Bengul Gunalp

Clinicopathologic features and prognostic factors of tall cell variant of papillary thyroid carcinoma: comparison with classic variant of papillary thyroid carcinoma.

ObjectiveTall cell variant (TCV), an aggressive form of papillary thyroid carcinoma (PTC), frequently presents with extrathyroidal disease and recurrence. The aim of this study was to evaluate the clinicopathologic features and outcomes of patients with TCV by comparing them with a larger group of patients with classic variant of papillary thyroid carcinoma (cPTC). Patients and methodsA total of 2500 patients with differentiated thyroid carcinoma were treated and monitored during a 23-year period (1992–2015). Of them, 2250 (90%) had PTC and 235 (9.5%) had follicular thyroid carcinoma. Of the 2250 patients, 862 (38.3%) and 70 (3.1%) had cPTC and TCV, respectively. Cases of TCV and cPTC of PTC were compared on the basis of risk factors. ResultsPatients with TCV were significantly older compared with cPTC patients (P<0.001). Tumor size was significantly bigger (P=0.01) and preablation thyroglobulin level was significantly higher (P<0.001) in TCV patients than in cPTC patients. The incidence of capsule invasion, extrathyroidal extension, and vascular invasion was significantly higher in TCV (P=0.003, <0.001, and 0.011, respectively). The incidence of initial lymph node metastasis was significantly higher in TCV (P<0.001). Patients with TCV were mostly at an advanced stage compared with patients with cPTC (P<0.001). Development of local or distant metastasis during the follow-up was significantly higher in TCV than in cPTC. Sex and multifocality were not statistically significant. ConclusionTCV has a higher incidence of local or distant metastasis and mortality rate. Thus, it must be treated with the highest possible 131I ablation doses and followed up carefully.

Combined Tc-99m MDP and Tc-99m labeled RBC imaging in a case of Maffucci's syndrome.

AbstractMaffuccis syndrome is characterized by multiple enchondromas combined with hemangiomas and less commonly lymphangiomas. The extent of skeletal involvement is variable in this rare nonhereditary syndrome, but the most frequent sites of enchondromas are the metacarpals and the phalanges of th

Radiation Safety Process for the Patient and People Around during Diagnostic Radionuclide Studies

Feray Aras1, Suna Kıraç2, Aslı Ayan3, Meral Değer4, Mustafa Demir5, Semra Dönmez3, Bengül Günalp3, Mehmet İnce6, Bilal Kovan7, Kamil Köseoğlu8, İnci Alıç Özaslan9, Leyla Poyraz7, Türkay Toklu10, Bağnu Uysal11, Nami Yeyin5 1Celal Bayar Üniversitesi Tıp Fakültesi, Nükleer Tıp Anabilim Dalı, Manisa, Türkiye 2Yakın Doğu Üniversitesi Tıp Fakültesi, Nükleer Tıp Anabilim Dalı, Lefkoşa, KKTC 3T.C. Sağlık Bakanlığı Gülhane Eğitim ve Araştırma Hastanesi, Nükleer Tıp Kliniği, Ankara, Türkiye 4Marmara Üniversitesi Pendik Eğitim ve Araştırma Hastanesi, Nükleer Tıp Kliniği, İstanbul, Türkiye 5İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Nükleer Tıp Anabilim Dalı, İstanbul, Türkiye 6Epsilon Elektronik, İstanbul, Türkiye 7İstanbul Üniversitesi İstanbul Tıp Fakültesi, Nükleer Tıp Anabilim Dalı, İstanbul, Türkiye 8Ege Üniversitesi Tıp Fakültesi, Nükleer Tıp Anabilim Dalı, İzmir, Türkiye 9Üsküdar Devlet Hastanesi, Nükleer Tıp Kliniği, İstanbul, Türkiye 10Yeditepe Üniversitesi Tıp Fakültesi, Nükleer Tıp Anabilim Dalı, İstanbul, Türkiye 11Dokuz Eylül Üniversitesi Tıp Fakültesi, Nükleer Tıp Anabilim Dalı, İzmir, Türkiye *Üçüncü ve sonraki sırada yer alan yazarlar soy ismi sırasına göre yazılmıştır Nuclear Medicine Seminars / Nükleer Tıp Seminerleri 2016;3:172-175 UYGULAMA KILAVUZU DOI:10.4274/nts.024