Benjamin J. Shore

Efficacy of periarticular multimodal drug injection in total knee arthroplasty. A randomized trial.

BACKGROUND Postoperative analgesia with the use of parenteral opioids or epidural analgesia can be associated with troublesome side effects. Good perioperative analgesia facilitates rehabilitation, improves patient satisfaction, and may reduce the hospital stay. We investigated the analgesic effect of locally injected drugs around a total knee prosthesis. METHODS Sixty-four patients undergoing total knee arthroplasty were randomized either to receive a periarticular intraoperative injection containing ropivacaine, ketorolac, epimorphine, and epinephrine or to receive no injection. The perioperative analgesic regimen was standardized. All patients in both groups received patient-controlled analgesia for twenty-four hours after the surgery, and this was followed by standard analgesia. Visual analog scores for pain, during activity and at rest, and for patient satisfaction were recorded preoperatively and postoperatively and at the six-week follow-up examination. The consumption of patient-controlled analgesia at specific postoperative time-points and the overall analgesic requirement were measured. RESULTS The patients who had received the injection used significantly less patient-controlled analgesia at six hours, at twelve hours, and over the first twenty-four hours after the surgery. In addition, they had higher visual analog scores for patient satisfaction and lower visual analog scores for pain during activity in the post-anesthetic-care unit and four hours after the operation. No cardiac or central nervous system toxicity was observed. CONCLUSIONS Intraoperative periarticular injection with multimodal drugs can significantly reduce the requirements for patient-controlled analgesia and improve patient satisfaction, with no apparent risks, following total knee arthroplasty.

Chronic Posttraumatic Elbow Disorders Treated with Metallic Radial Head Arthroplasty

BACKGROUND Metallic radial head arthroplasty is a proven technique for the treatment of complex radial head fractures. The purpose of this study was to evaluate the functional outcomes of a metallic radial head arthroplasty in patients with chronic posttraumatic elbow disorders. METHODS The results of thirty-two metallic radial head arthroplasties in thirty-two consecutive patients were retrospectively reviewed. The indications for the radial head arthroplasty included posttraumatic nonunion and malunion of the radial head, elbow instability following previous excision of the radial head, and failure of a silicone radial head implant used to treat an acute radial head fracture. The study included thirteen male and nineteen female patients followed for a minimum of two years. The radial head arthroplasties were performed at an average of 2.4 years after the injury. Analysis included chart review, personal interview, physical examination, radiographic examination, and strength testing as well as the administration of general and region-specific questionnaires. RESULTS The mean duration of follow-up was eight years. The average Mayo Elbow Performance Score was 83 of 100 points, with seventeen (53%) of the thirty-two results rated as excellent; four (13%), as good; seven (22%), as fair; and four (13%), as poor. The average score for subjective patient satisfaction was 8.5 points on a 10-point scale. Patients had significantly less motion and strength in the affected elbow than in the unaffected elbow. Seventy-four percent of the patients demonstrated some degree of posttraumatic arthritis. There were no significant differences in ulnar variance and the ulnohumeral joint space between the affected and unaffected arms. Over the course of the study, no metallic radial head arthroplasties required revision. CONCLUSIONS Metallic radial head arthroplasty for the treatment of posttraumatic elbow disorders appears to be a safe and durable procedure that can provide a functional range of motion and pain relief for at least five to ten years. However, longer follow-up is needed to evaluate progression of lucencies adjacent to stems and osteoarthritis.

Single-event multilevel surgery for children with cerebral palsy: a systematic review

Aim  To conduct a systematic review of single‐event multilevel surgery (SEMLS) for children with cerebral palsy, with the aim of evaluating the quality of the evidence and developing recommendations for future research.

Overcoming the Funding Challenge: The Cost of Randomized Controlled Trials in the Next Decade

Randomized controlled trials (RCTs) represent the gold standard of evidence-based medicine. However, over the last several decades, the cost associated with conducting RCTs has increased dramatically. Several factors contribute to higher costs associated with clinical trials. This paper describes important barriers to conducting surgical RCTs, identifies funding sources available to finance RCTs, and suggests strategies to maintain cost-efficient study practices as we move into the next decade.

The role for hip surveillance in children with cerebral palsy

Spastic hip displacement is the second most common deformity seen in children with cerebral palsy (CP), and the long-term effects can be debilitating. Progressive hip displacement leading to dislocation can result in severe pain as well as impaired function and quality of life. Recent population-based studies have demonstrated that a child’s Gross Motor Functional Classification System (GMFCS) level is most predictive for identifying hips “at-risk” for progressive lateral displacement. As a result, in many developed countries, hip surveillance has now been adopted as an integral piece of the comprehensive care puzzle for the management of children with spastic hip displacement. This paper reviews the spectrum of treatments available for progressive hip displacement, examines the current literature on the success of hip surveillance, and illustrates an example of a current hip surveillance program stratified by the GMFCS level.

Acute compartment syndrome in children and teenagers with tibial shaft fractures: incidence and multivariable risk factors.

Objectives: To identify the incidence of acute compartment syndrome (ACS) in children and teenagers with tibial shaft fractures and report associated risk factors. Design: Retrospective Case Control. Setting: Level 1 pediatric trauma hospital. Patients/Participants: Two hundred sixteen tibial shaft fractures in 212 patients (160 males and 52 females; median age, 13 years) over a 5-year period were reviewed. Intervention: One hundred thirty-two (61%) fractures were treated with closed reduction and casting, 36 with external fixation, 27 with locked intramedullary nails, and 21 with flexible intramedullary nails. Main Outcome Measures: ACS was diagnosed clinically or by intracompartment pressure. Multivariable logistic regression analysis tested age, gender, weight, physeal status, mechanism of injury, time to surgery, fracture type, and treatment intervention as possible risk factors for development of ACS. Results: There were 25 (11.6%) cases of ACS. Multivariable predictors of ACS included age of 14 years and older (22/96 = 23% vs. 3/120 = 3%, P < 0.001) and motor vehicle accident (MVA) (13/57 = 23% vs. 12/159 = 8%, P < 0.001). Incidence of ACS was 48% among patients aged 14 years and older, who sustained MVA (12/25). Gender, physeal status, time to surgery, and surgical fixation were not predictive of ACS. Conclusions: This is the largest study in children and teenagers reporting the incidence of ACS from tibial shaft fractures. The incidence of 11.6% is higher than previously reported and much higher in patients older than14 years of age and involved in an MVA. Surgeons should be especially aware and suspicious of this diagnosis in teenagers with tibial shaft fractures. Level of Evidence: Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.

Pediatric pelvic fracture: a modification of a preexisting classification.

Background: The classic pediatric pelvic fracture (PPF) classification was developed by Torode and Zeig in 1985 and is based exclusively on plain radiographs. The purpose of this study was to propose a modification to a previously accepted PPF classification scheme and discuss the significance of this modification with respect to treatment and management of PPF over an 8-year period at a large pediatric hospital. Methods: PPFs were recorded on a prospectively identified hospital registry of all trauma admissions. Pelvic x-rays and computerized tomography scans were reviewed and classified according to a modified classification scheme. Correlation was made with age, sex, mechanism, associated injuries, intensive care unit stay, operations, and discharge outcome. Blood product usage was obtained from a hematology database. Results: A total of 124 children were identified with PPF, comprising 1.6% of trauma admissions between July 2000 and June 2008. Radiology was available for 115 children (58 boys, and 57 girls, mean age 11.5 y). According to the modified classification, 71% (82/115) had type III-A or III-B injuries (type I=5 children, type II=17 children, type IV=11 children). There was a mortality of 5% (6/115 children) during the study. Eighty-one percent (93/115) of PPF resulted from being involved in a motor vehicle accident (occupant or pedestrian). Trend testing showed relationships between increasing fracture type and length of stay (P<0.001), as well as the need for blood transfusion (P=0.009) or pelvic operation (P<0.001). A total of 34 (30%, 34/115) children required blood products. Type III-B injuries were more likely to receive blood products than type III-A injuries (odds ratio 3.58; 95% confidence interval, 1.28-10.03). Conclusions: The modified Torode PPV classification is predictive for significant morbidity and death in the setting of multitrauma. Stable type III-B fractures are indicative of increased blood product use, intensive care unit requirement, and overall hospital stay. This modified classification scheme will aid health care providers at all levels in managing PPF more efficiently during their initial resuscitation and treatment period. Levels of Evidence: Level III—retrospective case control study.

Severe crouch gait in spastic diplegia can be prevented: a population-based study

We studied the prevalence of severe crouch gait over a 15-year period in a defined population of children with spastic diplegia and Gross Motor Function Classification System levels II and III, to determine if there had been a decrease following changes to the management of equinus gait. These changes were replacing observational with three-dimensional gait analysis, replacing single level with multilevel surgery, and replacing gastrocsoleus lengthening with gastrocnemius recession. Of 464 children and adolescents with spastic diplegia who underwent three-dimensional gait analysis, 27 had severe crouch gait. Seventeen of these had been managed by isolated lengthening of the gastrocsoleus. Following changes in the management of equinus gait, the prevalence of severe crouch gait decreased from 25% and stabilised at a significantly lower rate, fluctuating between 0% and 4% annually (p < 0.001). We conclude that severe crouch gait in this population was precipitated by isolated lengthening of the gastrocsoleus. These findings may be relevant to other surgical populations, as severe crouch gait may be a useful way to monitor the quality of the surgical management of abnormal gait in children with cerebral palsy and spastic diplegia.

Epidemiology and prevention of cast saw injuries: results of a quality improvement program at a single institution.

BACKGROUND An investigation was conducted to establish the hospital-wide prevalence of cast saw injuries and to identify variables that put patients at increased risk, with the goal of reducing the injury rate. METHODS Information was collected from January 2010 through December 2012 on all patients who had a cast removed or cut at our institution. Locations included the operating suites, emergency department, ambulatory clinics, and hospital floors. A cast cutting log was used to capture the total number of casts cut. An adverse event form was used to document each injury. A continuous quality improvement approach was used throughout the study period to implement incremental improvements to our program. Changes included an education and certification program on cast saw use for all providers, a protocol for a plastic surgery consultation, and a cast saw blade inspection protocol with maintenance logs. RESULTS Twenty-nine injuries occurred in 23,615 cast cuttings over the three years, for an overall rate of 1.23 (95% confidence interval [CI], 0.86 to 1.76) per 1000. A minor decrease in cast saw injuries was recorded over the course of the study (eleven of 8043 [1.37 per 1000] in 2010, ten of 7885 [1.27 per 1000] in 2011, and eight of 7687 [1.04 per 1000] in 2012), but the decrease was not significant (p = 0.87). The emergency department had the highest rate of cast saw injuries (p < 0.0001), with a significantly greater rate during the night compared with the day (eleven of 1293 [8.51 per 1000] compared with fifteen of 19,419 [0.77 per 1000], respectively; p < 0.0001). The injuries were all minor. Key risk factors for a cast saw injury included provider inexperience, patient sedation, and poor cast saw blade condition. CONCLUSIONS The rate of cast saw injuries in a busy pediatric orthopaedic department was small, but a considerably increased risk existed for those patients cared for in the emergency department by orthopaedic residents. Improving education and training in cast saw use has the potential to decrease the prevalence of cast saw injuries over time.

Proximal Femoral Varus Derotation Osteotomy in Children with Cerebral Palsy: The Effect of Age, Gross Motor Function Classification System Level, and Surgeon Volume on Surgical Success.

BACKGROUND The purpose of this study was to evaluate mid-term results of proximal femoral varus derotation osteotomy (VDRO) in children with cerebral palsy and determine what effect age, Gross Motor Function Classification System (GMFCS) level, and surgeon volume had on surgical success. METHODS We analyzed a cohort of children with cerebral palsy who underwent VDRO for hip displacement at a tertiary-level pediatric hospital between 1994 and 2007. Age, sex, GMFCS level, preoperative radiographic parameters, previous botulinum toxin administration or soft-tissue release, adjunctive pelvic osteotomy, the performance of bilateral surgery at the index VDRO, and surgeon volume (the number of procedures performed) were recorded. Results were analyzed via univariate and multivariate analyses for association with the need for revision hip surgery. Kaplan-Meier survivorship curves were generated, determining the time from index surgery to failure (defined as the need for subsequent surgical procedures on the hip and/or pelvis, or a hip migration percentage of >50% at the time of final follow-up), and were further stratified according to osseous versus soft-tissue revision. RESULTS A total of 567 VDROs were performed in 320 children (mean age [and standard deviation], 8.2 ± 3.8 years). The mean follow-up was 8.3 years (range, three to eighteen years). Of the initial 320 patients, 117 (37%) were considered to have had failure. Multivariate Cox regression analysis confirmed that younger age at surgery (p < 0.001), increased GMFCS level (p = 0.01), and lower annual surgical hip volume (p = 0.02) were significant independent predictors of any type of surgical revision. Furthermore, soft-tissue release at VDRO was protective against revision (p = 0.02). Five-year survivorship analysis revealed a 92% success rate for children classified as GMFCS levels I and II compared with a 76% success rate for those of GMFCS level V (p < 0.01). CONCLUSIONS This study demonstrated a 37% failure rate after VDRO in children with cerebral palsy. Older age, lower GMFCS level, and increased surgeon volume were strong predictors of surgical success.