Beata Matuszek

Increased serum insulin-like growth factor-1 levels in women with gestational diabetes.

BACKGROUNDnInsulin-like growth factor-1 (IGF-1), which has effects similar to insulin, reduces blood glucose level, improves insulin sensitivity and may play an important role in the pathogenesis of gestational diabetes (GDM).nnnOBJECTIVEnThe aim of the study was to estimate the concentration of IGF-1 in pregnant women with GDM and 3 months after delivery and find relationships between IGF-1 and clinical and biochemical parameters.nnnMATERIALS AND METHODSn67 women between 24th - 28th week of pregnancy were enrolled in the study (46 with GDM and 21 as a control group). All women underwent clinical and biochemical examinations. Concentrations of IGF-1, adiponectin, fasting glucose, insulin, lipids, CRP, fibrinogen were measured during pregnancy, additionally IGF-1 concentration was determined 3 months after delivery.nnnRESULTSnIGF-1, glucose, insulin, CRP, fibrinogen, lipids concentrations and HOMA-IR were significantly higher in women with GDM than in the control group (p<0.05). A significant decrease in IGF-1 concentration was observed in both groups after delivery. In the GDM group significant correlations between IGF-1 and BMI (r=0.370, p<0.05), insulin (r=0.469, p<0.01) and HOMA-IR (r=0.439, p<0.01) were observed. Regression analysis with IGF-1 as a dependent parameter showed that only BMI and insulin remained as predictors, explaining 32% of plasma IGF-1 variation. Re-evaluation after delivery revealed impaired glucose tolerance in 9% of the population studied.nnnCONCLUSIONSnIncreased IGF-1 concentrations in pregnancy complicated with GDM may partly reflect metabolic disturbances, especially insulin resistance and hyperinsulinemia, and may be one of possible compensatory reactions of the organism in response to these disturbances.

Comparative analysis of adiponectin isoform distribution in pregnant women with gestational diabetes mellitus and after delivery

To evaluate the distribution of circulating adiponectin isoforms in pregnant women with gestational diabetes mellitus (GDM) and compare isoform distribution changes 12 months after delivery.

Selected markers of bone turnover in type 2 diabetic patients

Dia be tes mel li tus type 2 (DM2) is widely rec og nized se ri ous health prob lem among de vel oped and de vel op ing coun tries and it ap pears to be re lated to the changes from tra di tional pat terns of life to wards West ern life style. It is rec og nized as civi li za tion dis ease, which oc cur in epi demic pro por tions in mod ern so cie ties. Two im por tant ele ments con trib ute sig nifi cantly to the patho gene sis of DM2; tis sue in su lin re sis tance and pan cre atic β cell dys func tion. It is be lieved that in many cases DM2 is di ag nosed too late; when chronic com pli ca tions are al ready pres ent [5,19]. Vast ma jor ity of lit era ture show that dia be tes and re lated meta bolic dis tur bances can lead to sig nifi cant changes in bone me tabo lism [1,3,4,20,14]. Re gard less the dif fer ences in bone min eral den sity in pa tients with DM2 ab nor mali ties in bone for ma tion can be seen. De creased qual ity of the bone as well as im paired mi croand mac roar chi tec ture to gether with sus cep ti bil ity to falls re sult ing from the pres ence of chronic com pli ca tions leads to a greater in ci dence of frac tures in DM2 pa tients [3,14,10,24]. The mechanisms of bone alterations in DM2 are complex and still poorly understood. It depends on the number of protective factors on bone health, such as hyperinsulinemia, obesity, estrogens as well as factors accelerating bone resorption (e.g. hyperglycemia) [7,21, 24]. Therefore evaluation of bone metabolism in patients with DM2 undertaken in this study seems to be fully justified. In the present study we focused on the following bone markers CTx (C-terminal cross-linked telopeptide of the alpha chain of type I collagen) and OCN (osteocalcin). CTx levels reflect type I collagen degradation and indirectly represents bone resorption by the osteoclasts and loss of bone mass. OCN however is known as a highly specific marker of bone turnover rate and the activity of the osteoblasts [1,9,20,24]. The aim of this study was to Selected markers of bone turnover in type 2 diabetic patients