Beatriz Badilla

Beatriz Badilla; A.Y Arias; M Arias; Gerardo Mora; L.J Poveda

In the range of doses of 250-500 mg/kg (given i.p.) the aqueous extract of Loasa speciosa leaves showed an inhibitory effect on leukocyte migration, and a reduction on the pleural exudate, as well as dose-dependent anti-inflammatory and peripheral antinociceptive activities.

Pedro M. García-Barrantes; Beatriz Badilla

AIM OF THE STUDY Quassia amara L. is commonly used in Costarican folk medicine. It has been used for the treatment of a broad range of gastrointestinal symptoms such as dyspepsia, gastritis and constipation. In this study, the gastroprotective activity of two standardized extracts of Quassia amara L., Lipro(®) and Ligas(®), was evaluated. MATERIALS AND METHODS Anti-ulcerogenic properties were evaluated in female rats under acute ulcer-induction models (ethanol, indomethacin and hypotermic restraint). To get a deeper insight in the anti-ulcerogenic properties of the extracts, Ligas(®) was evaluated in the Shay rat model. Five parameters were estimated with this model: gastric mucus barrier, non-protein sulfhydril groups (NPSG) in the gastric mucosa, and pH, total acidity and peptic activity of the gastric juice. RESULTS Induction of ulcers by 95% ethanol (0.5 mL per os), indomethacin (100 mg/kgs.c.) and stress (2h in hypothermic restraint) was inhibited significantly with administration of Lipro(®) (p<0.05), in a dosage range from 4.9 mg/kg/d to 48.9 mg/kg/d. Treatment was given for one week. The extract Ligas(®) showed a significant augmentation of NPSG (p<0.05) in a dosage range from 4.0 to 39.7 mg/kg. Ligas(®) did not produce a significant change (p>0.05) in the other indicators. CONCLUSIONS Quassia amara L. standardized extracts, Lipro(®) and Ligas(®), showed an important anti-ulcerogenic effect in acute ulcer induction models. Their effect was related to an increase in gastric barrier mucus and non-protein sulfhydril groups.

Beatriz Badilla; Gerardo Mora; Luis Poveda

Fernando Chaves; Mauricio Chacón; Beatriz Badilla; Carolina Arévalo

Beatriz Badilla; Gerardo Mora; Antonio José Lapa; José Arthur Silva Ernim

Beatriz Badilla; Fernando Chaves; S Jiménez; G Rodríguez; Lj Poveda

Beatriz Badilla; Tatiana Miranda; Gerardo Mora; Kattia Vargas

Beatriz Badilla; J Cambronero; Jf Ciccio; T Cordero; G Mora

Beatriz Badilla; Fernando Chaves; Gerardo Mora; Luis Poveda

Beatriz Badilla; Fernando Chaves; F Cordoba; L Guadamuz; Gerardo Mora; Lj Poveda