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Featured researches published by Ben Challacombe.


International Journal of Surgery | 2016

The SCARE Statement: Consensus-based surgical case report guidelines

Riaz A. Agha; Alexander J. Fowler; Alexandra Saeta; Ishani Barai; Shivanchan Rajmohan; Dennis P. Orgill; Raafat Yahia Afifi; Raha Al-Ahmadi; Joerg Albrecht; Abdulrahman Alsawadi; Jeffrey Aronson; M. Hammad Ather; Mohammad Bashashati; Somprakas Basu; Patrick J. Bradley; Mushtaq Chalkoo; Ben Challacombe; Trent Cross; Laura Derbyshire; Naheed Farooq; Jerome R. Hoffman; Huseyin Kadioglu; Veeru Kasivisvanathan; Boris Kirshtein; Roberto Klappenbach; Daniel M. Laskin; Diana Miguel; James Milburn; Seyed Reza Mousavi; Oliver J. Muensterer

INTRODUCTION Case reports have been a long held tradition within the surgical literature. Reporting guidelines can improve transparency and reporting quality. However, recent consensus-based guidelines for case reports (CARE) are not surgically focused. Our objective was to develop surgical case report guidelines. METHODS The CARE statement was used as the basis for a Delphi consensus. The Delphi questionnaire was administered via Google Forms and conducted using standard Delphi methodology. A multidisciplinary group of surgeons and others with expertise in the reporting of case reports were invited to participate. In round one, participants stated how each item of the CARE statement should be changed and what additional items were needed. Revised and additional items from round one were put forward into a further round, where participants voted on the extent of their agreement with each item, using a nine-point Likert scale, as proposed by the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) working group. RESULTS In round one, there was a 64% (38/59) response rate. Following adjustment of the guideline with the incorporation of recommended changes, round two commenced and there was an 83% (49/59) response rate. All but one of the items were approved by the participants, with Likert scores 7-9 awarded by >70% of respondents. The final guideline consists of a 14-item checklist. CONCLUSION We present the SCARE Guideline, consisting of a 14-item checklist that will improve the reporting quality of surgical case reports.


International Journal of Surgery | 2016

Preferred reporting of case series in surgery; the PROCESS guidelines

Riaz A. Agha; Alexander J. Fowler; Shivanchan Rajmohan; Ishani Barai; Dennis P. Orgill; Raafat Yahia Afifi; Raha Al-Ahmadi; Joerg Albrecht; Abdulrahman Alsawadi; Jeffrey Aronson; M. Hammad Ather; Mohammad Bashashati; Somprakas Basu; Patrick J. Bradley; Mushtaq Chalkoo; Ben Challacombe; Trent Cross; Laura Derbyshire; Naheed Farooq; Jerome R. Hoffman; Huseyin Kadioglu; Veeru Kasivisvanathan; Boris Kirshtein; Roberto Klappenbach; Daniel M. Laskin; Diana Miguel; James Milburn; Oliver J. Muensterer; James Ngu; Iain J. Nixon

INTRODUCTION Case series have been a long held tradition within the surgical literature and are still frequently published. Reporting guidelines can improve transparency and reporting quality. No guideline exists for reporting case series, and our recent systematic review highlights the fact that key data are being missed from such reports. Our objective was to develop reporting guidelines for surgical case series. METHODS A Delphi consensus exercise was conducted to determine items to include in the reporting guideline. Items included those identified from a previous systematic review on case series and those included in the SCARE Guidelines for case reports. The Delphi questionnaire was administered via Google Forms and conducted using standard Delphi methodology. Surgeons and others with expertise in the reporting of case series were invited to participate. In round one, participants voted to define case series and also what elements should be included in them. In round two, participants voted on what items to include in the PROCESS guideline using a nine-point Likert scale to assess agreement as proposed by the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) working group. RESULTS In round one, there was a 49% (29/59) response rate. Following adjustment of the guideline with incorporation of recommended changes, round two commenced and there was an 81% (48/59) response rate. All but one of the items were approved by the participants and Likert scores 7-9 were awarded by >70% of respondents. The final guideline consists of an eight item checklist. CONCLUSION We present the PROCESS Guideline, consisting of an eight item checklist that will improve the reporting quality of surgical case series. We encourage authors, reviewers, editors, journals, publishers and the wider surgical and scholarly community to adopt these.


European Urology | 2008

Robotic-assisted Laparoscopic Radical Cystectomy with Extracorporeal Urinary Diversion: Initial Experience

Declan Murphy; Ben Challacombe; Oussama Elhage; Tim O'Brien; Peter Rimington; Mohammad Shamim Khan; Prokar Dasgupta

BACKGROUND The use of robotic technology for laparoscopic prostatectomy is now well established. The same cannot yet be said of robotic-assisted laparoscopic radical cystectomy (RARC), which is performed in just a few centres worldwide. OBJECTIVE We present our technique and experience of this procedure using the da Vinci surgical system. DESIGN, SETTING, AND PARTICIPANTS From 2004 to 2007, 23 patients underwent RARC and urinary diversion at our institution. SURGICAL PROCEDURE We report the development of our technique for RARC, which involves posterior dissection, lateral pedicle control, anterior dissection, and lymphadenectomy prior to either ileal conduit urinary diversion or Studer pouch reconstruction performed extracorporeally. MEASUREMENTS Demographic and perioperative data were recorded prospectively. Oncologic and functional outcomes were assessed at 3- to 6-mo intervals. RESULTS AND LIMITATIONS To date, 23 patients have undergone this procedure at our institution. Of those, 19 had ileal loop urinary diversion and 4 were suitable for Studer pouch reconstruction. Mean total operative time plus or minus (+/-) standard deviation (SD) was 397+/-83.8min. Mean blood loss +/-SD was 278+/-229ml with one patient requiring a blood transfusion. Surgical margins were clear in all patients with a median +/-SD of 16+/-8.9 lymph nodes retrieved. The complication rate was 26%. At a mean follow-up +/-SD of 17+/-13 (range 4-40) mo, one patient had died of metastatic disease and one other is alive with metastases. The remaining 21 patients are alive without recurrence. CONCLUSIONS RARC remains a procedure in evolution in the small number of centres carrying out this type of surgery. Our initial experience confirms that it is feasible with acceptable morbidity and good short-term oncologic results.


BJUI | 2013

Current status of validation for robotic surgery simulators – a systematic review

Hamid Abboudi; Mohammed Shamim Khan; Omar M. Aboumarzouk; Khurshid A. Guru; Ben Challacombe; Prokar Dasgupta; Kamran Ahmed

Little is known on how best to train the future generation of robotic surgeons. It has been postulated that virtual reality (VR) simulators may aid the progression along the learning curve for this rapidly developing surgical technique within a safe training environment. There are several simulators available on the market, the best known is that developed by Intuitive Surgical Inc. The present study provides the first systematic review of all the trails of the various VR robotic platforms. It explores the evidence supporting the effectiveness of the various platforms for feasibility, reliability, validity, acceptability, educational impact and cost‐effectiveness. This article also highlights the deficiencies and future work required to advance robotic surgical training.


BJUI | 2010

A randomized trial of photoselective vaporization of the prostate using the 80-W potassium-titanyl-phosphate laser vs transurethral prostatectomy, with a 1-year follow-up

David M. Bouchier-Hayes; Scott Van Appledorn; Pat Bugeja; Helen Crowe; Ben Challacombe; Anthony J. Costello

Study Type – Therapy (RCT)
Level of Evidence 2b


European Urology | 2011

The Role of Laparoscopic and Robotic Cystectomy in the Management of Muscle-Invasive Bladder Cancer With Special Emphasis on Cancer Control and Complications

Ben Challacombe; Bernard H. Bochner; Prokar Dasgupta; Inderbir S. Gill; Khurshid A. Guru; Harry W. Herr; A. Mottrie; Raj S. Pruthi; Joan Palou Redorta; Peter Wiklund

CONTEXT Minimally invasive radical cystectomy (MIRC) techniques for the treatment of muscle-invasive bladder cancer (BCa) are being increasingly applied. MIRC offers the potential benefits of a minimally invasive approach in terms of reduced blood loss and analgesic requirements whilst striving to provide similar oncologic efficacy to open radical cystectomy (ORC). Whether quicker recovery, shorter hospital stay, and a reduction in complications are routinely achieved with MIRC remains to be proved in prospective comparisons. OBJECTIVE To explore both laparoscopic radical cystectomy (LRC) and robot-assisted radical cystectomy (RRC), focusing specifically on the oncologic parameters and comorbidity of the procedures. Reported complications from major centres are identified and categorised via the Clavien system. Positive margins rates, local recurrence, and both cancer-specific survival (CSS) and overall survival rates are assessed. EVIDENCE ACQUISITION A comprehensive electronic literature search was conducted in November 2010 using the Medline database to identify publications relating to laparoscopic, robotic, or minimally invasive radical cystectomy. EVIDENCE SYNTHESIS There are encouraging short- to medium-term results for both LRC and RRC in terms of postoperative morbidity and oncologic outcomes. It seems possible in experienced hands to perform a satisfactory minimally invasive lymphadenectomy regarding lymph node counts and levels of dissection. Positive soft-tissue margins are similar to large open series for T2/T3 disease but inferior for bulky T4 disease. Local recurrence rates and CSS rates seem equivalent to ORC at up to 3 yr of follow-up; however, mature outcome data still need to be presented before definitive comparisons can be made. CONCLUSIONS Robotic and laparoscopic cystectomy has a growing role in the management of muscle-invasive BCa. Long-term oncologic results are awaited, and there are concerns over the ability of MIRC to treat bulky and locally advanced disease, making careful patient selection vital. Forthcoming randomised trials in this area will more fully address these issues.


BJUI | 2005

Multimodal management of urolithiasis in renal transplantation.

Ben Challacombe; Prokar Dasgupta; R. C. Tiptaft; Jonathan Glass; Geoff Koffman; David Goldsmith; Mohammed Shamim Khan

To report the largest single series of renal transplant patients (adults and children) with urolithiasis, assess the risk factors associated with urolithiasis in renal transplant recipients, and report the outcome of the multimodal management by endourological and open procedures.


BJUI | 2012

Infection after transrectal ultrasonography-guided prostate biopsy: increased relative risks after recent international travel or antibiotic use: RISK FACTORS FOR INFECTION AFTER PROSTATE BIOPSY

Uday Patel; Prokar Dasgupta; Peter Amoroso; Ben Challacombe; James Pilcher; Roger Kirby

Study Type – Prognosis (case series)


International Journal of Clinical Practice | 2008

Robotic assisted radical cystectomy: short to medium-term oncologic and functional outcomes.

Prokar Dasgupta; Peter Rimington; Declan Murphy; Ben Challacombe; Ashok K. Hemal; Oussama Elhage; Mohammad Shamim Khan

Purpose:  To report short‐ and medium‐term oncological and functional outcomes of the first robotic‐assisted laparoscopic radical cystectomy (RARC) series from the UK.


Postgraduate Medical Journal | 2006

Robotic technology in urology.

Declan Murphy; Ben Challacombe; M S Khan; Prokar Dasgupta

Urology has increasingly become a technology-driven specialty. The advent of robotic surgical systems in the past 10 years has led to urologists becoming the world leaders in the use of such technology. In this paper, we review the history and current status of robotic technology in urology. From the earliest uses of robots for transurethral resection of the prostate, to robotic devices for manipulating laparoscopes and to the current crop of master–slave devices for robotic-assisted laparoscopic surgery, the evolution of robotics in the urology operating theatre is presented. Future possibilities, including the prospects for nanotechnology in urology, are awaited.

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Rick Popert

Guy's and St Thomas' NHS Foundation Trust

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Declan Murphy

Peter MacCallum Cancer Centre

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Declan Cahill

Guy's and St Thomas' NHS Foundation Trust

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Nicholas Raison

Guy's and St Thomas' NHS Foundation Trust

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Khurshid A. Guru

Roswell Park Cancer Institute

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