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Dive into the research topics where Bassam Hallis is active.

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Featured researches published by Bassam Hallis.


FEBS Letters | 2001

Tyrosine-1290 of tetanus neurotoxin plays a key role in its binding to gangliosides and functional binding to neurones

Oliver Chow-Worn; Lindsey Spaven; Nigel Silman; Bassam Hallis; Clifford C. Shone

Tetanus toxin acts by blocking the release of glycine from inhibitory neurones within the spinal cord. An initial stage in the toxins action is binding to acceptors on the nerve surface and polysialogangliosides are a component of these acceptor moieties. Using site‐directed mutagenesis, we identify tyrosine‐1290 of tetanus toxin as a key residue that is involved in ganglioside binding. This residue, which is located at the centre of a shallow pocket on the β‐trefoil domain of the tetanus Hc fragment, is also shown to play a key role in the functional binding of tetanus toxin to spinal cord neurones leading to the inhibition of neurotransmitter release.


Archive | 1993

Characterization of Monoclonal Antibodies to Botulinum Type A Neurotoxin

Bassam Hallis; Sarah J. Fooks; Clifford C. Shone; Peter Hambleton

The botulinum neurotoxin types primarily involved in human illness are types A, B, E and F. Type A neurotoxin is the most intensively studied of the neurotoxins. However the antigenic sites remain unknown. The aim of the current project is to study the structure and determine the location of the antigenic sites of the type A neurotoxin.


FEBS Journal | 1993

Proteolytic cleavage of synthetic fragments of vesicle-associated membrane protein, isoform-2 by botulinum type B neurotoxin

Clifford C. Shone; Conrad P. Quinn; Robin Wait; Bassam Hallis; Sarah G. Fooks; Peter Hambleton


Applied and Environmental Microbiology | 1999

Development of an In Vitro Bioassay for Clostridium botulinum Type B Neurotoxin in Foods That Is More Sensitive than the Mouse Bioassay

Matthew Wictome; Kirsti Newton; Karen Jameson; Bassam Hallis; Paul Dunnigan; Eric Mackay; Sally Clarke; Richard Taylor; Joy Gaze; Keith Foster; Clifford C. Shone


Archive | 2005

Delivery of superoxide dismutase to neuronal cells

Clifford C. Shone; John Mark Sutton; Bassam Hallis; Nigel Silman


Archive | 1998

Antibody for a toxin assay, and method of obtaining same

Clifford C. Shone; Bassam Hallis; Benjamin Arthur Frederick James; Conrad P. Quinn


Archive | 1995

ASSAY OF TETANUS- AND BOTULINUM TOXINS

Bassam Hallis; Benjamin Arthur Frederick James; Conrad P. Quinn; Clifford C. Shone


Archive | 1995

Dosage de toxines

Clifford C. Shone; Bassam Hallis; Benjamin Arthur Frederick James; Conrad P. Quinn


Archive | 1995

Bestimmung der tetanus- und botulinum toxine

Clifford C. Shone; Bassam Hallis; Benjamin Arthur Frederic James; Conrad P. Quinn


Archive | 1995

Dosage de toxines du tetanos et du botulisme

Bassam Hallis; Benjamin Arthur Frederick James; Conrad P. Quinn; Clifford C. Shone

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Conrad P. Quinn

Centers for Disease Control and Prevention

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