Bing-Hua Jiao
Second Military Medical University
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Bing-Hua Jiao.
Natural Product Research | 2008
Xiao-Ling Lu; Q. Zh. Xu; Yun-Heng Shen; Xiao-Yu Liu; Bing-Hua Jiao; Wen Zhang; Kai Ni
A new 24-membered ring lactone, macrolactin S, was isolated from a culture broth of marine Bacillus sp. and its structure was established by various spectral analyses. Macrolactin S is the first macrolactin hydroxylated at C-12. Besides, the known compounds macrolactin A and macrolactin B were also isolated, which were elucidated on the basis of spectral data analyses and literature data comparison. They exhibited antibacterial activity against E. coli and S. aureus.
Chemistry & Biodiversity | 2008
Xiao-Ling Lu; Qiangzhi Xu; Xiao-Yu Liu; Xin Cao; Kunyi Ni; Bing-Hua Jiao
The increasing demands for new lead compounds in pharmaceutical and agrochemical industries have driven scientists to search for new bioactive natural products. Marine microorganisms are rich sources of novel, bioactive secondary metabolites, and have attracted much attention of chemists, pharmacologists, and molecular biologists. This mini‐review mainly focuses on macrolactins, a group of 24‐membered lactone marine natural products, aiming at giving an overview on their sources, structures, biological activities, as well as their potential medical applications.
Mini-reviews in Medicinal Chemistry | 2013
Jing-Tang Liu; Xiao-Ling Lu; Xiao-Yu Liu; Yun Gao; Bo Hu; Bing-Hua Jiao; Heng Zheng
Polar regions are remote and challenging areas on the earth. In view of the unique environment and the severe competition in polar regions, its considered that the ecological system might be the producer of new compounds with diversity biological activities. This review is an attempt to consolidate the studies about 97 natural products isolated from Antarctic and Arctic organisms including microbes, algae, sponges, bryozoans, and tunicates and so on published in the recent years. The emphasis is mainly about the new compounds, source organisms and biological activities, which signifies the immense competence of Antarctic and Arctic organisms as bioactive natural products producers.
The Journal of Antibiotics | 2014
Xiao-Ling Lu; Jing-Tang Liu; Xiao-Yu Liu; Yun Gao; Jian-Peng Zhang; Bing-Hua Jiao; Heng Zheng
Two new diterpenes, libertellenone G(1) and libertellenone H(2) were isolated from the fungus Eutypella sp. D-1 isolated from the soil of high latitude of Arctic, together with two known pimarane diterpenes (3–4). The structures of 1 and 2 were elucidated from spectroscopic data (nuclear magnetic resonance, mass spectrometry and infrared). These compounds were evaluated for cytotoxic activity against seven human tumor cell lines. Compound 2 showed a range of cytotoxicity between 3.31 and 44.1 μM. Compound 1 exhibited antibacterial activity against Escherichia coli, Bacillus subtilis and Staphylococcus aureus.
Current Medicinal Chemistry | 2010
Xiao-Ling Lu; Xin Cao; Xiao-Yu Liu; Bing-Hua Jiao
Src family tyrosine kinases (SFKs) play key roles in regulating signal transduction in cellular processes. However, hyper-activated SFKs lead to uncontrolled cell proliferation and cancers. For both Src SH2 and SH3 domains involve in the regulation of tumorigenesis signal pathways, the SH2 and SH3 inhibition strategies are expected to block the protein-protein interactions between SFKs and their corporation proteins to abolish the signal transduction. Many inhibitors of SH2 and SH3 domain have been identified. Herein, some predominant examples of these inhibitors are reviewed.
Chemistry & Biodiversity | 2010
Hua Han; Qiangzhi Xu; Yanghua Yi; Wei Gong; Bing-Hua Jiao
Two new disulfated triterpene glycosides, pentactasides B and C (1 and 2, resp.), were isolated from the sea cucumber Pentacta quadrangularis collected from the South China Sea. Their structures were elucidated by extensive spectral analysis (2D‐NMR and MS) and chemical methods. The compounds 1 and 2 possess the same tetrasaccharide moieties with two sulfated groups, but are different in the side chains of the triterpene aglycone. Pentactasides B and C (1 and 2, resp.) showed significant cytotoxicities (IC50 0.09–2.30 μM) against different human tumor cell lines.
Mini-reviews in Medicinal Chemistry | 2010
Xiao-Ling Lu; Xin Cao; Xiao-Yu Liu; Bing-Hua Jiao
This review covers natural products isolated from marine microorganisms including bacteria, fungi and actinomycetes published in the recent years. The emphasis is mainly about new compounds, together with their anti-bacterial activities, source organisms and country of origin, biosynthetic studies as well as the mechanisms involved in their anti-bacterial activities.
Chemistry & Biodiversity | 2014
Jing-Tang Liu; Bo Hu; Yun Gao; Jian-Peng Zhang; Bing-Hua Jiao; Xiao-Ling Lu; Xiao-Yu Liu
Three new cytochalasins Z24, Z25, Z26 (1–3, resp.) and one known compound, scoparasin B (4), were isolated from the fungus Eutypella sp. D‐1 isolated from the soil of high latitude of the Arctic. The structures of 1–3 were elucidated from spectroscopic data (NMR, MS). These compounds were evaluated for cytotoxic activities against several human tumor cell lines. Among them, compound 1 exhibited moderate cytotoxicity toward human breast cancer MCF‐7 cell line with IC50 of 9.33 μM.
Chemistry of Natural Compounds | 2009
Xiao-Ling Lu; Yun-Heng Shen; Yuping Zhu; Qiangzhi Xu; Xiao-Yu Liu; Kunyi Ni; Xin Cao; Wei-Dong Zhang; Bing-Hua Jiao
Marine organisms, especially marine microorganisms, have been proven to be a rich source of diverse arrays of bioactive metabolites with great potential for pharmaceutical and medical applications. Marine Bacillus subtilis is a common strain species, which usually produces cyclopeptide, macrolide, indole derivatives, etc. In the course of further studies, 10 diketopiperazines: cyclo(Leu-Ile) (1) [1], cyclo(Leu-Leu) (2) [2], cyclo(Trp-Pro) (3) [3], cyclo(Leu-Pro) (4) [4, 5], cyclo(Phe-Ala) (5) [6], cyclo(PheTyr) (6) [2], cyclo(benzyl-Gly) (7) [7], cyclo(Val-Val) (8) [8], cyclo(Gla-Tyr) (9) [9], cyclo(Ala-Tyr) (10) [10], 1-(4-hydroxyphenyl)ethanone (11) [11], and macrolactin B (12) [12] have been isolated from the marine Bacillus subtilis. Among them, compound 7 is a new natural product. All the compounds have not been reported before from this species. The strain 201721 has been derived from sea sediment of East Sea of China. It was isolated on F1 medium [Glucose (6 g), peptone (5 g), and yeast extract (1 g) were dissolved in artifical seawater (1L)] with incubation for 4 days at 28°C. Due to its chemical and morphological features as well as the 16S rDNA (GenBank accession number EF417872), the strain can be identified as the genus Bacillus sp. Chemistry of Natural Compounds, Vol. 45, No. 2, 2009
Mini-reviews in Medicinal Chemistry | 2014
Xiao-Hui Shang; Xiao-Yu Liu; Jian-Peng Zhang; Yun Gao; Bing-Hua Jiao; Heng Zheng; Xiao-Ling Lu
The sea urchin is an ancient, common, seafloor-dwelling marine invertebrate that belongs to the phylum Echinodermata. There are multiple species of sea urchin with resources that are widely distributed in China, where they were used in ancient times as Traditional Chinese Medicine for treating a variety of diseases. At present, it is known that the shell, spine and gonad of the sea urchin have many medicinal values determined through modern research. In this paper, we summarized the major chemical constituents and medicinal value of the sea urchin.