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Dive into the research topics where Barrie Martin is active.

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Featured researches published by Barrie Martin.


Bioorganic & Medicinal Chemistry Letters | 2011

Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists

Christopher Luckhurst; Linda Stein; Mark Furber; Nicola Webb; Marianne Ratcliffe; Gary Allenby; Sara Botterell; Wendy Tomlinson; Barrie Martin; Andrew Walding

Small molecule isoindoline and tetrahydroisoquinoline derivatives have been identified as selective agonists of human peroxisome proliferator-activated receptor δ (PPARδ. Compound 18 demonstrated efficacy in a biomarker for increased fatty acid oxidation, with upregulation of pyruvate dehydrogenase kinase, isozyme 4 (PDK4) in human primary myotubes.


Bioorganic & Medicinal Chemistry Letters | 2007

From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.

Brian Springthorpe; Andrew Bailey; Patrick Barton; Timothy Nicholas Birkinshaw; Roger Victor Bonnert; Roger Charles Brown; David Chapman; John Dixon; Simon D. Guile; R.G. Humphries; Simon Hunt; Francis Ince; Anthony Howard Ingall; Ian P. Kirk; Paul D. Leeson; Paul Leff; Richard J. Lewis; Barrie Martin; Dermot F. McGinnity; Michael Mortimore; Stuart W. Paine; Garry Pairaudeau; Anil Patel; Aaron Rigby; Robert J. Riley; Barry Teobald; Wendy Tomlinson; Peter J. H. Webborn; Paul Willis


Journal of Medicinal Chemistry | 2007

Optimization of monocarboxylate transporter 1 blockers through analysis and modulation of atropisomer interconversion properties.

Simon Guile; John Raymond Bantick; Martin Cooper; David Keith Donald; Christine Eyssade; Anthony Howard Ingall; Richard J. Lewis; Barrie Martin; Rukhsana T. Mohammed; Timothy J. Potter; Rachel Heulwen Reynolds; Stephen St-Gallay; Andrew D. Wright


Bioorganic & Medicinal Chemistry Letters | 2006

Potent blockers of the monocarboxylate transporter MCT1: Novel immunomodulatory compounds

Simon D. Guile; J.R. Bantick; David Cheshire; M.E. Cooper; Andrew M. Davis; David Donald; Richard Evans; C. Eyssade; D.D. Ferguson; Stephen Hill; R. Hutchinson; Anthony Howard Ingall; L.P. Kingston; Iain J. Martin; Barrie Martin; Rukhsana Mohammed; C. Murray; Matthew Perry; R.H. Reynolds; Phillip Thorne; D.J. Wilkinson; J. Withnall


Tetrahedron Letters | 2011

Molybdenum-mediated synthesis of quinazolin-4(3H)-ones via cyclocarbonylation using microwave irradiation

Bryan Roberts; David J. Liptrot; Tim Luker; Michael J. Stocks; Catherine Barber; Nicola Webb; Robert Dods; Barrie Martin


Archive | 2004

New p2x7 receptor antagonists and their use

Richard Evans; Christine Eyssade; Rhonan Ford; Barrie Martin; Toby Thompson; Paul Willis


Tetrahedron Letters | 2006

A simple and efficient synthesis of optically pure 4-alkylisoxazolidin-4-ols

Barrie Martin; Martin E. Cooper; David Donald; Simon D. Guile


Archive | 2010

New compounds 707 and their uses

Matthew Hallam; Barrie Martin; Piotr Raubo; Bryan Roberts; Stephen St-Gallay; Paul Willis


Archive | 2008

Isoquinolinone derivatives and their uses

Matthew Hallam; Barrie Martin; Piotr Raubo; Bryan Roberts; Stephen St-Gallay; Paul Willis


Archive | 2008

Novel compounds 329

Barrie Martin; Paul Willis

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Paul Willis

Loughborough University

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David Donald

Loughborough University

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