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Featured researches published by Bibi Gram.


BMC Public Health | 2010

Worksite interventions for preventing physical deterioration among employees in job-groups with high physical work demands: Background, design and conceptual model of FINALE

Andreas Holtermann; Marie Birk Jørgensen; Bibi Gram; Jeanette Reffstrup Christensen; Anne Faber; Kristian Overgaard; John Ektor-Andersen; Ole Steen Mortensen; Gisela Sjøgaard; Karen Søgaard

BackgroundA mismatch between individual physical capacities and physical work demands enhance the risk for musculoskeletal disorders, poor work ability and sickness absence, termed physical deterioration. However, effective intervention strategies for preventing physical deterioration in job groups with high physical demands remains to be established. This paper describes the background, design and conceptual model of the FINALE programme, a framework for health promoting interventions at 4 Danish job groups (i.e. cleaners, health-care workers, construction workers and industrial workers) characterized by high physical work demands, musculoskeletal disorders, poor work ability and sickness absence.Methods/DesignA novel approach of the FINALE programme is that the interventions, i.e. 3 randomized controlled trials (RCT) and 1 exploratory case-control study are tailored to the physical work demands, physical capacities and health profile of workers in each job-group. The RCT among cleaners, characterized by repetitive work tasks and musculoskeletal disorders, aims at making the cleaners less susceptible to musculoskeletal disorders by physical coordination training or cognitive behavioral theory based training (CBTr). Because health-care workers are reported to have high prevalence of overweight and heavy lifts, the aim of the RCT is long-term weight-loss by combined physical exercise training, CBTr and diet. Construction work, characterized by heavy lifting, pushing and pulling, the RCT aims at improving physical capacity and promoting musculoskeletal and cardiovascular health. At the industrial work-place characterized by repetitive work tasks, the intervention aims at reducing physical exertion and musculoskeletal disorders by combined physical exercise training, CBTr and participatory ergonomics. The overall aim of the FINALE programme is to improve the safety margin between individual resources (i.e. physical capacities, and cognitive and behavioral skills) and physical work demands, and thereby reduce the physical deterioration in a long term perspective by interventions tailored for each respective job-group.DiscussionThe FINALE programme has the potential to provide evidence-based knowledge of significant importance for public health policy and health promotion strategies for employees at high risk for physical deterioration.Trial registrationsISRCTN96241850, NCT01015716 and NCT01007669


Clinical Journal of Sport Medicine | 2010

Effects of nordic walking and exercise in type 2 diabetes mellitus: a randomized controlled trial.

Bibi Gram; Robin Christensen; Christian Christiansen; Jeppe Gram

Objective: Both Nordic walking and Exercise on Prescription have potential as elements in the management of type 2 diabetes mellitus. These programs are recommended, but their effectiveness has not yet been established. The aim was to evaluate the efficacy of these 2 interventions compared with standard information on physical activity. Design: Single-blinded, randomized, controlled intervention study. Setting: Sixty-eight patients (37 men and 31 women) were randomized into 3 groups: Nordic walking (NW; n = 22), Exercise on Prescription (EP; n = 24), and control (CG; n = 22). Patients: Patients were recruited from a diabetes outpatient clinic and via newspaper advertisement. Interventions: Consisted of a 4-month intervention period followed by an 8-month follow-up, during which the participants were recommended to train on their own. Main Outcome Measures: HbA1c. Results: There was no difference in HbA1c when comparing the intervention groups relative to the control group: ΔNW = −0.4% [95% confidence intervals (CI), −0.9% to 0.1%] and ΔEP = −0.2% (95% CI, −0.6% to 0.2%) after 4 months; ΔNW = 0.0% (95% CI, −0.6% to 0.5%) and ΔEP = 0.3% (95% CI, −0.3% to 0.9%) after 12 months. However, fat mass assessed by dual energy X-ray absorptiometry (DXA) decreased significantly in the NW group after 4 months [−1.0 kg (95% CI, −1.7 to 0.1)] and after 12 months in both NW [−1.8 kg (95% CI, −3.2 to −0.4)] and EP [−1.5 kg (95% CI, −2.9 to −0.05)] groups. No significant changes in other variables. Conclusions: Four-month exercise programs at moderate intensity of either Nordic walking or Exercise on Prescription did not significantly improve HbA1c in patients with type 2 diabetes either at the end of the program or at the follow-up.


British Journal of Sports Medicine | 2012

Influence of frequency and duration of strength training for effective management of neck and shoulder pain: a randomised controlled trial

Christoffer H. Andersen; Lars L. Andersen; Bibi Gram; Mogens Theisen Pedersen; Ole Steen Mortensen; Mette K. Zebis; Gisela Sjøgaard

Background Specific strength training can reduce neck and shoulder pain in office workers, but the optimal combination of exercise frequency and duration remains unknown. This study investigates how one weekly hour of strength training for the neck and shoulder muscles is most effectively distributed. Methods A total of 447 office workers with and without neck and/or shoulder pain were randomly allocated at the cluster-level to one of four groups; 1×60 (1WS), 3×20 (3WS) or 9×7 (9WS) min a week of supervised high-intensity strength training for 20 weeks, or to a reference group without training (REF). Primary outcome was self-reported neck and shoulder pain (scale 0–9) and secondary outcome work disability (Disability in Arms, Shoulders and Hands (DASH)). Results The intention-to-treat analysis showed reduced neck and right shoulder pain in the training groups after 20 weeks compared with REF. Among those with pain ≥3 at baseline (n=256), all three training groups achieved significant reduction in neck pain compared with REF (p<0.01). From a baseline pain rating of 3.2 (SD 2.3) in the neck among neck cases, 1WS experienced a reduction of 1.14 (95% CI 0.17 to 2.10), 3WS 1.88 (0.90 to 2.87) and 9WS 1.35 (0.24 to 2.46) which is considered clinically significant. DASH was reduced in 1WS and 3WS only. Conclusion One hour of specific strength training effectively reduced neck and shoulder pain in office workers. Although the three contrasting training groups showed no statistical differences in neck pain reduction, only 1WS and 3WS reduced DASH. This study suggests some flexibility regarding time-wise distribution when implementing specific strength training at the workplace.


Scandinavian Journal of Work, Environment & Health | 2012

Effect of individualized worksite exercise training on aerobic capacity and muscle strength among construction workers--a randomized controlled intervention study.

Bibi Gram; Andreas Holtermann; Karen Søgaard; Gisela Sjøgaard

OBJECTIVES The combination of high physical work demands and low physical capacity has been shown to increase the risk for cardiovascular disease and musculoskeletal disorders. The aim of this study was to assess the physical capacity of construction workers and evaluate the effect of individually tailored exercise programs on their physical fitness and muscular capacity. METHOD The study was a randomized controlled trial of male constructions workers allocated to either an exercise or control group. The intervention lasted 12 weeks, and the exercise group trained 3 x 20 minutes a week. The participants completed health checks before and after the intervention period. Data from the first health check were used to tailor the exercise in the interventions. RESULTS At baseline, participants had maximal oxygen consumption (VO(2max)) of 2.9 [standard deviation (SD) 0.7] l/min and body mass index (BMI) of 28.3 (SD 4.7). Compared to representative data on employees in Denmark (N=78), this study population (N=67) had significantly lower relative aerobic capacity [difference in z-score -1.13 , standard error (SE) 0.1, P<0.001] and higher BMI [difference in z-score 1.10, SE 0.2, P<0.001] at baseline. With respect to the intervention, group x time analyses showed a significant difference in estimated change in VO(2max)of 0.4 l/min for the exercise group and 0.0 l/min for the control group (P<0.001). Body mass and other general health measures remained unchanged. CONCLUSION Training for 20 minutes, 3 times a week significantly increased VO(2max)with a clinically relevant magnitude regarding risk of cardiometabolic disorders. This study demonstrates a good effectiveness for integrating short exercise bouts into organizational routines among constructions workers.


Journal of Occupational and Environmental Medicine | 2012

Does an exercise intervention improving aerobic capacity among construction workers also improve musculoskeletal pain, work ability, productivity, perceived physical exertion, and sick leave? : a randomized controlled trial

Bibi Gram; Andreas Holtermann; Ute Bültmann; Gisela Sjøgaard; Karen Søgaard

Objective:To investigate whether an exercise intervention shown to increase aerobic capacity, would also lead to less musculoskeletal pain; improved work ability, productivity, and perceived physical exertion; and less sick leave. Methods:Sixty-seven construction workers were randomized into an exercise group training 3 × 20 minutes per week and a control group. Questionnaires and text messages were completed before and after the 12-week intervention. Results:No significant changes were found in musculoskeletal pain, work ability, productivity, perceived physical exertion, and sick leave with the intervention. Questionnaires and text messages provided similar results of pain and work ability. Conclusions:Although the intervention improved aerobic capacity, it was not successful in improving musculoskeletal pain and other work-related factors. A detectable improvement presumably requires a more multifaceted intervention, larger sample size, or longer follow-up. Text messages may be a convenient data-collection method in future studies.


BioMed Research International | 2014

Effect of Training Supervision on Effectiveness of Strength Training for Reducing Neck/Shoulder Pain and Headache in Office Workers: Cluster Randomized Controlled Trial

Bibi Gram; Christoffer H. Andersen; Mette K. Zebis; Thomas Viskum Gjelstrup Bredahl; Mogens Theisen Pedersen; Ole Steen Mortensen; Rigmor Jensen; Lars L. Andersen; Gisela Sjøgaard

Objective. To investigate the effect of workplace neck/shoulder strength training with and without regular supervision on neck/shoulder pain and headache among office workers. Method. A 20-week cluster randomized controlled trial among 351 office workers was randomized into three groups: two training groups with the same total amount of planned exercises three times per week (1) with supervision (3WS) throughout the intervention period, (2) with minimal supervision (3MS) only initially, and (3) a reference group (REF). Main outcome is self-reported pain intensity in neck and shoulder (scale 0–9) and headache (scale 0–10). Results. Intention-to-treat analyses showed a significant decrease in neck pain intensity the last 7 days in 3MS compared with REF: −0.5 ± 0.2 (P < 0.02) and a tendency for 3WS versus REF: −0.4 ± 0.2 (P < 0.07). Intensity of headache the last month decreased in both training groups: 3WS versus REF: −1.1 ± 0.2 (P < 0.001) and 3MS versus REF: −1.1 ± 0.2 (P < 0.001). Additionally, days of headache decreased 1.0 ± 0.5 in 3WS and 1.3 ± 0.5 in 3MS versus REF. There were no differences between the two training groups for any of the variables. Conclusion. Neck/shoulder training at the workplace reduced neck pain and headache among office workers independently of the extent of supervision. This finding has important practical implications for future workplace interventions.


Diabetes Care | 2013

Combined heart rate- and accelerometer-assessed physical activity energy expenditure and associations with glucose homeostasis markers in a population at high risk of developing diabetes: the ADDITION-PRO study.

Anne-Louise Smidt Hansen; Bendix Carstensen; Jørn Wulff Helge; Nanna B. Johansen; Bibi Gram; Jens Sandahl Christiansen; Soren Brage; Torsten Lauritzen; Marit E. Jørgensen; Mette Aadahl; Daniel R. Witte

OBJECTIVE Regular physical activity (PA) reduces the risk of developing type 2 diabetes, and different subtypes of dysglycemia have shown different associations with PA. To better understand the associations of PA and glucose homeostasis, we examined the association of objectively measured PA energy expenditure (PAEE) with detailed measures of glucose homeostasis. RESEARCH DESIGN AND METHODS In 1,531 men and women, with low to high risk of developing type 2 diabetes, we measured 7 days of PAEE using a combined accelerometry and heart rate monitor (ActiHeart). Measures and indices of glucose homeostasis were derived from a 3-point oral glucose tolerance test in addition to measures of long-term glycemia (glycated hemoglobin A1c and advanced glycation end products). Associations of PAEE with glucose homeostasis markers were examined using linear regression models. RESULTS Median age (IQR) was 66.6 years (62.1–71.6) (54% men) with a median ActiHeart wear time of 6.9 days (6.0–7.1) and PAEE level of 33.0 kJ/kg/day (23.5–46.1). In fully adjusted models, we found higher levels of PAEE to be positively associated with insulin sensitivity and negatively with insulin 2 h after glucose load (P < 0.05). CONCLUSIONS Even in an elderly population with low levels of PA, we found higher objectively measured PAEE levels to be associated with a more beneficial glucose metabolic profile. Although our findings are cross-sectional, they indicate that even without high-intensity exercise, increasing the overall level of PAEE slightly in an entire population at risk for developing type 2 diabetes may be a realistic and worthwhile goal to reach in order to achieve beneficial effect in terms of glucose metabolism.


Manual Therapy | 2016

Does a combination of physical training, specific exercises and pain education improve health-related quality of life in patients with chronic neck pain? A randomised control trial with a 4-month follow up

Inge Ris; Karen Søgaard; Bibi Gram; Karina Agerbo; Eleanor Boyle; Birgit Juul-Kristensen

AIM To investigate the effect of combining pain education, specific exercises and graded physical activity training (exercise) compared with pain education alone (control) on physical health-related quality of life (HR-QoL) in chronic neck pain patients. METHODS A multicentre randomised controlled trial of 200 neck pain patients receiving pain education. The exercise group received additional exercises for neck/shoulder, balance and oculomotor function, plus graded physical activity training. Patient-reported outcome measures (Short Form-36 Physical and Mental component summary scores, EuroQol-5D, Beck Depression Inventory-II, Neck Disability Index, Pain Bothersomeness, Patient-Specific Functioning Scale, Tampa Scale of Kinesiophobia, Global Perceived Effect) and clinical tests (Aastrand Physical Fitness, cervical Range of Motion, Pressure Pain Threshold at infraspinatus, tibialis anterior and cervical spine, Cranio-cervical Flexion, Cervical Extension muscle function, and oculomotion) were recorded at baseline and after 4 months. RESULTS The exercise group showed statistically significant improvement in physical HR-QoL, mental HR-QoL, depression, cervical pressure pain threshold, cervical extension movement, muscle function, and oculomotion. Per protocol analyses confirmed these results with additional significant improvements in the exercise group compared with controls. CONCLUSIONS This multimodal intervention may be an effective intervention for chronic neck pain patients. TRIAL REGISTRATION The trial was registered on www.ClinicalTrials.govNCT01431261 and at the Regional Scientific Ethics Committee of Southern Denmark S-20100069.


Obesity | 2018

Supervised Physical Training Improves Weight Loss After Roux-en-Y Gastric Bypass Surgery: A Randomized Controlled Trial: Exercise Improves Weight Loss after RYGB

Lene Hymøller Mundbjerg; Charlotte Røn Stolberg; Stefano Cecere; Else-Marie Bladbjerg; Peter Funch-Jensen; Bibi Gram; Claus Bogh Juhl

Bariatric surgery results in significant weight loss and reduces cardiovascular morbidity. However, a large variation in postsurgery weight loss is seen. Physical activity promotes weight loss in nonsurgically treated subjects with obesity. The aim of this study was to investigate the effects of 6 months of supervised physical training following Roux‐en‐Y gastric bypass surgery (RYGB) on body weight and cardiovascular risk markers.


Surgery for Obesity and Related Diseases | 2018

Effects of gastric bypass followed by a randomized study of physical training on markers of coagulation activation, fibrin clot properties, and fibrinolysis

Charlotte Røn Stolberg; Lene Hymøller Mundbjerg; Peter Funch-Jensen; Bibi Gram; Claus Bogh Juhl; Else-Marie Bladbjerg

BACKGROUND The risk of cardiovascular disease is reduced by bariatric surgery, but it is unknown if exercise after bariatric surgery reduces this risk even further. OBJECTIVE To investigate if Roux-en-Y-gastric bypass (RYGB) and supervised physical training after RYGB improve cardiovascular disease risk markers within coagulation activation, fibrin clot properties, and fibrinolysis. SETTING Bariatric center, Hospital of Southwest Jutland, Denmark. METHODS Sixty obese patients underwent RYGB and 6 months after RYGB were randomized to 26 weeks of physical training or a control group. Biomarkers within coagulation activation, fibrin clot properties, and fibrinolysis were measured presurgery, and 6, 12, and 24 months postsurgery. RESULTS Six months after RYGB, the endogenous thrombin potential decreased from 1744 (1603-2003) to 1416 (1276-1582) nM × min (P<.001). Alterations in fibrin clot properties resulted in an increased clot lysis from 23.8% (16.1%-38.9%) to 40.3% (28.5%-59.35; P<.0001). Furthermore, fibrinogen was reduced from 12.6 (11.1-14.7) to 11.5 (9.90-13.3) µM (P<.001), and plasminogen activator inhibitor antigen was reduced from 40.5 (28.4-49.4) to 24.4 (15.4-32.7) ng/mL (P<.0001). Physical training after RYGB increased fibrinolytic activity from 58.0 (36.0-75.5) to 88.0 (66.0-132.0) IU/mL compared with 52.5 (30.0-80.0) to 64.0 (49.0-100.0) IU/mL in controls (P<.01) and reduced plasminogen activator inhibitor antigen from 23.5 (16.7-35.4) to 18.1 (14.3-25.4) ng/mL compared with 24.4 (13.9-28.7) to 24.2 (14.1-29.6) ng/mL in controls (P<.05). No effects of physical training were observed on markers of coagulation activation and fibrin clot properties. CONCLUSION We observed favorable long-term reductions in markers of thrombin generation, improved fibrin clot properties, and increases in fibrinolysis after RYGB. Supervised physical training after RYGB further increased fibrinolysis.

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Claus Bogh Juhl

University of Southern Denmark

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Else-Marie Bladbjerg

University of Southern Denmark

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Gisela Sjøgaard

University of Southern Denmark

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Karen Søgaard

University of Southern Denmark

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Andreas Holtermann

University of Southern Denmark

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Louise Schlosser Mose

University of Southern Denmark

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Rigmor Jensen

University of Copenhagen

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Susanne S. Pedersen

University of Southern Denmark

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