Bojan Ramadanovic

Finite size giant magnon

The quantization of the giant magnon away from the infinite size limit is discussed. We argue that this quantization inevitably leads to string theory on a Z{sub M} orbifold of S{sup 5}. This is shown explicitly and examined in detail in the near plane-wave limit.

Free energy and phase transition of the matrix model on a plane wave

It has recently been observed that the weakly coupled plane-wave matrix model has a density of states which grows exponentially at high energy. This implies that the model has a phase transition. The transition appears to be of first order. However, its exact nature is sensitive to interactions. In this paper, we analyze the effect of interactions by computing the relevant parts of the effective potential for the Polyakov loop operator in the finite temperature plane-wave matrix model to three-loop order. We show that the phase transition is indeed of first order. We also compute the correction to the Hagedorn temperature to order two loops.

Changing Risk Behaviours and the HIV Epidemic: A Mathematical Analysis in the Context of Treatment as Prevention

Background Expanding access to highly active antiretroviral therapy (HAART) has become an important approach to HIV prevention in recent years. Previous studies suggest that concomitant changes in risk behaviours may either help or hinder programs that use a Treatment as Prevention strategy. Analysis We consider HIV-related risk behaviour as a social contagion in a deterministic compartmental model, which treats risk behaviour and HIV infection as linked processes, where acquiring risk behaviour is a prerequisite for contracting HIV. The equilibrium behaviour of the model is analysed to determine epidemic outcomes under conditions of expanding HAART coverage along with risk behaviours that change with HAART coverage. We determined the potential impact of changes in risk behaviour on the outcomes of Treatment as Prevention strategies. Model results show that HIV incidence and prevalence decline only above threshold levels of HAART coverage, which depends strongly on risk behaviour parameter values. Expanding HAART coverage with simultaneous reduction in risk behaviour act synergistically to accelerate the drop in HIV incidence and prevalence. Above the thresholds, additional HAART coverage is always sufficient to reverse the impact of HAART optimism on incidence and prevalence. Applying the model to an HIV epidemic in Vancouver, Canada, showed no evidence of HAART optimism in that setting. Conclusions Our results suggest that Treatment as Prevention has significant potential for controlling the HIV epidemic once HAART coverage reaches a threshold. Furthermore, expanding HAART coverage combined with interventions targeting risk behaviours amplify the preventive impact, potentially driving the HIV epidemic to elimination.

Control of an HIV epidemic among injection drug users: simulation modeling on complex networks

HIV remains a serious public health problem in many marginalized communities. We develop a network model of the HIV epidemic affecting injection drug users and female sex workers in the Downtown Eastside neighborhood of Vancouver, Canada, calibrated using data from public health surveillance and cohort studies. Many HIV positive individuals are unaware of their status and strategies for testing are an important part of HIV response programs. Upon diagnosis, HIV patients enter a continuum of care, involving both engagement and retention in treatment. We explored potential epidemic control strategies through simulation: reduced syringe sharing during injection drug use, reduced time to diagnosis, reduced time to initiation of treatment following diagnosis, and improved retention in treatment. We find that syringe sharing, HIV testing, and retention in treatment significantly impact HIV prevalence. Close connections between syringe sharing and sexual networks deserve attention as important avenues for rapid HIV transmission.