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Dive into the research topics where Birgül Mazmanci is active.

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Featured researches published by Birgül Mazmanci.


Mutation Research-genetic Toxicology and Environmental Mutagenesis | 2003

Cytogenetic effects of lambda-cyhalothrin on Wistar rat bone marrow.

Ayla Çelik; Birgül Mazmanci; Yusuf Çamlica; Ali Aşkin; Ülkü Çömelekoǧlu

In this study, the genotoxic and cytotoxic potential of lambda-cyhalothrin (LCT), a synthetic pyrethroid insecticide, was investigated in Wistar rat bone-marrow cells, using the structural chromosomal aberration (SCA) and micronucleus (MN) test systems. LCT was administrated to adult female albino rats as repeated i.p. doses of 6.12, 3.06, 0.8 mg/kg BW for 13 days at 48 h intervals. Mitomycin C (MMC) was used as a positive control (2 mg/kg BW). All the doses of LCT increased the number of structural chromosomal aberrations and the frequency of micronucleated erythrocytes, compared with the control group. It was also observed that LCT caused a significant decrease in the number of polychromatic erythrocytes. Our results demonstrate that LCT has a clastogenic/genotoxic potential as measured by the bone marrow SCA and MN tests in Wistar rats.


Toxicon | 2010

Antioxidant enzyme activity and lipid peroxidation in liver and gill tissues of Nile tilapia (Oreochromis niloticus) following in vivo exposure to domoic acid.

Birgül Mazmanci; Tolga Çavaş

Domoic acid (DA) is a neurotoxicant produced by Pseudo-nitzschia from diatomeae. Although the neurotoxic and genotoxic effects of DA have been well documented, the number of in vivo studies regarding the oxidative stress inducing effects of DA is quite limited. In this study, in vivo toxic effects of DA were investigated on fish Oreochromis niloticus (Fam: Cichlidae), using oxidative stress biomarkers. Fish were exposed to three different concentrations (1, 5 and 10 microg/g body weight) of DA via intraperitoneal injections and the tissues were sampled at 24, 48 and 72 h post-treatment. Changes in the level of lipid peroxidation, and activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GRd) were evaluated in liver and gill tissues. Our results revealed dose and time dependent increases in the oxidative stress parameters. It was also observed that the toxic effects were more pronounced in liver than in gill tissue.


Toxicology and Industrial Health | 2011

Oxidative stress response in Nile tilapia (Oreochromis niloticus) exposed to textile mill effluent

Abuzer Zagal; Birgül Mazmanci

Textile mill effluent is an important pollution factor because of its organic and inorganic substances content. In this study, toxic effects of textile mill effluent on fish Oreochromis niloticus were investigated by using antioxidant enzymes and lipid peroxidation (LPO) responses. Superoxide dismutase (SOD), catalase (CAT) enzyme activities and lipid peroxidation by means of thiobarbituric reactive substances (TBARS) level were measured in liver and gill tissues of fish. The fish were exposed to non-lethal concentrations (0.1%, 1% and 10%) of textile mill effluent for 15, 30 and 45 days. In control group, fish were left in aquariums containing tap water without chlorine. As a result, the activities of SOD, CAT enzymes and level of TBARS in the liver and gill increased in 15, 30 and 45 days after 1% and 10% doses application.


Archive | 2014

PyHasse Software Features Applied on the Evaluation of Chemicals in Human Breast Milk Samples in Turkey

Kristina Voigt; Rainer Brüggemann; Hagen Scherb; Ismet Cok; Birgül Mazmanci; M. Ali Mazmanci; Cafer Turgut; Karl-Werner Schramm

In this chapter we evaluate the data of 18 Organochlorine pesticides (OCPs) found in breast milk samples from 44 mothers in the Taurus Mountains in Turkey. In this approach the association of concentration levels in breast milk samples with the two confounding factors: smoking habit and habit of taking medication is the goal. For all data evaluation approaches, we applied the Hasse diagram technique and its software package, namely the PyHasse software. Special emphasis was laid on the software features “similarity” and “Local Partial Order Model” to draw further conclusions out of the data. The data analyses resulted in differences between the smoking women and those who did not smoke as well as between the medication and non-medication breast milk samples. Little differences were found comparing hormone taking mothers and mothers taking other medication.


Environment International | 2012

Analysis of human milk to assess exposure to PAHs, PCBs and organochlorine pesticides in the vicinity Mediterranean city Mersin, Turkey

Ismet Cok; Birgül Mazmanci; Mehmet Ali Mazmanci; Cafer Turgut; Bernhard Henkelmann; Karl-Werner Schramm


Ecotoxicology and Environmental Safety | 2005

Evaluation of cytogenetic effects of lambda-cyhalothrin on Wistar rat bone marrow by gavage administration.

Ayla Çelik; Birgül Mazmanci; Yusuf Çamlica; Ulku Comelekoglu; Ali Aşkin


Mutagenesis | 2005

Induction of micronuclei by lambda-cyhalothrin in Wistar rat bone marrow and gut epithelial cells.

Ayla Çelik; Birgül Mazmanci; Yusuf Çamlica; Ali Aşkin; Ükü Çömelekoğlu


Environmental Science and Pollution Research | 2012

The occurrence and environmental effect of persistent organic pollutants (POPs) in Taurus Mountains soils.

Cafer Turgut; Levent Atatanir; Birgül Mazmanci; Mehmet Ali Mazmanci; Bernhard Henkelmann; Karl-Werner Schramm


Food Chemistry | 2011

Protective effect of Funalia trogii crude extract on deltamethrin-induced oxidative stress in rats

Birgül Mazmanci; Mehmet Ali Mazmanci; Ali Ünyayar; Serpil Ünyayar; Fazilet Özlem Çekiç; Aysin Guzel Deger; Serap Yalin; Ulku Comelekoglu


International Journal of Environmental Health Research | 2013

Evaluation of organochlorine pesticides in breast milk samples in Turkey applying features of the partial order technique.

Kristina Voigt; Rainer Brüggemann; Hagen Scherb; Ismet Cok; Birgül Mazmanci; M. Ali Mazmanci; Cafer Turgut; Karl-Werner Schramm

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Cafer Turgut

Adnan Menderes University

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Mehmet Berköz

Yüzüncü Yıl University

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