Brandy R. Matthews

Hospitalization Is Associated with Changes in Cognition and Brain Structure

Hospitalization is common among older patients, and concern is escalating that hospitalization may be associated with cognitive decline in this group.

Mild Cognitive Impairment Linked to Concussion in Retired NFL Players

Although most people with concussion recover clinically within days to weeks, some have more persistent neurobehavioral changes, including episodic

Research Agenda for Alzheimer and Non-Alzheimer Dementias

The National Alzheimers Project Act, signed into U.S. law in 2011, requires an annually updated “National Plan to Address Alzheimers Disease,”

Tau Targeted but Trial Negative in Progressive Supranuclear Palsy

Progressive supranuclear palsy (PSP) is a relatively rare neurodegenerative cause of atypical parkinsonism associated with eye-movement abnormalities, axial rigidity, frequent falls, and a frontal-type behavioral syndrome. Characteristic neuropathology is four microtubule-binding repeat (4R) tau in the neurons and glia of the brainstem, basal ganglia, and cerebellar nuclei, with variable cortical involvement. Davunetide, an investigational agent derived from activity-dependent neuroprotective …

Neurologists Acknowledge High Level of Physician Burnout

Physician burnout is the experience of emotional exhaustion (loss of interest in practice), depersonalization (treating patients as objects), and

Neurodegeneration in Athletes and Veterans

Traumatic brain injury (TBI) and related neurodegeneration among athletes and military personnel is garnering more attention from the media, from the

Past Infections Are Tied to Cognitive Impairment

To examine a possible association between infection and cognitive impairment, researchers analyzed blood samples from more than 1600 multiethnic adults without prior stroke and created a composite measure of exposure to Chlamydia pneumoniae , Helicobacter pylori , cytomegalovirus, and herpes …

Late-Onset Alzheimer Disease Susceptibility Genes in Black Americans

The incidence of late-onset Alzheimer disease (LOAD) is higher in blacks than in whites living in the same area of the U.S. To investigate the cause of this difference, a collaborative group of researchers has undertaken the largest genome-wide association study of LOAD in black Americans to date. They used data from 1968 blacks with …

Dementia Outpaces Cancer in Financial Burden to United States

The greatest risk factor for dementia is advancing age. Therefore, with the aging of the population, the prevalence of dementia is increasing. The U.S.

Depression and Cognitive Impairment in Older Adults

Performance on tasks intended to assess cognition and measures of mood symptoms are related. At least half of patients diagnosed with Alzheimer disease