Boualem Oussaid

Improved Synthesis of Oxazoline Under Microwave Irradiation

Abstract Oxazolines have been prepared under microwave irradiation by two different ways. In a first one, imino ether hydrochlorides have been reacted with amino alcohols in the presence of alumina supported potassium fluoride, in an open vessel. In a second one, amino alcohols are directly reacted with imino ethers in a closed vessel.

Improved Synthesis of Oxadiazoles Under Microwave Irradiation

Abstract Abstract Amidoximes (1) reacted with isopropenyl acetate in presence of KSF under microwave irradiation and gave 1,2,4-oxadiazoles (2). 1,2,4-Oxadiazoles (4) can also be obtained by microwave irradiation from O-acylamidoximes (3) adsorbed on Alumina. 1,3,4-Oxadiazoles (6) were obtained by irradiation of bis (acyl) hydrazines (5) in thionyl chloride.

THIOPHENE-CONTAINING MACROCYCLES DERIVED FROM [2 + 2] CYCLIZATIONS

Abstract Tetra ester macrocycles 7, 8, carboxamide macrocycles 9a, b and Schiff base macrocycles 10, 12a, b containing two or four thiophene moieties are obtained from 2,5-thiophene dicarbonylchloride or various aldehydes and esters derived from thiophene.

SYNTHESE D'OXADIAZOLES ET D'OXAZOLES THIOPHENIQUES

Abstract Some potentially active drugs: oxadiazoles (4, 8, 17), oxazoles (10, 12a, 12b, 13) heterocycles substituted by a thiophenic moiety have been prepared by a multistep procedure.

The Atherton-Todd Reactions Under Sonochemical Activation

Abstract 1a-g phosphorylation is performed in the Atherton-Todd reaction conditions (mixture of diethylphosphonate and carbone tetrachloride and triethylamine under ultrasonic irradiation). The expected phosphates 2a-g are obtained in good yields.

Mécanismes de Formation d'α-Aminophosphonates

When di-n-decylphosphonate 1a or di-benzylphosphite 1b are reacted with furan imine 2a or thiophenic imine 2b , the reaction leads to an f -aminophosphonate: 3a , 3b , or 3c following an ion- or radical-based reaction.

SYNTHESE DE NOUVEAUX DERIVES DU THIOPHENE

Abstract New potentially active drugs derivatives of 2,5-disubstituted thiophene are synthesized by a multistep procedure. An alcohol solution of ammonia reacts with 2-formyl thiophene to form the gem-diimine 8. The oxide of benzonitrile reacts with 2-[(methylimino)methyl] or 3-[(methylimino)methyl] thiophene to form the corresponding-1,2,4 oxadiazolines (9 and 10).

Ene Réaction et Réaction de Substitution sur Des Hétérocycles Catalysées par les Sels de Bi(III)

Carbonylated electrophiles react with furan, thiophene, or pyrrole derivatives in the presence of catalytic amounts of bismuth triflate or chloride, leading to either electrophilic substitution or ene reaction products.

IN-SITU SYNTHESES OF ALKYLLITHIUM COMPOUNDS UNDER ULTRASONIC IRRADIATION

Abstract The syntheses of organometallics such as alkyllithium compounds are performed. Furan and thiophene derivatives were prepared. Parameters which influence the yield have been optimized. The more important were the physical states of lithium and its sodium content and the nature of the substrate.

Synthese de thieno [2,3-a] quinolizidines

Abstract Condensation of the chlorhydrate of the 4,5 dihydro [2,3-c] thienopyridine 5 with methylvinylketone leads to a heterocyclic system 6. This compound has been transformed, in three steps into N-benzoyl thieno [2,3-a] quinolizidine 9 which is an analogue of the hypotensive agent indoramine.