Bing Mu

Pd-Catalyzed Tandem Cyclization via C–H Arylation and Acylation for the Construction of Polycyclic Scaffolds

The first Pd-catalyzed tandem cyclization of imidazo[1,2-a]pyridines with 2-chlorobenzaldehydes through C-H arylation and acylation is presented for the efficient synthesis of novel 6H-benzo[b]imidazo[5,1,2-de]quinolizin-6-ones. The direct acylation reaction proceeded smoothly without the aid of directing groups and in the presence of air as a clean and free terminal oxidant.

Cyclopalladated ferrocenylimines with ester groups for Heck and Suzuki coupling reactions

Cyclopalladated ferrocenylimine dimers and cyclopalladated ferrocenylimine monomers were designed and prepared. They were characterized using 1H NMR, 13C NMR, and IR spectroscopies, and MS. The catalytic properties of these compounds in Heck and Suzuki coupling reactions in water or organic solvents were systematically investigated. The results showed that these catalysts could effectively catalyze Heck and Suzuki coupling reactions of aryl or heteroaryl halides in water or organic solvents.