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Dive into the research topics where Brian M. Andresen is active.

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Featured researches published by Brian M. Andresen.


Tetrahedron Letters | 2001

The use of borane–amine adducts as versatile palladium-catalyzed hydrogen-transfer reagents in methanol

Michel Couturier; Brian M. Andresen; John L. Tucker; Pascal Dubé; Steven J. Brenek; Joanna Teresa Negri

Abstract The scope of borane–amine adducts as reducing agents is broadened through palladium-catalyzed methanolysis capable of reducing a wide variety of functional groups. Hence, borane mediated reduction of a benzamide followed by a tandem methanolysis/hydrogenolysis of the resulting borane–benzylamine adduct allows chemoselective removal of an N -benzoyl in the presence of an O -benzoyl.


Tetrahedron Letters | 2001

Palladium catalyzed activation of borane–amine adducts: rate enhancement of amine–borane methanolysis in the reduction of nitrobenzenes to anilines

Michel Couturier; John L. Tucker; Brian M. Andresen; Pascal Dubé; Steven J. Brenek; Joanna Teresa Negri

Abstract Hydrolytically stable borane–amines can be activated in situ through palladium catalysis and perform reductions not possible otherwise. Hence, borane–trimethylamine is an efficient hydrogen-transfer reagent for the open vessel reduction of nitroaryls to anilines. Likewise, the palladium catalyzed methanolysis/decomplexation of stable borane–amine adducts is accelerated by the action of nitrobenzene.


Tetrahedron-asymmetry | 2003

Efficient synthesis of the κ-opioid receptor agonist CJ-15,161: four stereospecific inversions at a single aziridinium stereogenic center

Michel Couturier; John L. Tucker; Brian M. Andresen; Keith Michael Devries; Brian C. Vanderplas; Fumitaka Ito

Abstract An efficient four-step sequence has been developed for the synthesis of the κ-opioid receptor agonist CJ-15,161. The process features four consecutive regioselective and stereospecific inversions at a single aziridinium stereogenic center, which leads to overall retention of stereochemistry, in a single operation. The chemistry is straightforward, practical and amenable to large-scale synthesis.


Organic Letters | 2001

Palladium and Raney Nickel Catalyzed Methanolic Cleavage of Stable Borane−Amine Complexes

Michel Couturier; John L. Tucker; Brian M. Andresen; Pascal Dubé; Joanna Teresa Negri


Organic Process Research & Development | 2004

Streamlined Processes for the Synthesis of a Farnesyl Transferase Inhibitor Drug Candidate

Brian M. Andresen; Michel Couturier; Brian Cronin; Michael D'Occhio; Marcus Ewing; Mark Guinn; Joel M. Hawkins; V. John Jasys; Susan D. LaGreca; Joseph P. Lyssikatos; Garrett Moraski; Karl Ng; Jeffrey W. Raggon; A. Morgan Stewart; Derek L. Tickner; John L. Tucker; Frank J. Urban; and Enrique Vazquez; Lulin Wei


Organic Process Research & Development | 2002

Practical Large-Scale Synthesis of 3,4-Isopropylidenedioxypyrrolidine Hydrotosylate: Atom Economical Self-Hydrogenolysis of a Crystalline Borane−Benzylamine Adduct

Michel Couturier; Brian M. Andresen; Jeffrey B. Jorgensen; John L. Tucker; Frank Robert Busch; Steven J. Brenek; Pascal Dubé; David J. am Ende; Joanna Teresa Negri


Archive | 2012

Amino-pyridine-containing spleen tyrosine kinase (syk) inhibitors

Eric Romeo; Michelle R. Machacek; Benjamin Wesley Trotter; Thomas A. Miller; Brian M. Andresen; Neville J. Anthony; Brandon M. Taoka; Yuan Liu


Organic Letters | 2004

Phosphine-mediated [4 + 2] annulation of bis(enones): a Lewis base catalyzed "mock Diels-Alder" reaction.

Michel Couturier; Frederic Menard; John A. Ragan; Maxime Riou; Etienne Dauphin; Brian M. Andresen; Arun Ghosh; Kristina Dupont-Gaudet; Melina Girardin


Chimia | 2006

Process research and scale-up of the κ-opioid receptor agonist CJ-15,161 drug candidate

Brian M. Andresen; Stephane Caron; Michel Couturier; Keith Michael Devries; Nga M. Do; Kristina Dupont-Gaudet; Arun Ghosh; Melina Girardin; Joel M. Hawkins; Teresa Margaret Makowski; Maxime Riou; Janice E. Sieser; John L. Tucker; Brian C. Vanderplas; Timothy J. N. Watson


Organic Process Research & Development | 2005

Process Development of CP-481715, a Novel CCR1 Antagonist

Bryan Li; Brian M. Andresen; Matthew Frank Brown; Richard A. Buzon; Charles K.-F. Chiu; Michel Couturier; Eric Dias; Frank J. Urban; V. John Jasys; John Charles Kath; William Kissel; Tung Le; Z. Jane Li; Joanna Teresa Negri; Christopher Stanley Poss; John L. Tucker; David C. Whritenour; Kathleen Zandi

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