Birgit Oppmann | Researchain

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Immunity | 2000

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

Birgit Oppmann; Robin Lesley; Bianca Blom; Jackie C. Timans; Yuming Xu; Brisdell Hunte; Felix Vega; Nancy Yu; Jing Wang; Komal Singh; Francesca Zonin; Elena Vaisberg; Tatyana Churakova; Man-ru Liu; Daniel M. Gorman; Janet Wagner; Sandra Zurawski; Yong-Jun Liu; John S. Abrams; Kevin W. Moore; Donna M. Rennick; Rene de Waal-Malefyt; Charles Hannum; J. Fernando Bazan; Robert A. Kastelein

A novel sequence discovered in a computational screen appears distantly related to the p35 subunit of IL-12. This factor, which we term p19, shows no biological activity by itself; instead, it combines with the p40 subunit of IL-12 to form a novel, biologically active, composite cytokine, which we term IL-23. Activated dendritic cells secrete detectable levels of this complex. IL-23 binds to IL-12R beta 1 but fails to engage IL-12R beta 2; nonetheless, IL-23 activates Stat4 in PHA blast T cells. IL-23 induces strong proliferation of mouse memory (CD4(+)CD45Rb(low)) T cells, a unique activity of IL-23 as IL-12 has no effect on this cell population. Similar to IL-12, human IL-23 stimulates IFN-gamma production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells.

Archive | 2000

Mammalian cytokines; related reagents and methods

Birgit Oppmann; Jacqueline C. Timans; Robert A. Kastelein; J. Fernando Bazan

Archive | 2000

Mammalian cytokine complexes

Birgit Oppmann; Jacqueline C. Timans; Robert A. Kastelein; J. Fernando Bazan

Archive | 2006

IL-12P40 and IL-B30 polypeptide complex

Birgit Oppmann; Rene de Waal Malefyt; Donna Rennick; Robert A. Kastelein; Maria T. Wiekowski; Sergio A. Lira; Satwant K. Narula

Archive | 2009

Mammalian cytokines, reagent and method thereof

Birgit Oppmann; Rene de Waal Malefyt

Archive | 2000

Interleukin-12 P40 et interleukin B30 de mammifères, anticorps, utilisation dans des compositions pharmaceutiques

Birgit Oppmann; Waal Malefyt Rene De; Donna M. Rennick; Robert A. Kastelein; Maria T. Wiekowski; Sergio A. Lira; Satwant K. Narula

Archive | 2000

Cytokines mammiferes; reactifs afferents et procedes

Birgit Oppmann; Waal Malefyt Rene De; Donna M. Rennick; Robert A. Kastelein; Maria T. Wiekowski; Sergio A. Lira; Satwant K. Narula

Archive | 2000

Cytokines de mammifere : reactifs et procedes associes

Birgit Oppmann; Jacqueline C. Timans; Robert A. Kastelein; J. Fernando Bazan

Archive | 2000

Interleukine-12 p40 et interleukine b30. combinations. anticorps. utilisation dans des compositions pharmaceutiques.

Birgit Oppmann; Waal Malefyt Rene De; Donna M. Rennick; Robert A. Kastelein; Maria T. Wiekowski; Sergio A. Lira; Satwant K. Narula

Archive | 2000

Interleukin-12 p40 und interleukin-b30. Interleukin-12 p40 and interleukin-b30. kombinationen davon. combinations thereof. antikörper. antibody. verwendungen in pharmazeutische zusammensetzungen uses in pharmaceutical compositions

Waal Malefyt Rene De; Robert A. Kastelein; Sergio A. Lira; Satwant K. Narula; Birgit Oppmann; Donna M. Rennick; Maria T. Wiekowski

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