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Featured researches published by Bogdan Falkiewicz.


Gene | 1998

Amplification of erbB-4 oncogene occurs less frequently than that of erbB-2 in primary human breast cancer.

Ulf Vogt; Krzysztof Bielawski; Claus M. Schlotter; Ulrich Bosse; Bogdan Falkiewicz; Anna J. Podhajska

ErbB-4 protein is a recently discovered member of the ErbB family. The role of ErbB-4 protein in mammary-gland tissue has not been definitively established. To date, the expression of erbB-4 in breast tissue has been determined in only a few cases and, to the best of our knowledge, its amplification has not been examined. We therefore used the double differential polymerase chain reaction (ddPCR) for determination of the amplification profile of erbB-4 and erbB-2, another gene from the ErbB family, in human primary breast cancer specimens. We examined the amplification of the genes in 20 normal breasts and 176 invasive breast cancer samples. Amplification of erbB-2 was detected in 19% and erbB-4 in 13% of the samples studied. Co-amplification of the two oncogenes was found in only five out of 176 samples. Human breast cancer-derived cell lines in most cases overexpress both erbB-2 and erbB-4 (Beerli et al., 1995. Mol. Cell Biol. 15, 6496-6505; Han et al., 1995. Proc. Natl. Acad. Sci. USA 92, 9747-9751), but data on separate erbB-2 overexpression, without overexpression of erbB-4, were also reported (Wosikowski et al., 1997. Clin. Cancer Res. 3, 2405-2414). At the gene level, we found that co-amplification of the genes in the case of human breast cancer is rare. Moreover, an inverse association of the erbB-4 amplification with estrogen receptor activity and direct correlation with the tumor size were found. Due to these correlations, erbB-4 oncogene amplification can be assumed to be of prognostic or predictive value in the diagnosis of breast cancer.


Archives of Medical Research | 2000

HCV infection in Poland.

Krzysztof Bielawski; Mikolaj Wlasiuk; Malgorzata Truskolawska; Bogdan Falkiewicz

BACKGROUNDnHepatitis C virus (HCV) infection is one of the most prevalent infectious diseases in the world. In 1997, hepatitis C became a statutorily noticeable disease in Poland. Nevertheless, to date, only a few notable studies on the prevalence of HCV infection have been carried out in Poland. Therefore, a study to determine the prevalence of HCV infection markers in an unselected population of Polish subjects was performed.nnnMETHODSnAfter several advertisements (in the print media and on television, radio, and other public media) concerning free testing for all volunteers in a hospital laboratory, serum samples of 2,561 subjects (765 men and 1,796 women), with a mean age of 43 years (range 1-88 years), were collected and assessed. In the samples, we first tested for the presence of IgG anti-HCV antibodies using the third generation enzyme immunoassay Anti-HCV EIA Cobas(R) Core Test (Hoffmann La Roche, Basel, Switzerland). The determination of HCV-RNA was then performed on anti-HCV IgG-positive samples by qualitative reverse transcription-polymerase chain reaction (RT-PCR) by automatic Cobas Amplicor (Roche Molecular Systems Hepatitis C Virus Test 2.0, Roche Molecular Systems, Nutley, NJ, USA).nnnRESULTSnThe presence of anti-HCV IgG was detected in a total of 48 cases (1.9%). Prevalence was significantly higher in men (2.3%) than in women (1.7%) (p = 0.0057), but was not significantly related to the subjects age (p = 0.51) or domicile (p = 0.35). The presence of HCV-RNA was detected in 31 (65%) anti-HCV-positive cases tested, with no significant relationship to either the age (p = 0.15), domicile (p = 0.24), or gender (p = 0.79) of the subjects.nnnCONCLUSIONSnTo the best of our knowledge, this is the largest study on the prevalence of HCV infection in the general population in Poland. The study has several limitations, such as, the use of a nonrandomized population. Nevertheless, the results obtained may be more realistic and applicable to the general population in Poland than those obtained previously (i.e., in voluntary blood donors).


International Journal of Infectious Diseases | 1999

Hepatitis G virus: molecular organization, methods of detection, prevalence, and disease association.

Magdalena Robaczewska; Lucyna Cova; Anna J. Podhajska; Bogdan Falkiewicz

This article reviews data on hepatitis G virus (HGV) prevalence and possible disease associations in various groups of patients. An important fraction of acute or chronic hepatitis cases probably have a viral etiology and are not attributable to known hepatitis viruses. Therefore, researchers continually are looking for new hepatitis viruses. Among the agents found are members of GB hepatitis viruses, including GB-C virus, or HGV. This review presents the history of the discovery of HGV, its molecular biology and some methods of detection; results of clinical and molecular studies of HGV infection also are discussed.


Nucleosides, Nucleotides & Nucleic Acids | 2001

RESTRICTED ROTATION IN CHIRAL PEPTIDE NUCLEIC ACID (PNA) MONOMERS - INFLUENCE OF SUBSTITUENTS STUDIED BY MEANS OF 1H NMR

Marta Oleszczuk; Sylwia Rodziewicz-Motowidło; Bogdan Falkiewicz

The influence of amino acid side chains [derived from: Ala, Val, Leu, Ile, Phe, Tyr(Bzl), Ser(Bzl), Thr(Bzl), Pro, Trp], incorporated into “aminoalkyl” part of PNA monomers, on the temperature-dependent distributions of rotamers about the tertiary amide bond was studied by means of 1H NMR at 0, 25 and 40°C in CDCl3. The ΔG0 values of the energy differences between individual rotamers were calculated. The results may be helpful in the designing of monomers with desirable properties.


Acta Biochimica Polonica | 2000

Relationship of c-myc and erbB oncogene family gene aberrations and other selected factors to ex vivo chemosensitivity of ovarian cancer in the modified ATP-chemosensitivity assay.

Ulf Vogt; Bogdan Falkiewicz; Krzysztof Bielawski; Ulrich Bosse; Claus M. Schlotter


Biofactors | 2000

Zinc deficiency and normal contents of magnesium and calcium in metabolic X syndrome patients as assessed by the analysis of hair element concentrations.

Bogdan Falkiewicz; Ewa Dąbrowska; Jerzy Łukasiak; Daniel Cajzer; Irena Jabłońska‐Kaszewska


Biofactors | 2000

Analysis of calcium, magnesium, and zinc levels in hair of healthy students. Screening of calcium or magnesium deficiency hazard

Jerzy Łukasiak; Irena Jabłońska‐Kaszewska; Daniel Cajzer; Ewa Dąbrowska; Bogdan Falkiewicz


Oncology Reports | 2002

Gene copy numbers of erbB oncogenes in human pheochromocytoma

Krzysztof Sworczak; Anna J. Zaczek; Anna Babińska; Urszula Lisowska; Krzysztof Bielawski; Bogdan Falkiewicz


Acta Biochimica Polonica | 2000

c-myc Oncogene gene dosage, serum CEA and CA-15.3 antigen levels, and cellular DNA values in relation to ex vivo chemosensitivity of primary human breast cancer

Bogdan Falkiewicz; Claus M. Schlotter; Ulrich Bosse; Krzysztof Bielawski; Ulf Vogt


Biofactors | 2000

Abnormalities in serum copper and iron concentrations in porphyria cutanea tarda patients and their relationships with other parameters

Ewa Dąbrowska; Irena Jabłońska‐Kaszewska; Jerzy Łukasiak; Agnieszka Dorosz; Bogdan Falkiewicz

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