Berna Şanli

Psychiatric Disorders in Patients Attending a Dermatology Outpatient Clinic

Background: Psychiatric comorbidity in patients with skin disorders has been reported. Objective: To find out the prevalence of psychiatric disorders in dermatology outpatients and to investigate the factors that affect the psychiatric symptoms. Methods: 256 patients attending our dermatology outpatient clinic completed a 12-item General Health Questionnaire (GHQ) following their dermatologic examination. A standardized personal interview was performed to establish a psychiatric diagnosis in patients sampled by using a stratified random sampling method. Results: The prevalence of psychiatric disorders was found to be 33.4% in the study group. The mean of the total GHQ scores of the sample group (n = 256 patients) was 3.656. The duration of the dermatologic complaints, sex of the subjects, localization of the lesions, and dermatologic diagnosis did not affect the total GHQ scores of the patients. Conclusion: Psychiatric comorbidity in 33.4% of the dermatology outpatients indicates the need for considering emotional factors for an effective management of the cutaneous disorders.

Dermatoscopy for monitoring treatment of actinic keratosis with imiquimod.

patients. J Dermatolog Treat 2011; DOI: 10.3109/0954 6634.2010.544707. 2 Della Monica A, Ioli A. Profilo farmacologico e clinico dell albendazolo. Riv Parassitol 1986; 3: 143–51. 3 Meneghelli UG, Martinelli AL, Bellucci AD et al. Polycystic hydatid disease (Echinococcus vogeli). Treatment with albendazole. Ann Trop Med Parasitol 1992; 86: 151–6. 4 Steiger U, Cotting J, Reichen J. Albendazole treatment of echinococcosis in humans: effects on microsomal metabolism and drug tolerance. Clin Pharmacol Ther 1990; 47: 347–53. 5 Saimot AG. Medical treatment of liver hydatidosis. World J Surg 2001; 25: 15–20. 6 Dewerdt S, Machet L, Jan-Lamy V et al. Stevens-Johnson syndrome after albendazole. Acta Derm Venereol 1997; 77: 411. 7 Garcı́a-Muret MP, Sitjas D, Tuneu L, de Moragas JM. Telogen effluvium associated with albendazole therapy. Int J Dermatol 1990; 29: 669–70.

Conjunctival impression cytology, ocular surface and tear-film changes in patients with lichen planus

Background.  Lichen planus (LP) is an immune‐mediated chronic mucocutaneous disease. Rarely, LP affects the conjunctiva, resulting in conjunctival inflammation, cicatrization and scarring of the subepithelium and cornea, causing keratitis and keratoconjunctivitis sicca. To date, there has been no case–control study examining the ocular findings in LP.

The investigation of the possible relationship between Coxsackie viruses and pemphigus

Pemphigus is a group of autoimmune bullous diseases on which the etiopathogenesis of several viruses has been blamed. Coxsackie viruses (CVs) are the causative agents of hand, foot, and mouth disease, and herpangina, which have been strongly associated with several autoimmune diseases. The onset of pemphigus after CV infection and cephalosporin use has been reported.

Analysis of clinical and histopathological findings of PAS positive dermatophytose cases

Purpose: In most cases, dermatophytosis is diagnosed routinely without histopathological examination. Spongiotic or psoriasiform features are frequently found in fungal dermatoses but these histopathological findings are not proficient for diagnosis. The aim of the study is to identify characteristic histopathogical clues and to emphasize the diagnostic significance of dermatophytosis stained with histochemical method of Periodic acid-Schiff [PAS]. Materials and methods: In this study; PAS and Hematoxylin and eosin [H&E] stained slides and their clinical parameters of 19 dermatophytose cases confirmed by PAS stain were reevaluated. We compared histopathological and histochemical findings with clinical findings of all cases. Results: Fungal microorganisms were identified with PAS stained slides in 68.4 % cases in which fungal infection had not been suspected clinically. We detected perifolliculitis in all endothrix infection visualised cases. This finding and the presence of parakeratosis were significant for fungal infections. Conclusion: Therefore, histochemical PAS stain is required for fungal diagnosis in any spongiotic or psoriasiform dermatitis. Also, the presence of parakeratosis and endothrix as well as the perifolliculitis findings should be kept in mind as helpful pathologic clues to facilitate an accurate diagnosis of dermatophytic infections. Pam Med J 2015;8(3):171-177

Influence of narrowband UVB irradiation of serum on autologous serum skin test results.

Background  Autologous serum skin test (ASST) is an in vivo test to demonstrate circulating endogenous proinflammatory or wheal‐inducing factors in urticaria patients. While ASST was negative in a patient with solar urticaria and in a patient with localized heat urticaria, test results turned to positive when performed with visible light‐irradiated and heated serums, respectively. These data suggest that some factors and/or antibodies in serum may be activated or inhibited with different factors. We aimed to investigate whether or not ASST results change when performed with narrowband ultraviolet B (UVB)‐irradiated serum.