Bernard Malézieux

Enzymatic generation of planar chirality in the (arene)tricarbonylchromium series

Abstract Hydrolysis using pig liver esterase of the meso diesters [ortho-C 6 H 6 (CH 2 CO 2 R) 2 ]-Cr(CO) 3 (R = Me,Et) yields the half ester in good yield and high enantiomeric excess.

Synthesis and reactivity of a transition metal-carbonyl imidoester designed for the selective and covalent labelling of biological macromolecules

Abstract The first transition metal-carbonyl water-soluble imidoester has been prepared in several steps and characterised by classical spectroscopic methods. It is aimed at the selective conjugation of amine-containing biomolecules such as proteins in aqueous medium, leading to conjugates that retain their net charge. A preliminary reactivity study with bovine serum albumin (BSA) is reported.

Preparation, isolation and chemical reactivity of the α-CF3-propargylium ion stabilized by a heterobimetallic [CoMo] cluster

Abstract The synthesis of a diastereomeric α-CF 3 derivative of a propargylic alcohol complexed in a hetero-bimetallic [CoMo] cluster is described. By the action of HBF 4 on the alcohol, one variety of complexed propargylium ion is formed.

Enzymatic generation of planar chirality in the (arene)Cr(CO)3 series: experimental results and modelling studies

Abstract Hydrolysis using pig liver esterase of (benzene-1,2-diacetic ester)Cr(CO) 3 complexes generates the half-ester in high enantiomeric purity. The high enantioselectivity may be rationalised through substrate interaction with the Jones active site model of pig liver esterase.

Optically active molecular magnets

We describe the synthesis of two-dimensional {[MnIICrIII(C2O4)3]C} bimetallic networks that include as template cations C stilbazolium salts 4-[4-(N,N-dimethylamino)-α-styryl]-N-alkylpyridinium with alkyl = methyl (DAMS), 4-[4-methoxy- α-styryll-N-isopentylpyridinium (MIPS), and DAZOP, which is a DAMS analogue with the central [C=C] core replaced by an azo N=N] moiety. These networks are obtained in their optically active forms, using the resolved - or Λ- [CrIII(C204)3]3- anionic bricks as chiral-inducing reagents. The UV-visible properties of the networks and their natural circular dichroism (Cotton effects) demonstrate that the MIPS, DAZOP, and DAMS become chiral in [MnIICrIII (C204)3]- anionic matrices. The absolute configurations of the template cations inside the anionic framework depend on the configuration of the starting anionic reagent.