Betty F Walker

Breast cancer in black African women: a changing situation.

Black African women in rural South Africa have a very low incidence rate of breast cancer, 5-10 per 100,000. The rate, however, is rising in the considerably increasing urban population. During the period 1994 to 1999 in Durban, enquiries revealed an average of 57 urban patients admitted to hospital each year, from a population of about 600,000 African women, indicating an age-adjusted annual incidence rate of 15.1 per 100,000. This incidence rate is very low in comparison with those in developed populations, which range from 40 to 89 per 100,000. In the African patients studied, the mean age on admission was relatively young, 54.1±10.9 years, almost a decade earlier than patients of developed populations. Moreover, the disease was very far advanced; 21.1% were at Stage III and 63.1% at Stage IV. As to exposure to risk factors, African women in general are characterised by certain protective factors. These factors, which closely resemble those of importance in patients in developed populations are, late menarche, early age at birth of first child, high parity (with usually prolonged lactation), and being physically active. However, with ongoing changes in the lifestyle of urban African women, the protective factors are decreasing in their intensity. Changes in these respects have been associated with rises in the disease’s incidence rate. Clearly, because of the late stage of the disease at the time of the patients’ admission to hospital, and hence their poor survival rate, intensive efforts should be made to educate women to seek help at an early stage of their disease. For its avoidance, feasible protective or restraining measures are primarily to adopt a ‘prudent’ lifestyle, in respect of both dietary and non-dietary components. However, the chances of these measures being meaningfully adopted in African urban communities, unfortunately, are negligible. In consequence, further increases in incidence rate would seem inevitable.

Obesity in Black Women in Soweto, South Africa: Minimal Effects on Hypertension, Hyperlipidaemia and Hyperglycaemia:

STUDIES were made on 50 South African urban black obese women aged 25-40 years, with Body Mass Index (BMI) (Kg/m2) of 29.5 or more, and on 50 non-obese women with BMI of 25 or less. In the two groups, mean triceps skinfolds were 25.5mm and 17.8mm, respectively. Hypertension (≥160/95mm Hg) was present in 6 and 4 women (12% and 8%), hypercholesterolaemia (≥5.2mmol/l) in 5 and 3 women (10% and 6%), hypertriglyceridaemia (≥1.8mmol/l) in 5 and 3 (10% and 6%), and hyperglycaemia (≥7.8mmol/l) in 2 and 1 women (4% and 2%). One or more adverse sequelae were present in 11 (22%) obese and in 9 (18%) of non-obese women, proportions not significantly different. Dietarily, mean daily intakes were — Kcals 2273 and 2240, protein 73g and 70g (12.9% and 12.5% energy), fat 65g and 67g (25.7% and 26.9% energy), carbohydrate 349g and 330g (61.4% and 60.5% energy), and dietary fibre, 12g and 13g. In this low socioeconomic and low fat dietary context, obesity in the black women studied was not specifically evocative of deleterious sequelae of obesity.

Some puzzling situations in the onset, occurrence and future of coronary heart disease in developed and developing populations, particularly such in sub-Saharan Africa:

Coronary heart disease (CHD) was rare in developed populations until the early 1900s; this prevailed even among the small segments who were prosperous and who, in measure, had most of the currently recognised risk factors. However, in the 1930s, with improved circumstances from general rises in socio-economic state, there were major increases in the occurrence and mortality rate from the disease, the latter reaching a third of the total mortality in some countries, as in the United Kingdom (UK). Puzzlingly, the inter-population diversity of the increases in CHD has been such that there are as much as five fold differences in CHD mortality rates, as, for example, between Poland and Spain. Within recent years, with appropriate treatments, the mortality rate has halved in some countries, again, as in the UK. However, the incidence rate of the disease has diminished little or hardly at all. Risk factors include a familial component and, nutritionally, over-eating, a high fat intake, relatively low intakes of plant foods, especially of vegetables and fruit and, non-nutritionally, smoking, excessive alcohol consumption and a low level of everyday physical activity. On the one hand, known risk factors, broadly, are considered to be capable of explaining only about half of the variation in the occurrence of the disease. Even at present, known risk factors far from fully explain the epidemiological differences in mortality rates. Yet, on the other hand, there is abundant evidence that in population groups, among whom risk factors are low or have been reduced, CHD incidence and mortality rates are lower. Notwithstanding this knowledge, broadly, there is very little interest in the general public in taking avoiding measures. As to the situation in developing populations, in sub-Saharan Africa, in urban Africans, as in Johannesburg, South Africa, despite considerable westernisation of life style and with rises in risk factors, CHD remains of very low occurrence, the situation thereby resembling, historically, its relatively slow emergence in developed populations. In most eastern countries, mortality rates remain relatively low, as in Russia and Japan. However, in major contrast, in India, rates have risen considerably in urban dwellers. Indeed, in Indian immigrants, as in those in the UK, their rate actually exceeds that in the country’s white population. In brief, much remains to be explained in the epidemiology of the disease.

Variations in Occurrences of Nutrition-Related Diseases in Sub-Saharan Africans in Stages of Transition: What of the Future?

In many Sub-Saharan African populations, in particular urban dwellers, there have been marked rises in the prevalences of obesity in women, hypertension, diabetes, and cerebral vascular disease. Yet there have been only slight rises in coronary heart disease. To learn more of the roles of the various influencing factors in the puzzling situations described, some aspects of the past and present occurrences of these diseases are described and discussed, with comparisons being made with corresponding situations in African Americans, as well as in certain white populations. Despite increases in the knowledge of influencing factors, such fail to explain fully the epidemiologic situations described. As to the future, judging from the experiences of other populations, despite continuing indigence, within the next generation significant rises in coronary heart disease in certain African populations seem to be inevitable. However, in many of those populations, in particular those in the South, the extent of changes, apart from those linked with level of socioeconomic state, will be strongly affected by the rising epidemic of human immunodeficiency virus and acquired immunodeficiency syndrome.

Is breast cancer avoidable? Could dietary changes help?

In the US, the life time odds of developing breast cancer has reached one in eight, with an incidence rate of 85 per 100,000 world population. The rate is half or less in women in some Mediterranean countries. At the extreme are rural African women whose rate is approximately 5-10 per 100,000. In African, compared with White women, protective factors include (1) reproductive behaviour, namely, slower growth before and after puberty, later age at menarche, high teenage pregnancy, high parity and long periods of lactation and amenorrhoea and (2) a diet of relatively low energy intake and of low-fat and high-fibre contents. In the Mediterranean setting, major dietary protective factors include a relatively low intake of saturated fat and high intakes of monounsaturated fat and of vegetables and fruit. Among White women, a reversion to protective reproductive behaviour is out of the question. Only in respect of diet, could significant avoiding action be taken. Adoption of an African type diet is wholly impracticable. Moreover, even conformation to a former Mediterranean diet, which is already changing, would be difficult, requiring reorientation of fat composition and large rises in intakes of vegetable and fruit. However, with resolution, were such changes made, at least by the very vulnerable, they would help, additionally, to protect against other diet-related cancers, especially colon cancer and against coronary heart disease.

A catastrophe in the 21st century: the public health situation in South Africa following HIV/AIDS

During the early 1900s, African populations in South Africa were subject to very widespread infections which especially affected the young. This resulted in high mortality rates and a low life expectancy of 20-25 years. By the mid-century, mortality rates from infections had decreased considerably. Moreover, the occurrences of non-communicable diseases, even in urban areas, remained very low. In the 1970s, the proportion of Africans aged 50 or over that reached 70 years was 38.5%, higher than that in the juxtaposed white population, which was 35.5%. And by 1985, the life expectancy of Africans reached 61 years for males and 63 years for females, probably the highest in sub-Saharan African populations. Since then, however, the African continent has been devastated by the AIDS epidemic. In 2001, HIV was responsible for the death of a third of the African population in South Africa, but even higher proportions prevailed in Botswana and in Tanzania. The calamitous advent of the HIV infection has caused major falls in life expectancy, in the case of Africans in South Africa reducing this to just 43 years. With little hope of meaningful changes occurring in sexual habits or of an early vaccine becoming available, the infectionís high morbidity/mortality burden is likely to continue.

Growth of South African Indian schoolchildren in different social classes.

The height and weight of 4594 Indian schoolchildren aged 6 to 17 years, in Durban, South Africa, were measured at schools selected by inspectors as representative of upper, intermediate, and lower socio-economic populations. Significant superiority, anthropometrically, prevailed at all ages in upper compared with lower or poor-class children, but tended to lessen at 17 years. In the affluent group, in the age period studied the proportions under the 5th percentile of USA NCHS reference values were--concerning height-for-age 4.7% to 22.0% of boys and 5.0% to 20.7% of girls; and concerning weight-for-age, 20.3% to 45.0% of boys and 9.3% to 37.7% of girls. In the affluent group, at full growth at 17 years, means of height and weight were highly significantly lower, namely, roughly by 7cm and 10kg, compared with respective mean values given in USA reference values. Hence, in Indian schoolchildren a genetic factor, and not dietary inadequacy, appears primarily responsible for both slower post-pubertal growth and lower ultimate height attainment.

Moderate to mild malnutrition in African children of 10-12 years : rôles of dietary and non-dietary factors

In all Third World populations, among preschool and schoolchildren, low weight- and height-for-age, i.e. below the 5th centile of US NCHS reference standards, are common, affecting 10-50%. Orthodoxly, shortfalls are attributed largely to insufficiency of food. In an attempt to throw more light on the situation regarding African schoolchildren, studies have been made on series of pupils, aged 10-12 years, at three rural schools in North West Province, South Africa. Of 396 pupils, 126 (31.8%) were below, and 270 (68.2%) above the 5th centile. Enquiries were made on each pupils diet and meal pattern, their class position and games aptitude, and, regarding home characteristics, their family size, Parent(s) working, and the latters interest in education. With minor exceptions, no significant differences in odds ratios were found between respective groups below and above the 5th centile. Evidently, there are multiple influencing factors. Hence, among children of school-age, there must be caution against overblaming undernutrition, and of overrating the health disadvantages from mild to moderate malnutrition. For definition clarification, long-term observations are necessary.

The benefits of iron supplementation and prophylaxis in africa

Iron deficiency is reported to be the commonest nutritional deficiency the world over. An examination of the literature indicates numerous perplexities regarding iron intake and iron stores, the epidemiology of deficient iron stores, the stigmata of deficiency, supplementation practices, dangers from excessive intake, and tangible benefits from iron supplements and prophylaxis. In impoverished Africa, there is intense competition for the limited health dollar. Hence, there must be clarification of the uncertainties depicted, and a more precise appreciation of the benefits derivable from iron supplementation, compared with those from other nutritional, and non-nutritional, interventions.

'One million people die on the world's roads every year'--are there any hopes of alleviation?

1suggests that nearly 1.2 million people die on the world’s roads each year. This number is expected to rise by 65% over the next two decades, 1 with most such deaths occurring in the developing world. Other data indicate that Britain now has the safest roads in the world. 2 Numerically, 5.9 people out of every 100 000 inhabitants are killed on British roads each year, compared with 11.0 in the European Union as a whole, 8.2 in Japan, and 15.2 in the USA. This figure rises to 42.2 in El Salvadore, a developing country. In India, with a population of about 900 million, 217 000 people perished in road accidents in 1998. South Africa has a population of about 45 million people — in the year 2000 there were half a million deaths, of which 18 000 (3.6%) were caused by road accidents. 3