Beáta Hemmelová
Masaryk University
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Featured researches published by Beáta Hemmelová.
Carcinogenesis | 2014
Miroslav Svoboda; Jana Slyskova; Michaela Schneiderova; Peter Makovicky; Ludovit Bielik; Miroslav Levy; Ludmila Lipska; Beáta Hemmelová; Zdenek Kala; Markéta Protivánková; Ondrej Vycital; Vaclav Liska; Lucie Schwarzová; Ludmila Vodickova; Pavel Vodicka
Colorectal cancer (CRC) is one of the main causes of death of neoplasia. Demand for predictive and prognostic markers to reverse this trend is increasing. Long non-coding RNA HOTAIR (Homeobox Transcript Antisense Intergenic RNA) overexpression in tumors was previously associated with poor prognosis and higher mortality in different carcinomas. We analyzed HOTAIR expression levels in tumor and blood of incident sporadic CRC patients in relation to their overall survival with the aim to evaluate surrogate prognostic marker for CRC. Tissue donor group consisted of 73 CRC patients sampled for tumor and normal tissue. Blood donor group was represented by 84 CRC patients compared with 40 healthy controls. Patients were characterized for tumor-node-metastasis stage, tumor grade, microsatellite instability and tumor penetration by stromal cells. HOTAIR levels were assessed by real-time quantitative PCR. CRC patients had higher HOTAIR expression in blood than healthy controls (P = 0.0001), whereas there was no difference in HOTAIR levels between tumor and adjacent mucosa of CRC patients. HOTAIR levels positively correlated between blood and tumor (R = 0.43, P = 0.03). High HOTAIR levels in tumors were associated with higher mortality of patients [Coxs proportional hazard, hazard ratio = 4.4, 95% confidence interval: 1.0-19.2, P = 0.046]. The hazard ratio was even higher when blood HOTAIR levels were taken into account (hazard ratio = 5.9, 95% confidence interval: 1.3-26.1, P = 0.019). Upregulated HOTAIR relative expression in primary tumors and in blood of CRC patients is associated with unfavorable prognosis. Our data suggest that HOTAIR blood levels may serve as potential surrogate prognostic marker in sporadic CRC.
International Journal of Colorectal Disease | 2016
Lumir Kunovsky; Beáta Hemmelová; Zdenek Kala; Jiri Dolina; Stefan Konecny; Igor Penka
We present a 29-year-old patient with Crohn disease diagnosed in 2009 who underwent right side hemicolectomy in January 2014 (because of a stenosis of caecum and ascending colon). Side to side anastomosis was performed. The control colonoscopy did not show signs of CD recurrence, there were only three aphthous lesions near the base of the colon. Rutgeerts score was i1, so the step-up therapy was not indicated. After the procedure, the patient remained in remission on a conservative treatment using azathioprine. The patient is a non-smoker since 2010, before that she used to smoke five cigarettes per day and before conception she used per oral contraception for 8 years until August 2014. Because of the remission of CD and after a consensus with a gastroenterologist, the first pregnancy was planned. During the pregnancy, the medication remained on azathioprine.
Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti | 2010
Štěpán Tuček; Jiří Tomášek; Jana Halámková; Igor Kiss; Tomáš Andrašina; Beáta Hemmelová; Dagmar Adámková Krákorová; Rostislav Vyzula
Acta Chirurgica Iugoslavica | 2014
Tomáš Grolich; Tomáš Skřička; Oldřich Robek; Zdeněk Kala; Beáta Hemmelová; Radoslav Hrivnák
The Indian journals of medical research | 2010
Zdeněk Kala; Pavel Weber; Beáta Hemmelová; Filip Marek; Jan Hlavsa
Vnitřní lékařství | 2017
Lumír Kunovský; Milan Dastych; Radek Kroupa; Beáta Hemmelová; Katarína Múčková; Miroslava Chovancová; Lenka Kučerová; Jiří Dolina
Indian Journal of Medical Research | 2010
Zdeněk Kala; Pavel Weber; Beáta Hemmelová; Filip Marek; Jan Hlavsa; Martin Sobotka
Archive | 2018
Beáta Hemmelová; Igor Penka; Martin Man; Oldřich Robek; Zdeněk Kala
Archive | 2018
Beáta Hemmelová; Šárka Bohatá; Jitka Kyclová; Zdeněk Kala; Igor Penka
Cancer Research | 2018
Tana Machackova; Dominika Brchnelova; Zdenek Kala; Vladimír Procházka; Tomáš Grolich; Lukas Fiala; Beáta Hemmelová; Jaroslav Juracek; Marek Vecera; Jiri Sana; Natalia Gablo; Parwez Ahmad; Marek Svoboda; Ondrej Slaby