Brian Morris

G-Protein β3 Subunit Gene (GNB3) Variant in Causation of Essential Hypertension

-Essential hypertensives display enhanced signal transduction through pertussis toxin-sensitive G proteins. The T allele of a C825T variant in exon 10 of the G protein beta3 subunit gene (GNB3) induces formation of a splice variant (Gbeta3-s) with enhanced activity. The T allele of GNB3 was shown recently to be associated with hypertension in unselected German patients (frequency=0.31 versus 0.25 in control). To confirm and extend this finding in a different setting, we performed an association study in Australian white hypertensives. This involved an extensively examined cohort of 110 hypertensives, each of whom were the offspring of 2 hypertensive parents, and 189 normotensives whose parents were both normotensive beyond age 50 years. Genotyping was performed by polymerase chain reaction and digestion with BseDI, which either cut (C allele) or did not cut (T allele) the 268-bp polymerase chain reaction product. T allele frequency in the hypertensive group was 0.43 compared with 0.25 in the normotensive group (chi2=22; P=0.00002; odds ratio=2.3; 95% CI=1.7 to 3.3). The T allele tracked with higher pretreatment blood pressure: diastolic=105+/-7, 109+/-16, and 128+/-28 mm Hg (mean+/-SD) for CC, CT, and TT, respectively (P=0.001 by 1-way ANOVA). Blood pressures were higher in female hypertensives with a T allele (P=0.006 for systolic and 0.0003 for diastolic by ANOVA) than they were in male hypertensives. In conclusion, the present study of a group with strong family history supports a role for a genetically determined, physiologically active splice variant of the G protein beta3 subunit gene in the causation of essential hypertension.

What we talk about when we talk about 'Walking in the City'

Originally published. in France in 1980 (and translated. into English in 1984), Michel de Certeaus The Practice of Everyday Life has assumed. the status of an ur-text for many cultural studies academics and students. In particular, his chapter on ‘Walking in the City’ is often cited. as a blueprint for understanding key terms in the cultural studies repertoire such as ‘power’ and ‘resistance’. This article revisits ‘Walking in the City’ in order to supplement some of the established. understandings of his work circulating in the field of cultural studies, as well as the intersecting fields of cultural geography and urban studies. The paper begins by suggesting ways in which established. understandings of Certeaus work might be usefully rethought and extended. through a consideration of differentiated. instances of walking. Critiquing the account of body-subject relations posited. by Certeau through reference to the writings of Marcel Mauss on techniques of the body and self, the author calls, in particular, for a greater consideration of the role of assemblages and affect in understanding everyday urban practices. By the conclusion of the article, the author arrives at a more nuanced. understanding of the feedback loop between the body-subject and the city, and suggests ways in which Certeaus writing on walking remains productive for those strains of cultural studies interested. in the practices of an increasingly virtualized. urban space.

Un/wrapping Shibuya: Place, media and punctualization

This article discusses cultural studies approaches to the role of media and communication technologies in the constitution of place. The discussion emerges out of the author’s ongoing study of the Shibuya district of Tokyo. Known for its trendsetting youth cultures and as a site of conspicuous consumption, Shibuya is also marked by an unusually intense proliferation of screen technologies, from the large scale (such as television screens embedded in building structures) to the miniature (individual mobile telephone screens). An examination of the articulation of these ubiquitous media technologies with a range of human and institutional actors in Shibuya provides broader insights into contemporary spatial practices and formations. It is argued that a combination of Law’s notion of “punctualization,” drawn from actor-network theory, and Hendy’s social anthropological concept of “un/wrapping” provides a generative framework for conceptualizing and describing the processual production and experience of Shibuya’s mediated place identity.

SCANNING THE GENOME FOR ESSENTIAL HYPERTENSION LOCI

1. Essential hypertension occurs in people with an underlying genetic predisposition who subject themselves to adverse environmental influences. The number of genes involved is unknown, as is the extent to which each contributes to final blood pressure and the severity of the disease.

‘No hugging please, we are Muslims’: Akademi Fantasia, Malay television audiences and the negotiation of global popular cultural forms

This paper analyses the audience reception of the Malaysian reality television programme Akademi Fantasia (AF), which first aired in 2003 and completed its ninth season in 2011. AF has been an influential pioneer in the national television industry, inaugurating the trend of local reality shows and weathering intense competition from similar shows to remain at the top of the ratings chart over the last decade. Based on the Mexican talent search show, La Academia, Malaysias AF is a unique hybrid blend of an Idol-style talent contest and Big Brother observational spectacle. The article draws on primary audience research to investigate the ways in which Malay audiences interpret the potentially incommensurable cultural meanings generated within the context of a localised version of a global television format. Chuas concept of ‘identification and distancing’ is employed as a framework to analyse the complex ways in which perceived Malay ‘cultural norms’ assume primacy as interpretative lenses for audience evaluations of the show and measures of its local difference from similar global cultural products. The research also reveals how these cultural norms are themselves being negotiated by the audience as part of the everyday experience of inhabiting coexisting local and global popular cultural spaces. The analysis focuses on audience understandings and pleasure in the programme in relation to fashion and taste; the behaviour of the official judges; voyeurism and conflict in ‘backstage’ coverage; and emotional intimacy onstage in the public performance component of the programme.

She would say that, he's from Melbourne: fun and games with Dame Edna and Barry Humphries

Abstract This article explores the role that urban place and specifically urban comparison play in the public performances of both the comedian Barry Humphries and the character Edna Everage. In developing Claire Colebrooks analysis of satire as a form of humour that is physically and historically located, we argue that the initial success of Humphries’ satire rests on his elaboration of a specific series of geo-social locations. The article then examines the ways in which Edna makes the local her own global, demonstrating how Barry Humphries has progressively modified and internationalised Ednas provincialism so that his satirical cultural project is understandable over five decades and beyond her origins in Melbourne.