Brian Michael Adger

Stereospecific synthesis of the anaesthetic levobupivacaine

Abstract Enantiomerically pure (S)-Bupivacaine is synthesised from the chiral pool using cheap and readily available (S)-lysine. The key steps in this efficient synthesis include an oxidative de-amination and stereospecific ring closure to form the pipecolamide core structure.

Selective reduction of nitroarylalkylnitriles with hydrazine and a metal catalyst

Abstract The selectivity in the catalytic reduction of nitroarylalkylnitriles with hydrazine and metal catalysts was studied.

A novel synthesis of tert-leucine via a Leuckart type reaction

An efficient synthesis of racemic tert-leucine from trimethylpyruvic acid using a Leuckart type reaction is described. A facile resolution of an intermediate with α-methylbenzylamine allows entry into either (R)-or (S)-tert-leucine.

An Expeditious Synthesis of 4(5) [3-Aminopropyl] Imidazole

Abstract Inpmmidine 1is a highly potent and selective agonist for histamine receptors.1 The synthesis of inpmnidine and structure activity considerations have recently been described. Inpmmidine also has potential valus for the tEatrnent of catecholamine-insensitive congestive heart failure.3 It has been noted,3 however, that the synthesis of inpromidine is too canplicated and very expensive. One reason for this is the difficulty associated with the synthesis of the crucial inter mxiiate 4(5) [3-aminopmpyl] imidazole 2hereafter referred to as imi damlylpmpylamine.