Bhim Chandra Maiti

PROTECTIVE EFFECT OF LEAF EXTRACT OF FICUS HISPIDA LINN AGAINST PARACETAMOL-INDUCED HEPATOTOXICITY IN RATS

The methanol extract of the leaves of Ficus hispida Linn. (Moraceae) was evaluated for hepatoprotective activity in rats by inducing acute liver damage by paracetamol (750 mg/kg, p.o.). The extract at an oral dose of 400 mg/kg exhibited a significant protective effect by lowering the serum levels of transaminase (SGOT and SGPT), bilirubin and alkaline phosphatase (ALP). These biochemical observations were supplemented by histopathological examination of liver sections. The activity of extract was also comparable to that of Liv‐52 a known hepatoprotective formulation. Copyright

Neuropharmacological Activity of Xanthium strumarium Linn. Extract

ABSTRACT Rodents treated with extract from Xanthium strumarium Linn. (Compositae) exhibited alterations in general behavior patterns, reduction in spontaneous motility, prolongation of pentobarbitone-induced sleep, suppression of exploratory behavior patterns, and avoidance response. The observations suggested Xanthium strumarium had significant depressant action of the central nervous system.

Effect of Berberis tinctoria leaf (Berberidaceae) extract on antidiabetic, antihyperlipidemic and antioxidant status in streptozotocin induced diabetes in rats

The present study was carried out to investigate the antidiabetic and antioxidant effect of methanolic extract of Berberis tinctoria leaves (MEBT), in streptozotocin induced diabetic rats. Oral administration of MEBT extract (150 mg/kg and 300 mg/kg) for a period of 14 days. Blood glucose levels, body weight food and liquid intake were measured on every day over a period of 14 days. In diabetic rats, MEBT at the dose of 150 mg/kg and 300 mg/kg body weight resulted in significant reduction in blood glucose levels. The study was further investigated to determine antioxidant and antihyperlipidemic potential of MEBT in streptozotocin (STZ) induced diabetic rats. These results suggest that the MEBT possess antidiabetic activity and is able to ameliorate biochemical damages in STZ induced diabetic rats and the results were found to be in a dose dependent manner.