Beatrice Renault
Albert Einstein College of Medicine
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Publication
Featured researches published by Beatrice Renault.
Nature | 1995
Kenneth S. Krauter; Kate Montgomery; Yoon Sj; Janine M. LeBlanc-Straceski; Beatrice Renault; Ivonne Marondel; Herdman; Cupelli L; Amy Banks; Lieman J
Breakthrough: The Quest to Isolate the Gene for Hereditary Breast Cancer.By Kevin Davies and Michael White. Mac-millan: 1995. Pp. 370. £16.99. To be published in the United States by Wiley.
Genes, Chromosomes and Cancer | 2000
Shashi Bala; Holt Oliver; Beatrice Renault; Kate Montgomery; Shipra Dutta; Pulivarthi H. Rao; Jane Houldsworth; Raju Kucherlapati; Xiaodong Wang; R. S. K. Chaganti; V. V. V. S. Murty
Cytogenetic and molecular analyses have shown that the chromosome band 12q22 is recurrently deleted in male germ cell tumors (GCTs), indicating the presence of a candidate tumor suppressor gene (TSG) in this region. To identify the TSG, we mapped the APAF1 gene, a proapoptotic mammalian homologue of ced‐4, to chromosomal band 12q22, that suggested that this might be the candidate deleted gene in GCTs. We further localized the gene between the polymorphic markers D12S1671 and D12S1082 at 12q22 to determine the role of APAF1 in the pathogenesis of GCT, and we characterized its normal genomic structure and analyzed its alterations in GCTs. The APAF1 gene comprises 27 exons, with the coding region spanning 26. The region containing APAF1 was found to be deleted in GCT by fluorescence in situ hybridization analysis, but without evidence of coding sequence alterations. RT‐PCR and Western blot analysis showed APAF1 gene expression at detectable levels in all GCT cell lines analyzed. An aberrant‐sized APAF1 protein was seen in one cell line. This and 2 other cell lines carrying APAF1 deletions also exhibited defects in dATP‐mediated caspase‐3 activation. Caspase‐3 activity was effectively restored by addition of recombinant caspase‐9 and APAF1 proteins, and to a lesser extent by caspase‐9 alone, but not by APAF1 alone. These data do not support a TSG role for APAF1, but defects in other components of the apoptotic pathway that may be related to 12q22 deletion cannot be ruled out. Genes Chromosomes Cancer 28:258–268, 2000.
Nature | 2001
Kate Montgomery; Eunice Lee; Ashley Miller; Stephanie Lau; Cecilia Shim; Jeremy Decker; Denise Chiu; Suzanne Emerling; Mandeep Sekhon; Rachel Kim; Jack Lenz; Jinghua Han; Ilya Ioshikhes; Beatrice Renault; Ivonne Marondel; Sung-Joo Yoon; Kyu-Young Song; V. V. V. S. Murty; Steven Scherer; Raluca Yonescu; Ilan R. Kirsch; Thomas Ried; John D. McPherson; Richard A. Gibbs; Raju Kucherlapati
Our sequence-tagged site-content map of chromosome 12 is now integrated with the whole-genome fingerprinting effort. It provides accurate and nearly complete bacterial clone coverage of chromosome 12. We propose that this integrated mapping protocol serves as a model for constructing physical maps for entire genomes.
Nature Genetics | 1997
Craig T. Basson; David R. Bachinsky; Robert C. Lin; Tatjana Levi; Jacob A. Elkins; Johanna Soults; David Grayzel; Elena Kroumpouzou; Thomas A. Traill; Janine M. LeBlanc-Straceski; Beatrice Renault; Raju Kucherlapati; J. G. Seidman; Christine E. Seidman
Genomics | 1996
Kathleen C. Barnes; John D. Neely; David L. Duffy; Linda R. Freidhoff; Daniel R. Breazeale; Carsten Schou; Raana P Naidu; Paul N. Levett; Beatrice Renault; Raju Kucherlapati; Sebastiano Iozzino; Eva Ehrlich; Terri H. Beaty; David G. Marsh
Cancer Research | 1998
Boris Pasche; Yan Luo; Pulivarthi H. Rao; Stephen D. Nimer; Ethan Dmitrovsky; Philip Caron; Lucio Luzzatto; Kenneth Offit; Carlos Cordon-Cardo; Beatrice Renault; Jaya M. Satagopan; Vundavalli V. Murty; Joan Massagué
Genomics | 1996
V.V.V.S. Murty; Beatrice Renault; Catherine T. Falk; George J. Bosl; Raju Kpati; R. S. K. Chaganti
Genome Research | 1999
Vundavalli V. Murty; Kate Montgomery; Shipra Dutta; Shashi Bala; Beatrice Renault; George J. Bosl; Raju Kucherlapati; R. S. K. Chaganti
Journal of the American Medical Informatics Association | 1995
Perry L. Miller; Prakash M. Nadkarni; Kenneth K. Kidd; Kei-Hoi Cheung; David C. Ward; Amy Banks; Patricia Bray-Ward; Lisa Cupelli; Valerie Herdman; Ivonne Marondel; Kate Montcomery; Beatrice Renault; Sunc-Joo Yoon; Kenneth S. Krauter; Raju Kucherlapati
Genomics | 1997
Beatrice Renault; Alain Hovnanian; Steven D. Bryce; Joan-Jung Chang; Stephanie Lau; Anavaj Sakuntabhai; Sarah Monk; Simon Carter; Colin J.D. Ross; Joanna Pang; Rebecca Twells; Susan Chamberlain; Anthony P. Monaco; Tom Strachan; Raju Kucherlapati