Bengt Herslöf
AstraZeneca
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Publication
Featured researches published by Bengt Herslöf.
Journal of Liposome Research | 1996
Magnus Blom; Lena Andersson; Anders Carlsson; Bengt Herslöf; Li Zhou; Åke Nilsson
AbstractA bilayer forming galactolipid, digalactosyldiacylglycerol (DGalDG) has been identified as a tool with suitable physicochemichal properties for pharmaceutical formulation work. One possible application is as a carrier for liposome entrapped drugs for intravenous administration. The fate of intravenously administered galactolipids is not known. In this study liposomal dispersions of galactolipids, containing [3H]fatty acid labelled DGalDG or monogalactosyldiacylglycerol (MGalDG) were injected intravenously in the rat and the disappearance from blood and uptake by tissues were examined. The T1/2 of [3H]DGalDG in plasma was 3 to 5 minutes. Of the tissues examined (liver, spleen, kidneys, lung, heart, stomach, upper and lower small intestine and colon), the liver contained the highest radioactivity per g tissue after both 15 min. and 4 h. Autoradiographic examinations after 15 min, 1 h and 4 h showed that the uptake of radiolabeled DGalDG and MGalDG occurred mainly to the hepatocytes. Less than 6 % of...
Archive | 1995
Anders Carlsson; Bengt Herslöf
Archive | 1995
Anders Carlsson; Marina Delogu; Bengt Herslöf
Archive | 1995
Arne Brodin; Anders Carlsson; Bengt Herslöf; Martin Nicklasson; Lisbeth Rydhag
Archive | 1991
Bengt Herslöf; Martin Nicklasson
Archive | 1999
Anders Carlsson; Jenny Ek; Bengt Herslöf; Goran Nilsson
Archive | 2007
Anders Carlsson; Jenny Ek; Bengt Herslöf; Ewa Karlsson; Goran Nilsson
Archive | 2003
Anders Carlsson; E K Jenny; Bengt Herslöf; Goran Nilsson
Archive | 1998
Karin Bohlinder; Anders Carlsson; Bengt Herslöf; Lars Lindmark
Archive | 1998
Karin Bohlinder; Anders Carlsson; Bengt Herslöf; Lars Lindmark