Beverly S. Reigle

Trastuzumab and Doxorubicin-Related Cardiotoxicity and the Cardioprotective Role of Exercise

Women diagnosed with breast cancer typically undergo a multimodal approach to treating their disease. The treatments used often result in sequelae such as fatigue, hair loss, nausea and vomiting, and functional impairment. Many of these sequelae can be controlled or eliminated with pharmacological, physical, or social interventions. However, 2 effective cytotoxic agents, doxorubicin and trastuzumab, are associated with a potentially life-threatening sequela, cardiotoxicity. Currently, these agents are dosage and duration limited to circumvent cardiac damage. Exercise prior to and during the administration of these agents is emerging as a possible cardioprotective intervention based on the findings of animal model studies. Incorporating exercise into the breast cancer treatment trajectory may eliminate the dosage and duration restrictions of these antineoplastic agents and ultimately affect survival and quality of life. The authors present the pharmacological mechanism for each agent and the exciting results of animal model studies that lay the groundwork for future clinical trials.

Evidence-based practice and the road to Magnet status.

Conducting research and using evidence-based practice play a major role in achieving Magnet status, the sought-after recognition awarded by the American Nurses Credentialing Center to healthcare institutions that exhibit nursing excellence. The authors present a synopsis of a conference sponsored by a Sigma Theta Tau International consortium in which a panel of nurse leaders distinguishes between research and evidence-based practice and discusses strategies to achieve both in the journey to Magnet status.

Breast Cancer and the Role of Exercise in Women

Cancer of the breast is a significant health problem for women from the time of diagnosis through the treatment and survivorship trajectory. The disease and treatments are an assault to a womans body, resulting in sequelae that can be debilitating. Although women diagnosed with breast cancer are living longer, concerns about functional limitations, recurrence, and survival remain paramount. Physical activity and exercise are preventative and rehabilitative measures that can be employed at various points along the breast cancer trajectory. Current research supports the beneficial role that physical activity and exercise play in reducing the risk for developing breast cancer and preventing or attenuating disease and treatment-related impairments.

Sepsis and treatment-induced immunosuppression in the patient with cancer

Treatment for cancer is frequently an assault to the immune system. The immunosuppression that results significantly increases the patients risk for infection. In this patient population, infection can quickly progress to sepsis, septic shock, and death. A high index of suspicion during nursing assessments is a critical strategy in early identification of infections. In addition, judicious adherence to infection control measures, appropriate use of prophylactic agents, and immediate employment of broad-spectrum antibiotics that are empirically based are essential strategies to maximize the patients likelihood for survival.

Women's Rehabilitation Experiences Following Breast Cancer Surgery

Background Breast cancer survivors represent 23% of the 15.5 million cancer survivors in the United States. Treatment-related morbidities such as adhesive capsulitis and lymphedema impact functional ability and quality of life. Postoperative exercises have been recommended for years. However, few studies exist that describe the postoperative rehabilitation experience of breast cancer survivors. Purpose The purpose of the study was to examine the rehabilitation experiences of women following breast cancer surgery. Methodology The study used a descriptive–correlational design. A convenience sample of 594 breast cancer survivors completed and returned a mailed questionnaire. Findings Results indicated that 61% reported that postoperative exercises were prescribed. Forty-eight percent reported performing the exercises as instructed. Performing exercises as instructed was significantly associated with increased functional ability (p < .0001). Conclusion Breast cancer survivors who perform postoperative rehabilitation exercises as instructed may improve functional ability. Clinical Implication Rehabilitation nurses can have an instrumental role in the postoperative rehabilitation care of this population.