suitable diagnostics and treatment of breast diseases in children and teenagers from rural areas and smaller towns is limited.
Pharmacological Research | 2004
Franciszek Burdan; Justyna Szumiło; Robert Klepacz; Jarosław Dudka; Agnieszka Korobowicz; Edyta Tokarska; Monika Cendrowska-Pinkosz; Barbara Madej; Lidia Klepacz
Folia Morphologica | 2000
Franciszek Burdan; Barbara Madej; Zbigniew Wójtowicz; Ryszard Maciejewski; Elżbieta Radzikowska
Folia Morphologica | 2012
Franciszek Burdan; Justyna Szumiło; Jerzy A. Walocha; L. Klepacz; Barbara Madej; Wojciech Dworzański; Robert Klepacz; A. Dworzańska; E. Czekajska-Chehab; Andrzej Drop
Journal of Applied Toxicology | 2005
Jarosław Dudka; Franciszek Burdan; Justyna Szumiło; Edyta Tokarska; Agnieszka Korobowicz; Robert Klepacz; Renata Gieroba; Barbara Madej; Elżbieta Korobowicz
Experimental and Toxicologic Pathology | 2005
Ryszard Maciejewski; Franciszek Burdan; K. Burski; Barbara Madej; R. Ziemiakowicz; Andrzej Dąbrowski; Grzegorz Wallner
Folia Morphologica | 2003
Wojciech Chromiński; Barbara Madej; Ryszard Maciejewski; Kamil Torres; Roman Ciechanek; Franciszek Burdan
Folia Morphologica | 2009
Franciszek Burdan; Justyna Szumiło; Wojciech Dworzański; M. Szumiło; J. Podlodowska; K. Dyndor; Barbara Madej; J. Dworzański; Robert Klepacz
Acta Physiologica Hungarica | 2004
Jarosław Dudka; Franciszek Burdan; Barbara Madej; Justyna Szumiło; Edyta Tokarska; Agnieszka Korobowicz; Robert Klepacz; Monika Chyżyńska; Elżbieta Korobowicz