Bodo Baumeister

Giant Artificial Ion Channels Formed by Self-Assembled, Cationic Rigid-Rodβ-Barrels

Future stochastic biomimetic chemistry within toroidal supramolecules will depend on the availability of large, transmembrane, and functionalized internal space of high stability, four properties that characterize the nanopore formed by the hexameric, cationic rigid-rod s-barrel.

β‐Fibrillogenesis from Rigid‐Rod β‐Barrels: Hierarchical Preorganization Beyond Microns

Ordnung und Asthetik kommen in neuartigen supramolekularen Architekturen zum Ausdruck, die aus praorganisierten starren stabformigen Molekulen aufgebaut sind. Nach Selbstorganisation zu einer Fass-artigen Tertiarstruktur (links) bildet sich eine Quartarstruktur hoherer Ordnung (rechts), die aus starren stabformigen s-Fibrillen besteht.

Programmed assembly of expanded rigid-rodβ-barrels by supramolecular preorganization

A simple strategy for (a) expansion and (b) variation of the internal chemical nature of rigid-rod β-barrels is reported, and the importance of supramolecular preorganization for their programmed assembly is discussed.

Bioorganic Chemistry of Rigid-Rod Molecules: Adventures with p-Oligophenyls

Studies on the usefulness of rigid-rod molecules to address pertinent questions of biological relevance are summarized. Emphasis is placed on (a) the supramolecular functional plasticity of p-octiphenyl s-barrels expressed in molecular recognition (adaptable synthetic hosts), molecular translocation (adaptable synthetic ion channels) and molecular transformation (esterases, RNases), (b) molecular recognition of polarized membranes by rigid push-pull rods, as well as (c) the synthetic organic chemistry of rigid-rod molecules.

Catalytic Rigid-Rod β-Barrels with Hydrazide Cofactors to Convert Poor Substrates as Hydrazone Conjugates

The usefulness of pyrene-1,3,6-trisulfonates as cofactors for p-octiphenyl β-barrel ion channels to mediate recognition and conversion of otherwise inaccessible benzaldehyde substrates is described.