Bengu Cobanoglu

Investigation of Epstein-Barr Virus DNA in Formalin-Fixed and Paraffin- Embedded Breast Cancer Tissues

Objective: To investigate etiological role of Epstein-Barr virus (EBV) DNA in breast cancer. Materials and Methods: The presence of EBV DNA in 57 breast cancer tissues was investigated with a sensitive PCR assay. The breast cancer tissues were from invasive ductular (n = 28), lobular (n = 20) and other miscellaneous carcinomas (n = 9). Tissues from normal breasts and patients with various benign breast diseases (n = 55): fibrocystic disease (n = 34), fibroadenoma (n = 16), hyperplasia, and granulomatous mastitis (n = 5), were used as control samples. Results: EBV DNA was detected in 13 (23%) cancerous tissues (7 ductular, 4 lobular, 2 other carcinoma) and 19 (35%) in the control tissues. The difference between EBV presence in malignant and benign tissues was not statistically significant (p > 0.05). Conclusion: The presence of EBV DNA was detected almost equally in both breast cancer and normal tissues, which indicates no etiological role for EBV in breast cancer. We suggest further etiological studies.

Recurrent Retroperitoneal Cystic Lymphangioma.

Retroperitoneal cystic lymphangioma is a rare congenital malformation. The majority of lymphangiomas are present at birth and nearly all present before the age of two years. We report a case of giant cystic retroperitoneal lymphangioma in a patient who first presented with symptoms at the age of 7, underwent surgery, and who then suffered a recurrent mass 11 years later.

Multiple metastatic tuberculosis abscesses in a patient with Pott disease and lung tuberculosis: a case report

Abstract:  The incidence of tuberculosis in Western countries is rising, and continued vigilance together with an awareness of its protean manifestations is essential. Cutaneous tuberculosis is a relatively rare manifestation of the disease, accounting for only 1% of extrapulmonary cases of tuberculosis and 0.14% of all reported cases of tuberculosis. A 19‐year‐old male patient was admitted to our clinic with skin lesions both at the front and at the back of his body. With clinical findings, histopathology, polymerase chain reaction, PA lung graph, and computerised tomography, the patient was diagnosed with metastatic tuberculosis abscess associated with lung tuberculosis and Potts disease. Antituberculosis drugs were administered. An increased awareness of the re‐emergence of cutaneous tuberculosis will allow for the proper diagnosis and management of this increasing common skin disorder.

Primary Cutaneous Rhabdomyosarcoma in an Adult

Rhabdomyosarcomas (RMSs) are primitive malignant mesenchymal tumors that have a strong tendency to differentiate into skeletal muscle. They have a predilection for the head and neck region, the genitourinary tract, the retroperitoneum, and the soft tissues of the extremities. They are the most common soft tissue sarcoma of childhood. Rarely, RMSs may present as dermal nodules, particularly on the head or neck, usually as a result of dermal extension of a lesion arising in the underlying soft tissues. Lesions of dermal origin are rare.

An urticarial vasculitis case induced by glatiramer acetate

Urticarial vasculitis (UV) is a disease characterized clinically by urticarial skin lesions and histologically by leukocytoclastic vasculitis caused by immunocomplex accumulation in post‐capillary venules. Cases induced by various drugs such as cimetidine, diltiazem, potassium iodide, fluoxetine, and non‐steroid inflammatory drugs have been reported in the literature. A 48‐year‐old female who developed pruritus and rash on her body 3 months after starting glatiramer acetate (GA) treatment for multiple sclerosis was diagnosed with UV after clinical and histopathological examination. This report presents the first case in the literature of UV induced by GA.

Pleomorphic Rhabdomyosarcoma Arising from True Vocal Fold of Larynx: Report of a Rare Case and Literature Review

We present an extremely rare case of a pleomorphic rhabdomyosarcoma of the true vocal fold. The histopathological diagnosis was confirmed by immunohistochemistry. The patient was treated with radical surgery including total laryngectomy and radical neck dissection followed by postoperative radiotherapy. The clinicopathologic features of this rare malignancy are discussed together with a review of the literature. This case report and literature review highlights the more favorable prognosis of pleomorphic rhabdomyosarcoma in the larynx than in other locations.

Calcium Acetate-Induced Linear Fixed Drug Eruption

Introduction Fixed drug eruption (FDE) is a common dermatological disease, and its mechanism is currently uncertain. It develops after intake of a responsible drug and always occurs at the same sites [1]. Lesions are egg-shaped or circular with sharp borders and emerge within hours after administration of the drug. Initially they have a dark red color, but their color fades within 7–10 days and they recover with postinflammatory hyperpigmentation [1, 2]. Hyperpigmented lesions may persist for months or years. Pigmentation may increase in later episodes. Recurrence of the lesion at the same site after intake of the same drug is diagnostic. Lesions are most frequently found on the trunk, upper part of extremities and penis [1, 2]. Drugs that most frequently cause FDE are cotrimoxazole, phenolphthalein and nonsteroidal anti-inflammatory drugs [3]. Calcium acetate is used for hyperphosphatemia due to chronic renal failure. Its most common side effects are nausea, vomiting and diarrhea. However, no dermatological side effects have been reported so far. In the present study, we present a case of FDE due to calcium acetate that was linearly arranged.

A very rare side effect of mitomycin-C: psoriasiform drug eruption

Various topical preparations have been used with variable success, including topical steroids, calcineurin inhibitors, retinoids, and clindamycin. Oral contraceptives and oral isotretinoin have also been used, but none produced long-lasing results, and lesions tend to recur once treatment is stopped. Physical therapies including electrocautery, liposuction-assisted curettage, and surgical excision can be done as a last option. Fractional photothermolysis is a recently introduced technology in the field of ablative lasers. Fractional lasers produce microscopic treatment zones (MTZ). The depth and width of MTZ increases with using higher energy levels. The percentage of area covered by fractional lasers is also variable, but leaving microscopic untreated areas will speed healing and reduce down time and risk of complications. The use of fractional lasers in the treatment of Fox– Fordyce disease has not been described before, and to the best of our knowledge, this is the first case report using fractional CO2 laser treatment of this difficult-to-treat condition. In conclusion, we think that fractional CO2 laser may be a treatment option for Fox–Fordyce disease based on the results we have seen in our patient, especially for patients that have tried conventional treatments without good response. Of course this has to be substantiated by further studies including a larger number of patients.

Presence of a meningioma in a cervical myelomeningocele sac

SummaryAn 11-year-old female, presented with a cervical myelomeningocele. Interestingly, the myelomeningocele sac was seen to contain a meningioma. There are no aetiological factors in the embryogenetic period that would lead to such a combination of lesions. In our opinion, the meningioma appeared in a later period because of local factors.

Giant ulcerative dermatofibroma.

Dermatofibroma is a slowly growing common benign cutaneous tumor characterized by hard papules and nodules. The rarely seen erosions and ulcerations may cause difficulties in the diagnosis. Dermatofibrosarcoma protuberans, which is clinically and histopathologically of malignant character, displays difficulties in the diagnosis since it has similarities with basal cell carcinoma, epidermoid carcinoma, and sarcomas. Head and neck involvement is very rare. In this study, a giant dermatofibroma case, which is histopathologically, ulcerative dermatofibroma, the biggest lesion of the head and neck region and seen rarely in the literature that has characteristics similar to dermatofibrosarcoma protuberans, has been presented.