Bartolo Zingone

Early and Late Outcomes of Cardiac Surgery in Octogenarians

BACKGROUND Expanding demand for cardiac surgery in the elderly requires constant assessment of selection criteria and outcomes. METHODS Records of consecutive patients 80 years old or greater (n = 355) having cardiac operations from September 1998 through May 2007 were reviewed. There were 172 isolated coronary bypass grafting (CABG), 73 isolated valve, 79 valve and CABG combined, and 31 other procedures. RESULTS Thirty-three (9.3%) deaths and 13 (3.7%) strokes occurred during the index hospital stay. Intensive care unit and hospital length of stay lasted 6.3 +/- 14.3 and 15.5 +/- 20.8 days, respectively. Overall cumulative 5-year survival was 65.5 +/- 3.3%, varying among procedures as follows: 67.9 +/- 4.4% for isolated CABG, 64.6 +/- 8.9% for valve surgery, 60.3 +/- 7.3% for combined coronary and valve surgery, and 63 +/- 10.7% for other procedures (p = 0.23). Ninety-seven percent of survivors lived at home. Risk factors for hospital death were emergency status, preoperative renal dysfunction, and postoperative complications such as myocardial infarction, cardiac failure requiring intraaortic balloon pumping, acute renal failure requiring replacement therapy, stroke, and ventilator dependency exceeding 48 hours. Among hospital survivors, risk factors for late death were carotid artery disease, chronic lung disease, renal dysfunction, and the occurrence of postoperative complications. CONCLUSIONS Long-term survival of octogenarians submitted to a wide variety of cardiac operations was satisfactory despite substantial rates of early complications and deaths. Most survivors were free from cardiac symptoms. Postoperative complications were stronger risk factors for hospital deaths than preoperative comorbidities and procedural variables. Their impact on long-term survival was also significant.

Increased expression and secretion of resistin in epicardial adipose tissue of patients with acute coronary syndrome

The purpose of this study was to test the hypothesis that specific epicardial adipose tissue (EAT) proinflammatory adipokines might be implicated in acute coronary syndrome (ACS). We compared expression and protein secretion of several EAT adipokines of male ACS with those of matched stable coronary artery disease (CAD) patients and controls with angiographically normal coronary arteries. The effect of supernatant of cultured EAT on endothelial cell permeability in vitro was also evaluated in the three study groups. EAT of ACS patients showed significantly higher gene expression and protein secretion of resistin than patients with stable CAD. Interleukin-6, plasminogen activator inhibitor-1, and monocyte chemoattractant protein-1 genes were also significantly overexpressed in ACS compared with the control group but not when compared with stable CAD. Immunofluorescence of EAT sections revealed a significantly greater number of CD68(+) cells in ACS patients than stable CAD and control groups. The permeability of endothelial cells in vitro was significantly increased after exposure to supernatant of cultured EAT from ACS, but not control or stable CAD groups, and this effect was normalized by anti-resistin antiserum. We found that EAT of patients with ACS is characterized by increased expression and secretion of resistin and associated with increased in vitro endothelial cell permeability.

Left atrial remodelling early after mitral valve repair for degenerative mitral regurgitation

Objective: Left atrial (LA) size is an important predictor of outcome after mitral valve replacement in patients with symptomatic chronic mitral regurgitation (MR). Data on LA remodelling after mitral valve repair (MVr) for chronic non-ischaemic MR are scarce. The aim of this study was to assess changes in LA size early after MVr for chronic severe degenerative MR and to identify clinical and echocardiographic correlates of those changes. Methods: The study analysed 225 consecutive patients who underwent MVr and were echocardiographically evaluated in our hospital within 1 month before and 1–6 months after surgery. Patients with MR aetiology other than degenerative, associated aortic valve replacement, or congenital heart disease were excluded. The remaining 79 patients (aged 60 (SD 12) years, 55 men) with isolated chronic severe degenerative MR formed the study group. LA reverse remodelling was defined as a decrease in LA volume index (LAVi) ⩾15%. Results: LA dimensions significantly decreased after MVr (p<0.001). Mean LAVi reduction was 29% (SD 18%). LA reverse remodelling was observed in 63 patients (80%). Correlates of LAVi reduction were preoperative LAVi (p = 0.008), systolic and diastolic blood pressure (p = 0.032, p = 0.009), postoperative transmitral mean pressure gradient (p = 0.001) and residual MR (p = 0.043). LAVi reduction was lower in patients >45 years (p = 0.008) and in hypertensive patients (p = 0.031). Conclusion: LA reverse remodelling is common early after MVr for chronic severe degenerative MR. Preoperative LAVi, blood pressure, postoperative transmitral mean pressure gradient, residual MR and age >45 are related to LAVi reduction. The prognostic value of LA reduction in this setting needs further study.

Mild inflammatory activation of mammary arteries in patients with acute coronary syndromes

Acute coronary syndromes (ACS) are characterized by multiple unstable coronary plaques and elevated circulating levels of inflammatory biomarkers. The endothelium of internal mammary arteries (IMA), which are atherosclerosis resistant, is exposed to proinflammatory stimuli as vessels that develop atherosclerosis. Our study investigated the IMA endothelial expression of inflammatory molecules in patients with ACS or chronic stable angina (CSA). IMA demonstrated normal morphology, intact endothelial lining, and strong immunoreactivity for glucose transporter 1. E-selectin expression was observed more frequently in IMA of ACS patiention than CSA patients (ACS 61% vs. CSA 14%, P = 0.01). High fluorescence for major histocompatibility complex (MHC) was significantly more frequent on the luminal endothelium (ACS 66.7% vs. CSA 17.6%, P = 0.001 for class I; and ACS 66.7% vs. CSA 6.2%, P = 0.0003 for class II-DR) and on the vasa vasorum (ACS 92.9% vs. CSA 33.3% and 7.7%, P = 0.0007 and P < 0.0001 for class I and class II-DR, respectively) of ACS patients than CSA patients. ICAM-1, VCAM-1, Toll-like receptor 4, tissue factor, IL-6, inducible nitric oxide synthase, and TNF-alpha expression were not significantly different in ACS and CSA. Circulating C-reactive protein [ACS 4.8 (2.6-7.3) mg/l vs. CSA 1.8 (0.6-3.5) mg/l, P = 0.01] and IL-6 [ACS 4.0 (2.6-5.5) pg/ml vs. CSA 1.7 (1.4-4.0) pg/ml, P = 0.02] were higher in ACS than CSA, without a correlation with IMA inflammation. The higher E-selectin, MHC class I and MHC class II-DR on the endothelium and vasa vasorum of IMA from ACS patients suggests a mild, endothelial inflammatory activation in ACS, which can be unrelated to the presence of atherosclerotic coronary lesions. These findings indicated IMA as active vessels in coronary syndromes.

Modified pump-driven venous bypass in surgery for renal cell carcinoma (RCC) involving the inferior vena cava (IVC)

Abstract. Surgical management of renal cell carcinoma (RCC) with a tumour thrombus that infiltrates the caval wall or extends above the hepatic veins can be problematic. Total control of the suprahepatic inferior vena cava (IVC) is mandatory in order to prevent thrombus mobilization and minimize blood loss. Pump-driven veno-venous bypass (VVB), modified by adding portal decompression, is a safe and useful procedure and avoids the important risks connected with deep hypothermic circulatory arrest while allowing the normal perfusion of vital organs.

Intrahepatic tumor thrombectomy through an abdominal diaphragmatic approach

Radical excision of renal cancer with propagation into the intrahepatic and intrapericardial inferior vena cava is an accepted surgical procedure.1.2 In a case of renal cancer with inferior vena caval suprahepatic involvement we verified the possibility of approaching the intrapericardial inferior vena cava through a limited diaphragmatic incision. CASE REPORT In a 75-year-old woman ultrasound and computerized tomography revealed a large solid mass in the left kidney and a vena caval thrombus extending above the suprahepatic veins. Magnetic resonance imaging and venacavography confirmed the diagnosis. The tumor was exposed through a Accepted for publication May 23, 1997. transverse abdominal approach combined with an epigastric vertical incision. The affected kidney was completely freed by ligation and section of the artery, ureter and vascular attachments. It remained attached only to the inferior vena cava and was transposed medially to the left mesocolon. The infrahepatic inferior vena cava was widely exposed by dividing the venous branches to the caudate and left lobes of the liver, and ligating the lumbar vessels. The diaphragm was exposed and incised in the midline at the level of its anterior insertion to the central tendon (fig. 1). The pericardial cavity was immediately entered. The upper extremity of the thrombus, placed at the diaphragm level, was evaluated by intraoperative ultrasound and its extension was confirmed by careful palpation under direct vision. A finger was then passed around the intrapericardial inferior vena cava above the thrombus and an umbilical tape was positioned. Other tapes were positioned around the hepatic hilum, infrarenal inferior vena cava, right renal vein and artery contralateral to the tumor. All tapes were clamped

Aortic root replacement with a valved conduit containing a stented xenograft

The Bentall operation is a well-established procedure for aortic root replacement, generally contemplating the use of a mechanical valve substitute. We have devised a simple modification by which a stented bioprosthesis is sutured inside, rather than at the extremity, of a vascular tube graft. This facilitates the technique of implantation and may simplify a redo procedure in case of valve failure.

Off-pump coronary artery surgery with the Coronéo Cor-Vasc stabilizing device: clinical experience of 141 patients.

Objectives Numerous devices have been successfully introduced in off-pump coronary artery bypass graft (OPCABG) surgery, most of them being disposable tools based on suction stabilization. Coronéo Cor-Vasc is a reusable system combining suction positioning with compression stabilization. The purpose of this study was to analyze our experience in OPCABG with the Cor-Vasc system. Methods Between March 2001 and May 2008, 141 patients (age = 71.1 ± 7.5 years) underwent OPCABG surgery using the Cor-Vasc system, representing 6.3% of the case volume of isolated coronary artery bypass graft surgery in the same period. Eighty-eight patients (62.4%) underwent surgery on an urgent basis. In 95 patients (67.4%), the OPCABG option was selected after finding a diseased ascending aorta at intraoperative epiaortic ultrasound. Results Among 334 anastomoses (mean = 2.4 ± 1 per patient), 242 (95 patients) were fashioned with bilateral and 54 (46 patients) with single internal thoracic artery, respectively. In 89.4 and 73% of patients, a complete and a total arterial myocardial revascularization was achieved, respectively. There were two strokes (1.4%) and two myocardial infarctions (1.4%). Two patients died in the hospital (1.4%). Median ICU and in-hospital length of stay were 31.2 h and 10 days, respectively. Conclusion In our experience, the use of the Cor-Vasc system, including the device-learning curve, was associated with low mortality and morbidity indexes in an aged population with a high risk of stroke. The system appeared to be sufficiently versatile and potentially cost-effective when compared with disposable devices.