Betsy G. Bang

T and B lymphocyte rosetting in undernourished children.

Summary T and B lymphocyte rosetting values were obtained for 18 children with kwashiorkor, marasmus, or nutritional edema. T cell values were subnormal in all malnutrition classes, but were lowest in children with kwashiorkor. Four of five malnourished children who were sensitized with 2,4-dinitrochlorobenzene (DNCB) before refeeding failed to respond to repeated subsequent challenges; five of six children who were sensitized after refeeding responded strongly to the first challenge.

Effect of SO2 on Nasal Secretory Cells

Quantitative histochemical analysis of the secretory cells producing the different types of glycoproteins were examined in the chicken nasal cavity with and without moderate levels of SO2 exposure for 14 days. On the nasal maxillary concha of chickens, the number of acinar gland cells containing glycoproteins was significantly reduced on the 1st, 7th and 14th days of exposure to 11.8 ppm of SO2, but not on the 5th day of exposure. There was no histochemical modification in the intracellular glycoproteins of the acinar cells. The number of goblet cells in the same region increased greatly and showed a change of intracellular glycoproteins from neutral to acid between the 5th and 7th day of exposure.

Sulfanilamide, Sulfapyridine, and Sulfathiazol Therapy of Gonococcal Infection of the Chorio-Allantoic Membrane

Summary Sulfanilamide-resistant and freshly isolated strains of gonococci were tested for their response to sulfanilamide, sodium sulfapyridine, and sodium sulfathiazol on the chorio-allantoic membrane of embryo chicks. The resistant strains retained their resistance in vitro. Sulfanilamide and sulfapyridine were about equally efficient in curing the infection. Sulfathiazol was about 3 times more effective therapeutically than sulfanilamide or sulfapyridine.

Defense mechanisms against viruses in the upper respiratory tract.

Although human volunteers have been used extensively in the study of upper respiratory tract infections, the obvious limitations to such studies have lead to the search for an experimental model which has a nasal anatomic structure reasonably similar to man, i.e., relatively simple turbinates, true sinuses, and a mucociliated, acinar, respiratory epithelium. Among the mammals, only the primates fulfill these needs, for the common laboratory animals such as the mouse, rat or rabbit all have extensively branched and complicated turbinates associated with a highly developed olfactory complex. We have chosen the chick as a model for study because it meets the requisite criteria (Fig. 1) and is a convenient animal for upper respiratory study.

Effect of SO2 on Nasal Secretory Cells in Chicken

1. 11.8ppm SO2曝露によりニワトリ上顎甲介外側の glycoprotein を含む杯細胞数は有意に増加した.2. 11.8ppm SO2曝露により増加した杯細胞は曝露5日目まで主として neutral glycoprotein を産生し, 曝露7日目には acid glycoprotein を産生した.3. 11.8ppm SO2曝露によりニワトリ上顎甲介外側の glycoprotein を含む腺細胞数は有意に減少した.4. 鼻粘膜と気管粘膜上皮の分泌細胞のSO2曝露に対する反応には解離のあることが示唆される.