Bernd Grimm

Acceleration-based gait test for healthy subjects: Reliability and reference data

Accelerometers enable us to analyse gait outside conventional gait laboratories. Before these devices can be used in large scale studies and in clinical settings a thorough evaluation of their performance in different populations is required. The aim of this study was to present an acceleration-based reference database for healthy gait. The repeatability and inter-observer reliability of acceleration-based gait analysis was investigated. The sensitivity was tested on different age groups and the effect of gender was studied. A comprehensive set of gait parameters (i.e. cadence, speed, asymmetry and irregularity) were studied in 60 women and 60 men. Basic gait parameters showed high repeatability (VC(cadence) 1.51%, ICC(cadence) 0.996) and inter-observer reliability (ICC(cadence) 0.916), while asymmetry and irregularity showed lower repeatability (VC(asym) 47.88%, ICC(asym) 0.787) and inter-observer reliability (ICC(asym) 0.449). The effects of age and gender on gait parameters were found to be consistent with those reported in studies using other methodologies. These findings and the advantages of the device support the application of AGA for routine clinical use and in daily life.

Crosslinked polyethylene compared to conventional polyethylene in total hip replacement : Pre-clinical evaluation, in-vitro testing and prospective clinical follow-up study

Background Polyethylene wear-induced osteolysis is a major cause of implant loosening in total hip arthroplasty. New crosslinked polyethylenes are presumed to give lower wear rates, but no long-term clinical results are available yet. Patients and methods We compared basic material characteristics and MTS hip joint simulator wear rates of a crosslinked polyethylene (Duration) to those of conventional polyethylene. In a randomized double-blind 5-year clinical follow-up study, 133 hips (67 conventional, 66 Duration) in 127 patients were followed-up for an average of 5 (3–6) years. Wear rates were measured using a computer-based edge detection method. The radiographic appearances of wear-related phenomena were recorded. Results The Duration polyethylene showed a significantly lower in-vitro wear rate in the simulator study (mean 22 (SD 2.3) vs. 40 (SD 1.5) mm3/106 cycles). Also, the in-vivo wear was lower for Duration (mean 0.083 (SD 0.056) mm/year) than for conventional polyethylene (mean 0.123 (SD 0.082) mm/year). All radiographic signs of osteolysis were less frequent in the Duration group. Interpretation Our study has given a substantial body of evidence—from lower wear rates, less frequent signs of osteolysis, and higher survival rates after a mean follow-up of 5 years—that Duration provides better clinical outcomes than conventional polyethylene.

Accelerometry-based gait analysis, an additional objective approach to screen subjects at risk for falling ☆

This study investigated whether the Tinetti scale, as a subjective measure for fall risk, is associated with objectively measured gait characteristics. It is studied whether gait parameters are different for groups that are stratified for fall risk using the Tinetti scale. Moreover, the discriminative power of gait parameters to classify elderly according to the Tinetti scale is investigated. Gait of 50 elderly with a Tinneti>24 and 50 elderly with a Tinetti≤24 was analyzed using acceleration-based gait analysis. Validated algorithms were used to derive spatio-temporal gait parameters, harmonic ratio, inter-stride amplitude variability and root mean square (RMS) from the accelerometer data. Clear differences in gait were found between the groups. All gait parameters correlated with the Tinetti scale (r-range: 0.20-0.73). Only walking speed, step length and RMS showed moderate to strong correlations and high discriminative power to classify elderly according to the Tinetti scale. It is concluded that subtle gait changes that have previously been related to fall risk are not captured by the subjective assessment. It is therefore worthwhile to include objective gait assessment in fall risk screening.

The determination of linear and angular penetration of the femoral head into the acetabular component as an assessment of wear in total hip replacement: A COMPARISON OF FOUR COMPUTER-ASSISTED METHODS

We have compared four computer-assisted methods to measure penetration of the femoral head into the acetabular component in total hip replacement. These were the Martell Hip Analysis suite 7.14, Rogan HyperOrtho, Rogan View Pro-X and Roman v1.70. The images used for the investigation comprised 24 anteroposterior digital radiographs and 24 conventional acetate radiographs which were scanned to provide digital images. These radiographs were acquired from 24 patients with an uncemented total hip replacement with a follow-up of approximately eight years (mean 8.1; 6.3 to 9.1). Each image was measured twice by two blinded observers. The mean annual rates of penetration of the femoral head measured in the eight-year single image analysis were: Martell, 0.24 (SD 0.19); HyperOrtho, 0.12 (SD 0.08); View Pro-X, 0.12 (SD 0.06); Roman, 0.12 (SD 0.07). In paired analysis of the six-month and eight-year radiographs: Martell, 0.35 (SD 0.22); HyperOrtho, 0.15 (SD 0.13); View Pro-X, 0.11 (SD 0.06); Roman, 0.11 (SD 0.07). The intra- and inter-observer variability for the paired analysis was best for View Pro-X and Roman software, with intraclass correlations of 0.97, 0.87 and 0.96, 0.87, respectively, and worst for HyperOrtho and Martell, with intraclass correlations of 0.46, 0.13 and 0.33, 0.39, respectively. The Roman method proved the most precise and the most easy to use in clinical practice and the software is available free of charge. The Martell method showed the lowest precision, indicating a problem with its edge detection algorithm on digital images.

A comparison of four systems for calibration when templating for total hip replacement with digital radiography

We have investigated the accuracy of the templating of digital radiographs in planning total hip replacement using two common object-based calibration methods with the ball placed laterally (method 1) or medially (method 2) and compared them with two non-object-based methods. The latter comprised the application of a fixed magnification of 121% (method 3) and calculation of magnification based on the object-film-distance (method 4). We studied the post-operative radiographs of 57 patients (19 men, 38 women, mean age 73 years (53 to 89)) using the measured diameter of the prosthetic femoral head and comparing it with the true value. Both object-based methods (1 and 2) produced large errors (mean/maximum: 2.55%/17.4% and 2.04%/6.46%, respectively). Method 3 applying a fixed magnification and method 4 (object-film-distance) produced smaller errors (mean/maximum 1.42%/5.22% and 1.57%/4.24%, respectively; p < 0.01). The latter results were clinically relevant and acceptable when planning was allowed to within one implant size. Object-based calibration (methods 1 and 2) has fundamental problems with the correct placement of the calibration ball. The accuracy of the fixed magnification (method 3) matched that of object-film-distance (method 4) and was the most reliable and efficient calibration method in digital templating.

Inertial sensor motion analysis of gait, sit–stand transfers and step-up transfers: differentiating knee patients from healthy controls

Patients undergoing total knee replacement for end stage knee osteoarthritis (OA) become increasingly younger and more demanding. Consequently, outcome assessment tools need to evolve toward objective performance-based measures. We applied a novel approach toward ambulatory biomechanical assessment of physical function using a single inertial sensor located at the pelvis to derive various motion parameters during activities of daily living. We investigated the potential of a clinically feasible battery of tests to define relevant parameters of physical function. We compared preoperative measures of end stage knee OA patients to healthy subjects. Our results show that measures of time yield the highest discriminative capacity to differentiate between groups. Additionally we found disease-dependent and task-specific alterations of movement for inertial sensor-derived motion parameters with good discriminative capacity. The inertial sensors output quantities seem to capture another clinically relevant dimension of physical function that is supplementary to time. This study demonstrates the potential of inertial sensor-based motion analysis and provides a standardized test feasible for a routine clinical application in the longitudinal follow-up.

Patient-reported outcome measures versus inertial performance-based outcome measures: A prospective study in patients undergoing primary total knee arthroplasty

BACKGROUND Outcome assessment of total knee arthroplasty (TKA) by subjective patient reported outcome measures (PROMs) may not fully capture the functional (dis-)abilities of relevance. Objective performance-based outcome measures could provide distinct information. An ambulant inertial measurement unit (IMU) allows kinematic assessment of physical performance and could potentially be used for routine follow-up. AIM To investigate the responsiveness of IMU measures in patients following TKA and compare outcomes with conventional PROMs. METHODS Patients with end stage knee OA (n=20, m/f=7/13; age=67.4 standard deviation 7.7 years) were measured preoperatively and one year postoperatively. IMU measures were derived during gait, sit-stand transfers and block step-up transfers. PROMs were assessed by using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Knee Society Score (KSS). Responsiveness was calculated by the effect size, correlations were calculated with Spearmans rho correlation coefficient. RESULTS One year after TKA, patients performed significantly better at gait, sit-to-stand transfers and block step-up transfers. Measures of time and kinematic IMU measures demonstrated significant improvements postoperatively for each performance-based test. The largest improvement was found in block step-up transfers (effect size=0.56-1.20). WOMAC function score and KSS function score demonstrated moderate correlations (Spearmans rho=0.45-0.74) with some of the physical performance-based measures pre- and postoperatively. CONCLUSION To characterize the changes in physical function after TKA, PROMs could be supplemented by performance-based measures, assessing function during different activities and allowing kinematic characterization with an ambulant IMU.

Periprosthetic fractures around cementless hydroxyapatite-coated femoral stems

We studied 14 periprosthetic femoral fractures out of a series of 619 hydroxyapatite coated hip implants and compared the outcome to published treatment algorithms using the Vancouver classification. There were five type A fractures, six B1, two B2, and one type B3 fracture. All but one type A fractures were treated conservatively. Compared with the Vancouver classification, we observed a different fracture type in the type B fractures. No fractures at the tip of the stem were seen, as in cemented implants. Three B1 fractures were treated operatively due to fracture displacement, and three were treated conservatively. The B2 and B3 fractures were managed with long, uncemented, revision stems because of a disrupted bone–prosthesis interface. All fractures healed well. This study confirms that the modified algorithm of management of periprosthetic fractures, using the Vancouver classification, is a simple, reproducible, classification system for uncemented prostheses. Conservative treatment is a valid option if the implant is stable whilst surgical intervention is mandatory if the implant is loose.RésuméNous avons étudié 14 fractures fémorales péri prothétiques dans une série de 619 implants de la hanche recouverts d’hydroxyapatite et nous avons comparé le résultat à l’algorithme de traitement utilisant la classification de Vancouver. Il y avait cinq fractures de type A, six de type B1, deux de type B2 et une de type B3. Toutes les fractures de type A, sauf une, ont été traités d’une manière conservatrice. Comparé à la classification de Vancouver nous avons observé un type de fracture différent dans le type B. Aucune fracture à l’extrémité de la tige n’a été vue comme dans les implants cimentés. Trois fractures B1 ont été opérées à cause du déplacement et trois a été traité d’une manière conservatrice. Les fractures B2 et B3 ont été traités avec des tiges longues de révision, sans ciment, à cause d’une interface os-prothèse interrompu. Toutes les fractures ont consolidé. Cette étude confirme que l’algorithme modifié de gestion des fractures péri prothétiques, en utilisant la classification de Vancouver, est un système de classification simple, reproductible, pour les modalités du traitement avec des implants sans ciment. Le traitement conservateur est une option valable en cas d’implant stable, cependant qu’en cas d’implant descellé l’intervention chirurgicale est obligatoire.

Validity of an inertial measurement unit to assess pelvic orientation angles during gait, sit–stand transfers and step-up transfers: Comparison with an optoelectronic motion capture system*

An inertial measurement unit (IMU) allows kinematic evaluation of human motion with fewer operational constraints than a gold standard optoelectronic motion capture (MOCAP) system. The studys aim was to compare IMU and MOCAP measurements of dynamic pelvic orientation angles during different activities of daily life (ADL): gait, sit-to-stand (STS) transfers and block step-up (BS) transfers. A single IMU was attached onto the lower back in seventeen healthy participants (8F/9 M, age 19-31 years; BMI < 25) and optical skin markers were attached onto anatomical pelvic landmarks for MOCAP measurements. Comparisons between IMU and MOCAP by Bland-Altman plots demonstrated that measurements were between 2SD of the absolute difference and Pearsons correlation coefficients were between 0.85 and 0.94. Frontal plane pelvic angle estimations achieved a RMSE in the range of [2.7°-4.5°] and sagittal plane measurements achieved a RMSE in the range of [2.7°-8.9°] which were both lowest in gait. Waveform peak detection times demonstrated ICCs between 0.96 and 1.00. These results are in accordance to other studies comparing IMU and MOCAP measurements with different applications and suggest that an IMU is a valid tool to measure dynamic pelvic angles during various activities of daily life which could be applied to monitor rehabilitation in a wide variety of musculoskeletal disorders.

Clinimetric quality of the new 2011 Knee Society Score: High validity, low completion rate

BACKGROUND The demands of the younger and more active current total knee arthroplasty (TKA) patients are not in line with the current outcome assessments. Therefore, new questionnaires are developed or adjusted, as with the popular 1989 Knee Society Score (KSS). This study is the first to investigate the clinimetric parameters of the patient-reported outcome measurement (PROM) part of the 2011 KSS. METHODS Four-hundred-fifteen primary Dutch TKA patients were scored using the PROM part of the 2011 KSS. The scale is subdivided into an Objective (not evaluated), Satisfaction, Expectation and Function subscales. Clinimetric quality was evaluated by response and completion rate, test-retest reliability (n=29, intraclass correlation coefficient), internal consistency (n=172, Cronbachs alpha), construct validity (Pearsons correlations with 1989 KSS (n=75) and KOOS-PS (n=139)) and responsiveness (n=20, paired-samples t-test, effect sizes and floor and ceiling effects). RESULTS A response rate of 96% and completion rate of 43% were found. Reliability and internal consistency proved excellent with ICCs≥0.79 and Cronbachs alpha≥0.76 for all subscales. Strong correlations were found between the Function subscales of the 2011 KSS and KOOS-PS (r=-0.60 to -0.83). All subscales improved significantly after intervention, with exception of Walking & Standing and Discretionary Activities. 23% reached the maximum score postoperatively in Walking & Standing, indicating a ceiling effect. CONCLUSIONS The 2011 KSS is a reliable, internal consistent, construct valid and responsive questionnaire to assess the outcome of the Dutch TKA patients. Optimizations (e.g. shortening the scale, simplified design) are recommended to increase the disappointing completion rate. CLINICAL RELEVANCE The 2011 KSS is a reliable, internal consistent, construct valid and responsive questionnaire to assess the outcome of the Dutch TKA patients.