Bong Seok Shin

Clinical characteristics and risk of melanoma development from giant congenital melanocytic naevi in Korea: a nationwide retrospective study.

Background  Giant congenital melanocytic naevi (GCMN) are known risk factors for the development of melanoma. However, melanoma risk among Asians is rarely evaluated.

A case of human immunodeficiency virus infection initially presented with disseminated herpes zoster.

Herpes zoster is characterized by unilateral grouped vesicles along the distribution of a single dermatome. Disseminated herpes zoster usually is defined as a generalized eruption of more than 20 extra-dermatomal vesicles occurring within a week of the onset of classic dermatomal herpes zoster. It occurs chiefly in old or debilitated individuals, and especially in patients with underlying malignancy, immunosuppressive therapy, or human immunodeficiency virus (HIV) infection. A 51-year-old man presented with segmental grouped vesicles on the left upper trunk and arm, and a varicella-like eruption over the entire body. Tzanck smear preparation and punch biopsy done on the vesicles of the trunk indicated a herpetic infection. Later, he was found to be HIV-positive. We report a rare case of HIV infection initially presenting with disseminated herpes zoster.

Cutaneous Extraskeletal Osteosarcoma on the Scar of a Previous Bone Graft

Extraskeletal osteosarcoma (ESOS) is a very rare malignant tumor of mesenchymal origin. It is rarer than osseous osteosarcoma and there are very few reports of the skin being a primary site. Most reported cutaneous ESOS were accompanied with metastasis in other organs. A 56-year-old man presented with a painful, 1.5×0.8 cm sized, brown-colored nodule on the right girdle area for 3 months. The histologic findings revealed a tumor that was confined to the dermis without connection to the subcutaneous tissue. In addition, there were large amounts of thin and lace-like bony trabeculae and osteoid with neoplastic cells in a highly pleomorphic sarcomatous stroma.

Calcinosis cutis in systemic lupus erythematosus: A case report and review of the published work

Calcinosis cutis is a common clinical feature of dermatomyositis and scleroderma but rarely reported in association with systemic lupus erythematosus (SLE). Calcinosis cutis in SLE occurs without calcium and phosphorus metabolic abnormalities and may be localized or generalized. The pathophysiology remains unclear and no effective therapy is currently available. We report a 30‐year‐old woman with a 13‐year history of SLE who developed multiple calcinosis cutis around both knees and we review the relevant published work.

Prevalence and Factors Associated with Neonatal Occipital Alopecia: A Retrospective Study

Background For many years, the etiology of neonatal occipital alopecia (NOA) has been thought to be friction. It is recently clear that NOA is related to the physiological hair shedding. Objective We sought to evaluate the prevalence and factors associated with NOA. Methods Medical records of 240 postpartum patients who had been delivered between January 2006 and June 2007 at our institution were reviewed. Phone interviews with 193 respondents were conducted to investigate the actual conditions of NOA. Results NOA was present in 39 babies (20.2%). Univariate analysis showed that NOA was not associated with the babys sleeping position, but was significantly associated with maternal parturition age, the delivery method, and the gestational age (p<0.05). In multiple logistic regression analysis, the risk of NOA was higher in the group younger than 35 years at parturition (OR, 3.86; 95% CI, 1.08~13.82), in the group not undergoing a Caesarean-section delivery (2.47; 1.09~5.60), and in the group delivered after 37 weeks of gestational age (3.36; 1.22~9.26). Conclusion The pregnancy-related factors, such as non-elderly gravida, non-Caesarean-section delivery, and enough gestational age, were associated with NOA. These findings support the recent theory that NOA is not an acquired alopecia, but a physiological condition, resulting from synchronized shedding of telogen hairs initiated in utero.

Case of herpes zoster duplex bilateralis

Non‐contiguously simultaneous development of herpes zoster is very rare. It is named either herpes zoster duplex unilateralis or bilaterarlis, depending on whether one or both sides of the body are involved. Herein, we report a 21‐year‐old man, who had been treated for ulcerative colitis with prednisolone, and presented with painful grouped vesicles of the lower abdomen and back in a relatively symmetrical distribution. A Tzanck smear and punch biopsy were performed on the vesicles of the back. We report a rare case of symmetrical herpes zoster duplex bilateralis.

Successful treatment of molluscum contagiosum with intralesional immunotherapy by measles, mumps, and rubella vaccine: a report of two cases

Molluscum contagiosum (MC) is a common viral infection of the skin and mucous membrane that often affects young children. Generally, physical removal by surgical curettage is commonly used for the treatment of MC, but the pain during the treatment is a major problem. Thus immunotherapy using various antigens has been introduced recently. Here we present two cases of MC that improved with measles, mumps, and rubella (MMR) vaccine intralesional injection. On the ground of our knowledge, they were the first cases of successful MMR intralesional injection in this disease entity.

Allergic reaction to hyaluronidase use after hyaluronic acid filler injection

Abstract Hyaluronic acid (HA) is biocompatible, easy to use and reversible. HA fillers are considered to be safe, although some complications can occur. At this time, hyaluronidase is used off-label for correction. A 41-year-old woman presented to our clinic for focal erythematous plaque on hyaluronidase injection site. She got the injection for correction of HA filler excess. The skin lesion continued for 7 days. Histopathologic findings were nonspecific. On intradermal skin test, allergic reaction to hyaluronidase were confirmed. Adverse effects of this hyaluronidase are uncommon with local injection site reactions most frequently reported. Allergy to hyaluronidase should be included in the differential diagnosis when focal erythema and swelling occur after hyaluronidase injection.

Rapid Growing Superficial Cutaneous Leiomyosarcoma of the Face

Leiomyosarcomas are uncommon malignant smooth muscle tumors, mainly derived from vessels or viscera. Superficial leiomyosarcomas are a rare soft tissue sarcoma arising from the dermis or subcutaneous tissue in the skin. According to tumor origin and location, they are divided into cutaneous and subcutaneous leiomyosarcoma. They have distinctly different histologic and prognostic features from each other. Superficial leiomyosarcomas show a predilection for the proximal extremities and tend to be slow growing. We report one rare case of superficial cutaneous leiomyosarcoma on the right temporal area of face, which showed an extremely rapid growing mass within 3 months.

Giant ectopic hidradenoma papilliferum on the scalp

Dear Editor, Hidradenoma papilliferum (HP) is a rare benign cystic neoplasm that occurs almost exclusively on the anogenital region of women. Histopathologically, cells in HP show active decapitation because this tumor is derived from apocrine glands. It usually occurs as a unilateral, small, asymptomatic, skincolored or red nodule of approximately 5 mm in diameter (range, 0.1–1.0 cm). However, HP in nonanogenital areas occasionally have been reported and are called ‘‘ectopic HP’’. We report a giant ectopic HP occurring on the scalp. A 70-year-old woman presented with a large cystic mass on the scalp. It had developed as a slowly growing, asymptomatic cystic tumor for 3 years. Her past medical history was contributory to hypertension and chronic thyroiditis with thyroid nodule. On close examination, the left frontoparietal area had a protruding, heart-shaped, 5 cm · 4.5 cm · 4 cm sized, and dusky-bluish cystic nodule with a marked telangiectatic surface and soft consistency, like a jelly (Fig. 1). She underwent total excision of the tumor and advancement flap coverage at the Department of