Bing Y. Luh

Stereoselective synthesis of 1-β-methylcarbapenem

Stereoselective syntheses of the 1-β-methylcarbapenem intermediates 9B (R=SPh or OCH3) have been accomplished by an aldol-type stereocontrolled reaction and stereoselective catalytic hydrogenation of an olefinic ester.

Phosphonate Isosteres of 2′,3′-Didehydro-2,3-dideoxynucleoside Monophosphates: Synthesis and Anti-HIV Activity

Abstract Phosphonate analogues of d4T and d4A monophosphates have been synthesized using stereocontrolled addition of dimethyl hydroxymethylphosphonate to furanoid glycals. The new phosphonates exhibited a potent activity against HIV.

Synthesis of a Phosphonate Isostere of Acycylovir Monophosphate: A Herpesvirus Active Phosphonate Nucleotide Analogue

A novel synthetic methodology for the acyclic acetal functionality was developed. The rationally designed phosphonate analogue (3) of acyclovir monophosphate was active against herpesvirus

Synthesis of a phosphonate isostere of ganciclovir monophosphate: A highly cytomegalovirus active phosphonate nucleotide analogue

Abstract A novel synthetic methodology for the hydroxymethyl substituted acyclic acetal functionality was developed, The rationally designed phosphonate analogue 3 of ganciclovir monophosphate was highly active against human cytomegalovirus.

A novel synthesis of 1-OXA-HPMPA: a potent antiviral agent against herpesviruses

Abstract A facile synthesis of 1-oxa-HPMPA 2 was achieved via a novel strategy of coupling 9-hydroxyadenine 13 and enol ether phosphonate 11. The newly synthesized 1-oxa analogue of HPMPA exhibited potent antiherpesvirus activity.

Me3Al-TMSOSO2CF3 a new reagent for conversion of carbonyl to geminal dimethyl functionality : regiospecific synthesis of alkylated a ring of arotinoids

Abstract Regiospecific synthesis of alkylated A ring of arotinoids has been achieved by using Me 3 Al-TMSOSO 2 CF 3 as a key reagent for conversion of carbonyl to a geminal dimethyl functionality.

Phosphonate Isosteres of Acyclovir and Ganciclovir Honophosphates Synthesis and Anti-Herpesvirus Activity

Abstract Isosteric phosphonate analogues of acyclovir and ganciclovir monophosphates were synthesized. The new phosponates exhibited good anti-herpes activity.

Synthesis and anti-HIV activity of 9-[(2R-5R)-2,5-dihydro-5-(phosphonomethoxy)-2-furanyl]-2,6-diaminopurine

Abstract The synthesis of 9-[(2R,5R)-2,5-dihydro-5-(phosphonomethoxy)-2-furanyl]-2,6-diaminopurine ( 2 ) is described. This compound exhibited good inhibitory activity against HIV replication in MT-4 cells.

Synthesis and Biological Activities of Phosphonylalkylpurine Derivatives

Abstract Syntheses and biological activities of 2-phosphonylmethoxy-ethyl (PME) purine analogs are described.

(2R, 4S, 5S)-1-(tetrahydro-4-hydroxy-5-methoxy-2-furanyl)thymine: a potent selective inhibitor of herpes simplex thymidine kinase

Abstract A series of thymidine analogues substituted with alkoxy groups of the C-4 position of the furan ring were synthesized. Among these compounds, the methoxy analogue 9 was the most potent inhibitor of herpes simplex virus type 1 thymidine kinase.