Barry A. Wexler

Bis-β,β′-conjugate addition

Abstract Addition of organocuprates to α,β-enones which possess on the β′-carbon a heteroatom substituent leads in good to excellent yield to β,β′-dialkylated ketones. This process is termed bis-β,β′-conjugate addition.

Synthesis of(±)-descarboxylquadrone

Abstract The synthesis of a biologically active anlogue of the antitumor agent quadrone, termed descarboxylquadrone ( 3 ), is described.

Acid-catalyzed rearrangements of tricyclo[4.3.2[propellane derivatives

Abstract The acid-catalyzed rearrangements of three model tricyclo[4.3.2] propellane derivatives have been explored. In each case the observed products are proposed to arise via a concerted 1,2-shift of the cyclobutane bond having an antiperiplanar alignment with the leaving group (i.e., stereoelectronic control).