Beatriz Guilhembernard Kosachenco

Local delivery of sirolimus nanoparticles for the treatment of in-stent restenosis

To test the local delivery of sirolimus nanoparticles following percutaneous transluminal coronary angioplasty (PTCA) to treat in‐stent restenosis (ISR) in a swine model.

Artrodese do joelho em cães pela fixação externa

Arthrodesis of the stifle joint was performed on seven healthy dogs. The fusion of right or left femorotibial joint was made using external skeletal fixation by placing a transfixation of Steinmann pins that were connected with autopolimerized acrylic bars. Intra-articular structures were removed and ostectomy of articular sur faces of distal femur and proximal tibia were made. After autogenous cancellous bone graft was inserted, immobilization was placed to maintain the selected joint angle measured in the preoperative period. The functional performance was observed and radiographic evaluation was done immediately after surgery, and at 30, 60 and 90 postoperative days. Fusion of the joint was judged by microscopic and macroscopic observations. The external skeletal fixation provided early return to weight-bearing function with satisfactory functional degree. Results of this study indicated that this type of immobilization is entirely satisfactory to produce arthrodesis of the stifle joint.