Bassam Hallis
Salisbury University
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Publication
Featured researches published by Bassam Hallis.
FEBS Letters | 2001
Oliver Chow-Worn; Lindsey Spaven; Nigel Silman; Bassam Hallis; Clifford C. Shone
Tetanus toxin acts by blocking the release of glycine from inhibitory neurones within the spinal cord. An initial stage in the toxins action is binding to acceptors on the nerve surface and polysialogangliosides are a component of these acceptor moieties. Using site‐directed mutagenesis, we identify tyrosine‐1290 of tetanus toxin as a key residue that is involved in ganglioside binding. This residue, which is located at the centre of a shallow pocket on the β‐trefoil domain of the tetanus Hc fragment, is also shown to play a key role in the functional binding of tetanus toxin to spinal cord neurones leading to the inhibition of neurotransmitter release.
Archive | 1993
Bassam Hallis; Sarah J. Fooks; Clifford C. Shone; Peter Hambleton
The botulinum neurotoxin types primarily involved in human illness are types A, B, E and F. Type A neurotoxin is the most intensively studied of the neurotoxins. However the antigenic sites remain unknown. The aim of the current project is to study the structure and determine the location of the antigenic sites of the type A neurotoxin.
FEBS Journal | 1993
Clifford C. Shone; Conrad P. Quinn; Robin Wait; Bassam Hallis; Sarah G. Fooks; Peter Hambleton
Applied and Environmental Microbiology | 1999
Matthew Wictome; Kirsti Newton; Karen Jameson; Bassam Hallis; Paul Dunnigan; Eric Mackay; Sally Clarke; Richard Taylor; Joy Gaze; Keith Foster; Clifford C. Shone
Archive | 2005
Clifford C. Shone; John Mark Sutton; Bassam Hallis; Nigel Silman
Archive | 1998
Clifford C. Shone; Bassam Hallis; Benjamin Arthur Frederick James; Conrad P. Quinn
Archive | 1995
Bassam Hallis; Benjamin Arthur Frederick James; Conrad P. Quinn; Clifford C. Shone
Archive | 1995
Clifford C. Shone; Bassam Hallis; Benjamin Arthur Frederick James; Conrad P. Quinn
Archive | 1995
Clifford C. Shone; Bassam Hallis; Benjamin Arthur Frederic James; Conrad P. Quinn
Archive | 1995
Bassam Hallis; Benjamin Arthur Frederick James; Conrad P. Quinn; Clifford C. Shone