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Brent S. Gaylord

University of California, Santa Barbara

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Publication

Featured researches published by Brent S. Gaylord.

Proceedings of the National Academy of Sciences of the United States of America | 2002

DNA detection using water-soluble conjugated polymers and peptide nucleic acid probes

Brent S. Gaylord; Alan J. Heeger; Guillermo C. Bazan

The light-harvesting properties of cationic conjugated polymers are used to sensitize the emission of a dye on a specific peptide nucleic acid (PNA) sequence for the purpose of homogeneous, “real-time” DNA detection. Signal transduction is controlled by hybridization of the neutral PNA probe and the negative DNA target. Electrostatic interactions bring the hybrid complex and cationic polymer within distances required for Förster energy transfer. Conjugated polymer excitation provides fluorescein emission >25 times higher than that obtained by exciting the dye, allowing detection of target DNA at concentrations of 10 pM with a standard fluorometer. A simple and highly sensitive assay with optical amplification that uses the improved hybridization behavior of PNA/DNA complexes is thus demonstrated.

Journal of the American Chemical Society | 2003

DNA hybridization detection with water-soluble conjugated polymers and chromophore-labeled single-stranded DNA.

Brent S. Gaylord; A.J. Heeger; Guillermo C. Bazan

Journal of the American Chemical Society | 2004

Fluorescein Provides a Resonance Gate for FRET from Conjugated Polymers to DNA Intercalated Dyes

Shu Wang; Brent S. Gaylord; Guillermo C. Bazan

Journal of the American Chemical Society | 2003

Effect of Chromophore-Charge Distance on the Energy Transfer Properties of Water-Soluble Conjugated Oligomers

Bin Liu; Brent S. Gaylord; Shu Wang; Guillermo C. Bazan

Journal of the American Chemical Society | 2001

Water-soluble conjugated oligomers: effect of chain length and aggregation on photoluminescence-quenching efficiencies.

Brent S. Gaylord; Shujun Wang; A.J. Heeger; Guillermo C. Bazan

Proceedings of the National Academy of Sciences of the United States of America | 2005

SNP detection using peptide nucleic acid probes and conjugated polymers: Applications in neurodegenerative disease identification

Brent S. Gaylord; Michelle R. Massie; Stuart C. Feinstein; Guillermo C. Bazan

Advanced Materials | 2002

Energy Transfer in Mixtures of Water‐ Soluble Oligomers: Effect of Charge, Aggregation, and Surfactant Complexation

Martin Stork; Brent S. Gaylord; Alan J. Heeger; Guillermo C. Bazan

Journal of the American Chemical Society | 2004

Perturbation of fluorescence by nonspecific interactions between anionic poly(phenylenevinylene)s and proteins: implications for biosensors.

Stephen J. Dwight; Brent S. Gaylord; Janice W. Hong; Guillermo C. Bazan

Proceedings of the National Academy of Sciences of the United States of America | 2004

Time-resolved energy transfer in DNA sequence detection using water-soluble conjugated polymers: The role of electrostatic and hydrophobic interactions

Qing-Hua Xu; Brent S. Gaylord; Shu Wang; Guillermo C. Bazan; Daniel Moses; Alan J. Heeger

Journal of the American Chemical Society | 2006

PNA/dsDNA Complexes: Site Specific Binding and dsDNA Biosensor Applications

Erin Shammel Baker; Janice W. Hong; Brent S. Gaylord; Guillermo C. Bazan; Michael T. Bowers

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Guillermo C. Bazan

University of California

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Janice W. Hong

University of California

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Glenn P. Bartholomew

Becton Dickinson

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Bin Liu

National University of Singapore

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Yongchao Liang

Becton Dickinson

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Shu Wang

University of California

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Alan J. Heeger

University of California

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Shu Wang

University of California

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Frank Peter Uckert

Becton Dickinson

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A.J. Heeger

University of California

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