Beata Chrapko

Role of 18F-FDG PET/CT in the diagnosis of inflammatory and infectious vascular disease

This review article discusses the utility of 18F-FDG PET/CT in diagnosis and management of vascular disease. We stress usefulness of this method in large vessel inflammation and infection. In our work we based on the literature analysis and clinical cases diagnosed in our institution by use of 18F-FDG PET/CT. The literature exploration was focusing on vascular inflammation and infections and 18-FDG PET. The search was performed on PubMed database and cross referencing. We present the practical review with several images of vascular diseases like: Takayasu arteritis, giant cell arteritis, vascular graft infections, abdominal aortic aneurysm infections and cases of aortitis and periaortitis. From this work inflammation associated with atheromatic process and vulnerable atherosclerotic plaque we excluded. 18F-FGD PET/CT is a sensitive metabolic, reliable, non-invasive imaging modality suitable for diagnosis and follow-up of inflammation and infections in vascular system.

Takotsubo syndrome in a patient after renal transplantation

Summary Background Takotsubo syndrome (TTS) is a transient cardiomyopathy of unknown origin, clinically manifesting as acute coronary syndrome (ACS). This syndrome mainly occurs in postmenopausal women and has a temporary relationship with emotional or physical stress. Case Report TTS occurred in 46-year-old female patient on the first day after renal transplantation. The predominant symptoms were connected with ACS, performed with low grade troponin elevation and characteristic shape of left ventricle depicted in echocardiography. Taking into consideration the risk of the development of contrast-induced nephropathy, coronary angiography (CA) was delayed; myocardial perfusion scintigraphy and iodine-123 metaiodobenzylguanidine (123I-mIBG) myocardial uptake were performed to confirm the clinical suspicion. Myocardial perfusion scintigraphy (MPS) performed in rest condition showed normal perfusion but myocardial uptake of 123I-mIBG was impaired. Within 6 months after surgery, full recovery of all biochemical and functional parameters of the left ventricle were observed. At that time CA was done, depicting normal coronary arteries. Conclusions TTS could be diagnosed by the use of non-nephrotoxic tests – 123I-mIBG myocardial scintigraphy, MPS and echocardiography.

Quantitative evaluation of crossed cerebellar diaschisis, using voxel-based analysis of Tc-99m ECD brain SPECT

BACKGROUND In the recent literature there is no consensus regarding the relationships between crossed cerebellar diaschisis (CCD) with the primary lesion size, severity or location. Thus, the aim of the present study was to investigate relationship between the size and severity of cerebral lesions and CCD in patients with chronic stroke, using voxel-based analysis of Tc-99m ECD single-photon emission computed tomography (SPECT). MATERIAL AND METHODS We retrospectively reviewed data of 57 patients with chronic ischemic lesions localized unilaterally in the cerebral hemisphere. SPECT evaluation was performed with the voxel-based analysis. The percentage inter-hemispheric asymmetry index (AI) and the volume of abnormal clusters of voxels (CV) were ascertained for hypoperfusion in the supratentorial lesion and contralateral cerebellum. RESULTS CCD was present in 35.1% cases. In Group CCD (+), the CV and AI of supratentorial hypoperfusion (median 128.1 ml and 21.9%, respectively) were significantly higher compared with Group CCD(-) (median 41.4 ml and 18.0%, respectively). Statistically significant correlation was found between CV of supratentorial and cerebellar perfusion defects (r = 0.4; p < 0.05), between AI of supratentorial and cerebellar perfusion defects (r = 0.6; p < 0.05) and between CV of supratentorial defect and AI of cerebellar perfusion defects (r = 0.6; p < 0.05). CONCLUSIONS Our data suggest, that in the chronic stage of stroke, the size and severity of the supratentorial lesion are determinants of CCD, correlating with the degree of cerebellar hypoperfusion.

Iodine-123 metaiodobenzylguanidine myocardial imaging in haemodialysed patients asymptomatic for coronary artery disease: a preliminary report.

AimThe aim of this study was to evaluate the usefulness of iodine-123 metaiodobenzylguanidine (123I-mIBG) myocardial scintigraphy in the detection of cardiac sympathetic neuropathy in haemodialysed patients without relevant cardiovascular symptoms. Materials and methodsA group of 20 haemodialysed patients were examined. The stress/rest myocardial perfusion scintigraphy by gated single-photon emission computed tomography was performed. Cardiac sympathetic functions were evaluated by single-photon emission computed tomography and planar 123I-mIBG myocardial scintigraphy and also by 24-h Holter study, with heart rate variability (HRV) and signal-averaged electrocardiogram analysis of ventricular late potentials. Semiquantitative analysis of 123I-mIBG myocardial uptake was expressed as routine heart/mediastinum ratio (HMR) 15 [early (eHMR)] and 240 min [delayed (dHMR)] after administration and washout rate (WOR). ResultsMyocardial perfusion scintigraphy showed normal values of all parameters, but semiquantitative 123I-mIBG cardiac imaging assessment indicated low values of HMR (eHMR 1.87±0.27; dHMR 1.74±0.25) and high values of WOR (31.38±9.49) compared with normal values. In 10 patients (50%) ventricular late potential was determined, and in these patients mean values of dHMR came up to 1.59±0.20. The mean value of HRV came up to 88.40±16.05 and significant correlations were found between HRV and eHMR (P=0.01) and dHMR (P=0.007). Conclusion 123I-mIBG scintigraphy can detect very early stages of cardiac sympathetic dysfunction. Low values of HMR and high values of WOR suggest an impaired cardiac adrenergic system in patients without any relevant symptoms of heart failure. Low values of HRV may confirm cardiac autonomic neuropathy.

Multiple and solitary skeletal muscle metastases on 18F-FDG PET/CT imaging.

ObjectiveThe aim of this study was to investigate the features and patterns of skeletal muscle metastases (SMM) detected with 18F-fluorodeoxyglucose (18F-FDG) PET/computed tomography (PET/CT). Participants and methodsOur database was analyzed for patients with pathologically proven malignancy, who underwent 18F-FDG PET/CT in our institution. The patients with SMM were included in the study group on the basis of the final diagnosis confirmed by follow-up or histopathology. Images were acquired using a PET/CT system Biograph mCT S(64)-4R. CT was performed without contrast enhancement. ResultsThe selected group included 31 patients (1.7% of the database, which consisted of 1805 patients). A total of 233 lesions were found. The prevalence of SMM evaluated in specific primary malignancies was the highest in melanoma (6.9%), followed by carcinoma of unknown primary (4.4%), colorectal cancer (4.1%) and lung cancer (2.8%). Three patterns of skeletal muscle metastatic involvement were observed: multiple SMM accompanied by other metastases (64.5%), solitary lesion associated with other metastases (29%) and isolated intramuscular lesions (two cases, 6.5%). Isolated SMM represented recurrence of the malignant disease. In patients with extraskeletal metastases, solitary or multiple SMM did not affect tumor staging. ConclusionSolitary SMM are less common than multiple on 18F-FDG PET/CT imaging. SMM are usually associated with other metastases and do not affect tumor staging. The cases of isolated SMM are very rare. Nevertheless, in patients with a diagnosis of malignant disease, a solitary, 18F-FDG avid intramuscular focus should be suspected to represent metastasis.

Efficacy of radiosynoviorthesis and its impact on chosen inflammatory markers

Radiosynoviorthesis is used for the local treatment of recurrent joint effusions and leads to synovium necrosis after radionuclide administration. This procedure provides opportunity to full recovery of normal synovium function after local corticosteroids and systemic modifying drugs failure.

Relationship of haemodialysis therapy duration and cardiac adrenergic system function assessed by iodine-123 metaiodobenzylguanidine imaging in haemodialysed nondiabetic patients.

ObjectiveThe aim of the study was to evaluate the relationship of haemodialysis therapy duration with the function of the cardiac adrenergic system in nondiabetic patients. MethodsThirty haemodialysed male patients were enrolled in this study; all patients were evaluated by myocardial perfusion imaging at rest and after dynamic stress, with the assessment of left ventricular ejection fraction (LVEF) at rest and after stress and summed stress score (SSS). Single photon emission computed tomography and planar iodine-123 metaiodobenzylguanidine myocardial scintigraphy were also performed in all the patients. Semiquantitative analysis of iodine-123 metaiodobenzylguanidine myocardial uptake was expressed as the routine heart-to-mediastinum ratio (HMR): 15 min [early HMR (eHMR)] and 4 h [delayed HMR (dHMR)] post administration as well as the washout rate. Twenty-four hours of Holter studies were carried out and heart rate variability was evaluated. ResultsSignificant correlations (Spearman’s tests) were found between the duration of haemodialysis treatment and the following ratios: eHMR (P=0.03; r=−0.378), dHMR (P=0.04; r=−0.367) and washout rate (P=0.05; r=0.352). Further significant correlations were found between eHMR and LVEFs (P=0.03; r=0.379), SSS (P=0.01; r=−0.429) and between dHMR and LVEFs (P=0.005; r=0.496), LVEFr (P=0.03; r=0.379) and SSS (P=0.02; r=−0.404). ConclusionThe duration of haemodialysed patients appears to be an important factor influencing the cardiac sympathetic nervous system.

Evaluation of somatostatin receptors in large cell pulmonary neuroendocrine carcinoma with 99mTc-EDDA/HYNIC-TOC scintigraphy.

ObjectiveLarge cell pulmonary neuroendocrine carcinoma (LCNEC) is a poorly differentiated and high-grade neoplasm. It is positioned between an atypical carcinoid and small cell neuroendocrine carcinoma of the lung in a distinct family of pulmonary neuroendocrine tumors. The aim of our study was to detect somatostatin receptors in this uncommon malignancy and to evaluate the sensitivity of somatostatin receptor scintigraphy (SRS) in LCNEC staging. MethodsWe analyzed data of 26 patients (mean age: 61.5±7.9 years) with histologically confirmed diagnosis of LCNEC, including 18 cases not treated surgically and eight patients after the resection of the primary tumor. SRS was carried out with technetium-99m ethylene diamine-diacetic acid/hydrazinonicotinyl-Tyr3-octreotide (99mTc-TOC). A visual analysis of scintigraphic images was done with reference to conventional imaging modalities (computed tomography and bone sicintigraphy). ResultsSRS sensitivity for the detection of primary lesions, supradiaphragmatic metastases, and infradiaphragmatic metastases was 100, 83.3%, and 0%, respectively. Five out of 13 metastases to the liver appeared on SRS as photopenic foci, visible on the background of physiological hepatic activity. Only one of the nine metastases to the skeletal system was found by SRS with sensitivity as low as 11.1%. The overall SRS sensitivity for the detection of secondary lesions and of all lesions was 54.8 and 62.2%, respectively. ConclusionWithin a rather large series of LCNEC, the primary tumor showed an uptake of 99mTc-TOC in all cases, whereas some metastases did show 99mTc-TOC uptake and some others did not.

Usefulness of 99mTc-ECD brain SPECT with voxel-based analysis in evaluation of perfusion changes early after carotid endarterectomy

Summary Background Association between preoperative perfusion pattern and reperfusion after carotid endarterectomy (CEA) is an important yet unexplored topic. Therefore, the aim of our study was to determine whether 99mTc-ECD single-photon emission computed tomography (SPECT) performed before carotid endarterectomy in patients with internal carotid artery (ICA) stenosis may be helpful in predicting early perfusion changes after revascularization. Material/Methods The examined group consisted of 30 patients (mean age 67.4±9.6 years) with ICA stenosis who underwent CEA. Infarction was demonstrated on computed tomography (CT) in 12 cases. Brain perfusion SPECT was performed 1–3 days before CEA and 3–5 days after the surgery. Voxel-based analysis was carried out with Brain SPECT Quantification software. For evaluation of preoperative interhemispheric asymmetry of perfusion, the percentage asymmetry index (AI) was calculated. For comparison of perfusion before and after CEA, the percentage relative difference (RD) was computed. Results Before CEA, cerebral hypoperfusion was seen in 26 cases, including 15 participants with normal CT. After CEA, the following changes of perfusion were observed: perfusion increase n=18 (ipsilateral and bilateral), deterioration n=1, mixed patterns n=2, no change n=9. In patients with preoperative ipsilateral hypoperfusion and perfusion increase after CEA, AI correlated significantly with RD (r=0.48, p=0.04). Conclusions Our results suggest that perfusion increase 3–5 days after CEA is higher in patients with greater ipsilateral asymmetry index. Evaluation of preoperative AI may help to identify patients in whom rapid reperfusion is more likely.

Complex Regional Pain Syndrome type I with atypical scintigraphic pattern — diagnosis and evaluation of the entity with three phase bone scintigraphy. A case report

Complex Regional Pain Syndrome (CRPS) is a neurological disorder of unknown etiology which may lead to severe disability. Its diagnosis is very difficult and based on diagnostic criteria which have been changing over last years. Still, there is no golden standard in diagnosis of this entity. Three-phase bone scan is a widely used diagnostic modality which has been proved useful in CRPS evaluation. The syndrome may present various scintigraphic patterns. Different diagnostic modalities can also be helpful when CRPS is suspected including plain film radiography, magnetic resonance imaging and ultrasonography. Multidisciplinary approach is necessary for proper and quick diagnosis. We present a case of CRPS in 12-year-old girl in whom the diagnosis was based on the bone scan.