Benjamin T. Gordon
University of South Carolina
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Featured researches published by Benjamin T. Gordon.
Journal of Interferon and Cytokine Research | 2011
E. Angela Murphy; J. Mark Davis; Jamie L. McClellan; Benjamin T. Gordon; Martin D. Carmichael
Curcumins benefits on tumorigenesis are thought to be mediated by its antiinflammatory activity; however, these effects have not been well characterized in a mouse model of colon cancer. We examined the effects of curcumin on intestinal inflammation in the Apc(Min/+) mouse. Apc(Min/+) mice were given a placebo or curcumin (2%) diet from 4 to 18 weeks of age (n = 10/group). C57BL/6 mice were used as a wild-type control (n = 10/group). Intestines were analyzed for polyp burden (sections 1, 4, and 5) and for mRNA expression, and concentration of interleukin (IL)-1β, IL-6, tumor necrosis factor-α, and chemokine ligand 2 (CCL2) (sections 2 and 3). Plasma was collected for concentration of CCL2. Curcumin decreased total intestinal polyps by 75% (P < 0.05) in all size categories [>2 mm (65%), 1-2 mm (72%), <1 mm (82%); P < 0.05]. mRNA expression of IL-1β, IL-6, tumor necrosis factor-α, and CCL2 was elevated (P < 0.05) and curcumin blunted this increase (P < 0.05). Protein concentration of IL-1β, IL-6 (section 3), and CCL2 was increased (P < 0.05) and curcumin reduced this response for IL-1β (section 2) and CCL2 (P < 0.05). Curcumin also offset the increase in plasma CCL2 (P < 0.05). The benefits of curcumin in colon cancer may be at least in part mediated by its antiinflammatory activity.
Current Sports Medicine Reports | 2014
Benjamin T. Gordon; Stephen C. Chen; J. Larry Durstine
The purpose of this review is to provide up-to-date information regarding the effects of aerobic and resistance exercise training on the traditional blood lipid and lipoprotein profile. In addition, emerging coronary artery disease (CAD) risk factors, such as postprandial lipemia (PPL) and metabolic syndrome (MetS), are reviewed. Numerous studies report that aerobic exercise combined with weight loss significantly reduces blood cholesterol, low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), and triglycerides (TG) while improving high-density lipoprotein cholesterol (HDL-C). Both aerobic and resistance training demonstrated a reduction in non-HDL-C independent of changes in body weight. Transient beneficial effects of a single session of aerobic exercise are observed for PPL. Nonetheless further research is needed to provide a better understanding of the potential mechanisms for reducing PPL. Exercise as an intervention for patients with MetS leads to improved CAD risk factors including atherogenic dyslipidemia, blood pressure, body composition, insulin sensitivity, and fat metabolism.
Journal of Sport and Health Science | 2013
J. Larry Durstine; Benjamin T. Gordon; Zhengzhen Wang; Xijuan Luo
Medicine and Science in Sports and Exercise | 2015
Benjamin T. Gordon; Daniel P. O’Connor; Gregory A. Hand; Robin P. Shook; Clemens Drenowatz; Steven N. Blair
Archive | 2014
Benjamin T. Gordon
The Encyclopaedia of Sports Medicine: An IOC Medical Commission Publication, Volume 19 | 2013
J. Mark Davis; Benjamin T. Gordon; E. Angela Murphy; Martin D. Carmichael
Journal of Clinical Exercise Physiology | 2013
Benjamin T. Gordon; J. Larry Durstine
The FASEB Journal | 2012
Benjamin T. Gordon; Jamie L. McClellan; E. Angela Murphy; Martin D. Carmichael; J. Mark Davis
The FASEB Journal | 2012
Benjamin T. Gordon; Jamie L. McClellan; E. Angela Murphy; Martin D. Carmichael; J. Mark Davis
Medicine and Science in Sports and Exercise | 2011
Benjamin T. Gordon; Angela Murphy; Jamie L. McClellan; Martin D. Carmichael; Mark J. Davis