Bengt Mjöberg

Theories of wear and loosening in hip prostheses: Wear-induced loosening vs loosening-induced wear–a review

The observation of perioprosthetic granulomas containing wear debris around apparently well-fixed as well as around loose-fitting prosthetic components has led to the development of the hypothesis of wear-induced loosening. However, the hypothesis of wear-induced loosening can neither explain the rapid early prosthetic migration detected by roentgen stereophotogrammetry nor the epidemiology of clinical failure without supplementary ad hoc-assumptions. By contrast, apart from explaining the rapid early prosthetic migration detected by roentgen stereophotogrammetry, the theory of early loosening can explain the development of wear granulomas as well as to a great extent the epidemiology of clinical failure.

Measurement accuracy in acetabular cup migration: A comparison of four radiologic methods versus Roentgen stereophotogrammetric analysis☆

Four different methods of radiologic evaluation of the acetabular component migration following total hip arthroplasty have been compared with roentgen stereophotogrammetry, a proven highly accurate method for studying early migration. In the Sutherland and Wetherell method the implants position is measured with a pencil and a ruler from an ordinary pelvis radiograph. New reference lines of the Wetherell method are thought to be more accurate. The Sulzer and EBRA methods are computerized. In the Sulzer method prominent bone markers are digitized and used as reference points. In the EBRA method a system of tangents on prominent pelvis structure is digitized and used to detect radiographs with similar projection. The implants position is calculated as the mean position of similar radiographs. The Sutherland, Wetherell, and Sulzer methods had almost the same accuracy, whereas the EBRA method was more accurate and could be used for pro- and retrospective studies in a large number of patients.

Measurement accuracy in acetabular cup wear. Three retrospective methods compared with Roentgen stereophotogrammetry.

The accuracy of three methods (the simple and noncomputerized Scheier-Sandel and Charnley-Duo methods and the computerized Ein Bild Roentgen Analyse [EBRA] method) for retrospective wear measurements of the acetabular cup from standard pelvis radiographs was studied. Measurements on 13 hip prostheses were compared with those obtained by roentgen stereophotogrammetry analysis. The Scheier-Sandel method had the lowest accuracy and the EBRA method had the best accuracy. The Charnley-Duo method was almost as good when starting analysis 3 months after surgery and is easier to use. The EBRA method is useful for accurate measurements on a small number of patients; the Charnley-Duo method is recommended for clinical wear studies on a larger number of patients.

Aluminum, Alzheimer's disease and bone fragility

The incidence of fragility fractures has increased epidemically. Especially patients with senile dementia (including Alzheimers disease) have a greatly increased risk of fragility fractures. Aluminum inhibits bone mineralization; the greater the aluminium exposure, the higher the risk of an early fracture. Aluminium is neurotoxic and may, in addition to genetic factors, play a role in the development of Alzheimers disease by contributing to the formation of the characteristic beta-amyloid and neurofibrillary tangles. Thus, a common denominator between Alzheimers disease and bone fragility may be a chronic low-grade aluminum intoxication. The epidemic of fragility fractures may be caused by increased aluminium exposure--due to the use of aluminum cooking pots or the pollution acidification of our environment. In our pilot study of 26 hip-fracture patients (13 patients with Alzheimers disease and 13 individually age- and gender-matched non-demented patients), the aluminum content, determined mass-spectro-metrically, was higher in trabecular bone biopsies from the patients with Alzheimers disease than from the non-demented patients (p = 0.005). The aluminum content was also higher in the younger of the 26 patients (p = 0.02). Our findings agree with the hypothesis that aluminum plays a role in the development of Alzheimers disease and bone fragility.

Arthrosis after surgically treated acetabular fractures: A retrospective study of 60 cases

59 patients with 60 surgically treated acetabular fractures were followed up to 25 years. Coxarthrosis developed within 3 years in 23 fractured hips. There was a high correlation between nonanatomic reduction and posttraumatic arthrosis. The long-term results after an acetabular fracture can be predicted within 2-3 years of surgery.

The aluminum content of bone increases with age, but is not higher in hip fracture cases with and without dementia compared to controls

Aluminum is considered a potentially toxic metal, and aluminum poisoning may lead to three types of disorders: aluminum-induced bone disease, microcytic anemia and encephalopathy. This is well known in patients with chronic renal failure, but since healthy subjects with normal renal function retain 4% of the aluminum consumed, they are also at risk of long-term low-grade aluminum intoxication. Included in this study were a total of 172 patients (age range 16–98xa0years) with the aim of examining whether aluminum accumulates in bone with increasing age. Additionally, we aimed to investigate whether the aluminum content of bone differs between controls and hip fracture cases with and without dementia, in particular in those with Alzheimer’s disease. During operations for all cases, bone biopsies were taken with an aluminum-free instrument from the trabecular bone. The samples were measured for their content of aluminum using an inductively coupled mass spectrometer. We found an exponential increase in aluminum content of bone with age. The average aluminum values, adjusted for age, were similar in men and women (P=0.46). No significant differences in sex- and age-adjusted mean aluminum values between the controls and the hip fracture cases with (P=0.72) and without (P=0.33) dementia could be detected. The average aluminum concentration among cases with Alzheimer’s disease was also similar to the values of hip fracture patients with other types of dementia (P=0.47). Odds ratios of hip fracture for each quartile of aluminum content in bone were also estimated to detect non-linear effects, but we did not find any statistically significant association remaining after age and sex adjustment. Thus, our results indicate that we accumulate aluminum in bone over our life span, but this does not seem to be of major pathogenetic significance for the occurrence of hip fracture or dementia.

Wear and loosening of the hip prosthesis: A roentgen stereophotogrammetric 3-year study of 14 cases

Fourteen patients were followed by roentgen stereophotogrammetry for 3 years after hip arthroplasty. In 11 of the 14 acetabular components, definite wear was identified. The mean wear rate was 0.13 mm per year. There was no correlation between the wear and loosening of either the acetabular or the femoral component. Our findings indicate that products of wear do not initiate prosthetic loosening.

Infected tibial nonunion. Good results after open cancellous bone grafting in 37 cases.

We treated 37 infected tibial shaft nonunions by debridement followed by open autogenous cancellous bone grafting in a 2-stage procedure. Additional surgery was done in 21 fractures including second debridement before bone grafting and/or a second limited bone grafting and/or a split-thickness skin grafting. All fractures healed after an average of 11 (8-16) months. During 2 years follow-up there were no recurrences of the infection. Two cases of early refracture occurred, both healed following new bone grafting.

Early detection of prosthetic-hip loosening: Comparison of low- and high-viscosity bone cement

In 1987, we reported the 1-year migration of the prosthetic components in 16 hips followed by roentgen stereophotogrammetry after fixation with either low- or high-viscosity cement. We now report the migration of these prosthetic components during another 2 postoperative years. Eight acetabular components, four in each group, migrated cranially; and four femoral components, three in the low-viscosity and one in the high-viscosity group, migrated distally. All but two migrations were obvious 4 months postoperatively, which indicates that what is called late loosening is the result of late detection rather than of late occurrence of loosening. Low-viscosity cement did not provide improved prosthetic fixation.

Treatment of closed tibial shaft fractures with unilateral external fixation

Sixty-eight closed tibial shaft fractures were treated with an anterior unilateral external fixator over a 5 year period (1986-1991). Pin tract drainage and/or infection was seen in 71/380 pins. The total number of secondary operations, excluding planned pin extraction, during fracture healing was 61 (including 22 due to pin tract problems and 25 secondary corrections of alignment). Delayed union was seen in 14 fractures and non-union in three. Healing disturbances were more frequent following high-energy trauma. Bone grafting was done in 11 fractures. Eventually, all fractures healed within an average of 22 weeks. There were three refractures. At follow-up, on average 3 years after injury, functional results were excellent in 41 per cent, good in 46 and acceptable in 13 per cent. Due to the high number of unplanned secondary operations and prolonged healing times we do not consider the use of unilateral external fixation to be an adequate method for the treatment of closed tibial shaft fractures. The poor results are probably due to weight-bearing being too high in these patients relative to the mechanical stability provided by the external fixator system.