Brian P. Keane

Perceptual Organization Impairment in Schizophrenia and Associated Brain Mechanisms: Review of Research from 2005 to 2010

Perceptual organization (PO) refers to the processes by which visual information is structured into coherent patterns such as groups, contours, perceptual wholes, and object representations. Impairments in PO have been demonstrated in schizophrenia since the 1960s and have been linked to several illness-related factors including poor premorbid functioning, poor prognosis, and disorganized symptoms. This literature was last reviewed in 2005. Since then, electrophysiological (electroencephalographic, event-related potential, and magnetoencephalographic) and fMRI studies in both patient and nonpatient samples have clarified brain mechanisms involved in the impairment, and additional behavioral studies in patients and nonpatients have clarified the computational mechanisms. In addition, data now exist on the functional consequences of PO impairments, in terms of secondary difficulties in face processing, selective attention, working memory, and social cognition. Preliminary data on drug effects on PO and on changes in response to treatment suggest that anomalies in PO may furnish a biomarker for the integrity of its associated biological mechanisms. All of this recent evidence allows for a clearer picture of the nature of the impairment and how it relates to broader aspects of brain and behavioral functioning in schizophrenia.

Is motion extrapolation employed in multiple object tracking? Tracking as a low-level, non-predictive function.

In a series of five experiments, we investigated whether visual tracking mechanisms utilize prediction when recovering multiple reappearing objects. When all objects abruptly disappeared and reappeared mid-trajectory, it was found that (a) subjects tracked better when objects reappeared at their loci of disappearance than when they reappeared in their extrapolated trajectories, (b) disappearance episodes ranging from 150 to 900 ms had virtually no differential effect on performance, (c) tracking deteriorated monotonically as a function of displacement magnitude during disappearance, and (d) tracking did not depend on whether objects moved in predictable paths. Even objects that reappeared backward in their trajectories were tracked dramatically better than objects that reappeared in their extrapolated trajectories. When all objects disappeared and reappeared in ways that implicated the presence of an occluder (i.e., with occlusion and disocclusion cues along fixed contours), tracking again was not predictive, and performance deteriorated with increased displacement. When objects reappeared predictably in 75% of trials, they were still tracked better when they reappeared at their points of disappearance. Theoretical implications of a non-predictive multiple object tracking mechanism are discussed.

Vision Science and Schizophrenia Research: Toward a Re-view of the Disorder Editors’ Introduction to Special Section

This theme section on vision science and schizophrenia research demonstrates that our understanding of the disorder could be significantly accelerated by a greater adoption of the methods of vision science. In this introduction, we briefly describe what vision science is, how it has advanced our understanding of schizophrenia, and what challenges and opportunities lay ahead regarding schizophrenia research. We then summarize the articles that follow. These include reviews of abnormal form perception (perceptual organization and backward masking) and motion processing, and an article on reduced size contrast illusions experienced by hearing but not deaf persons with schizophrenia. These articles reveal that the methods of basic vision research can provide insights into a number of aspects of the disorder, including pathophysiology, development, cognition, social cognition, and phenomenology. Importantly, studies of visual processing in schizophrenia make it clear that there are impairments in the functioning of basic neural mechanisms (e.g., center-surround modulation, contextual modulation of feedforward processing, reentrant processing) that are found throughout the cortex and that are operative in multiple forms of cognitive dysfunction in the illness. Such evidence allows for an updated view of schizophrenia as a condition involving generalized failures in neural network formation and maintenance, as opposed to a primary failure in a higher level factor (e.g., cognitive control) that accounts for all other types of perceptual and cognitive dysfunction. Finally, studies of vision in schizophrenia can identify sensitive probes of neural functioning that can be used as biomarkers of treatment response.

Reduced Depth Inversion Illusions in Schizophrenia Are State-Specific and Occur for Multiple Object Types and Viewing Conditions

Schizophrenia patients are less susceptible to depth inversion illusions (DIIs) in which concave faces appear as convex, but what stimulus attributes generate this effect and how does it vary with clinical state? To address these issues, we had 30 schizophrenia patients and 25 well-matched healthy controls make convexity judgments on physically concave faces and scenes. Patients were selectively sampled from three levels of care to ensure symptom heterogeneity. Half of the concave objects were painted with realistic texture to enhance the convexity illusion; the remaining objects were painted uniform beige to reduce the illusion. Subjects viewed the objects with one eye while laterally moving in front of the stimulus (to see depth via motion parallax) or with two eyes while remaining motionless (to see depth stereoscopically). For each group, DIIs were stronger with texture than without, and weaker with stereoscopic information than without, indicating that patients responded normally to stimulus alterations. More importantly, patients experienced fewer illusions than controls irrespective of the face/scene category, texture, or viewing condition (parallax/stereo). Illusions became less frequent as patients experienced more positive symptoms and required more structured treatment. Taken together, these results indicate that people with schizophrenia experience fewer DIIs with a variety of object types and viewing conditions, perhaps because of a lessened tendency to construe any type of object as convex. Moreover, positive symptoms and the need for structured treatment are associated with more accurate 3-D perception, suggesting that DII may serve as a state marker for the illness.

Optimization and Validation of a Visual Integration Test for Schizophrenia Research

The Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia initiative highlighted a contour integration test as a promising index of visual integration impairment because of its well-established psychometric properties; its prior validation in healthy adults, patients, and nonhuman primates; and its potential sensitivity to treatment effects. In this multisite study, our goals were to validate the task on the largest subject sample to date, clarify the task conditions and number of trials that best discriminate patients from controls, and determine whether this discrimination can occur in standard clinical trial settings. For our task, subjects briefly observed a field of disconnected, oriented elements and attempted to decide whether a subset of those elements formed a leftward- or rightward-pointing shape. Difficulty depended on the amount of orientational jitter that was added to the shapes elements. Two versions of this Jittered Orientation Visual Integration task (JOVI) were examined. Study 1 did not reveal between-group differences in threshold (ie, the jitter magnitude needed to reach a performance level of ∼80%), but this likely owed to the wide sampling distribution of jitter levels and resulting floor/ceiling effects in many conditions. Study 2 incorporated a narrower range of difficulty levels and revealed lower thresholds (worse performance) among patients (p < .001). This group difference remained even when only the first half of the trials was analyzed (p = .001). Thus, the JOVI-2 provides a brief, sensitive measure of visual integration deficits in schizophrenia. Neural implications and potential future applications of the JOVI are discussed.

Effects of short-term inpatient treatment on sensitivity to a size contrast illusion in first-episode psychosis and multiple-episode schizophrenia

Introduction: In the Ebbinghaus illusion, a shape appears larger than its actual size when surrounded by small shapes and smaller than its actual size when surrounded by large shapes. Resistance to this visual illusion has been previously reported in schizophrenia, and linked to disorganized symptoms and poorer prognosis in cross-sectional studies. It is unclear, however, when in the course of illness this resistance first emerges or how it varies longitudinally with illness phase. Method: We addressed these issues by having first-episode psychosis patients, multiple-episode schizophrenia patients and healthy controls complete a psychophysical task at two different time points, corresponding to hospital admission and discharge for patients. The task required judging the relative size of two circular targets centered on either side of the screen. Targets were presented without context (baseline), or were surrounded by shapes that made the size judgment harder or easier (misleading and helpful contexts, respectively). Context sensitivity was operationalized as the amount of improvement relative to baseline in the helpful condition minus the amount of decrement relative to baseline in the misleading condition. Results: At hospital admission, context sensitivity was lower in the multiple-episode group than in the other groups, and was marginally less in the first episode than in the control group. In addition, schizophrenia patients were significantly more and less accurate than the other groups in the misleading and helpful conditions, respectively. At discharge, all groups exhibited similar context sensitivity. In general, poorer context sensitivity was related to higher levels of disorganized symptoms, and lower level of depression, excitement, and positive symptoms. Discussion: Resistance to the Ebbinghaus illusion, as a characteristic of the acute phase of illness in schizophrenia, increases in magnitude after the first episode of psychosis. This suggests that visual context processing is a state-marker in schizophrenia and a biomarker of relapse and recovery.

Interpolation processes in object perception: reply to Anderson (2007).

P. J. Kellman, P. Garrigan, & T. F. Shipley presented a theory of 3-D interpolation in object perception. Along with results from many researchers, this work supports an emerging picture of how the visual system connects separate visible fragments to form objects. In his commentary, B. L. Anderson challenges parts of that view, especially the idea of a common underlying interpolation component in modal and amodal completion (the identity hypothesis). Here the authors analyze Andersons evidence and argue that he neither provides any reason to abandon the identity hypothesis nor offers a viable alternative theory. The authors offer demonstrations and analyses indicating that interpolated contours can appear modally despite absence of the luminance relations, occlusion geometry, and surface attachment that Anderson claims to be necessary. The authors elaborate crossing interpolations as key cases in which modal and amodal appearance must be consequences of interpolation. Finally, the authors dispute Andersons assertion that vision researchers are misguided in using objective performance methods, and they argue that his challenges to relatability fail because contour and surface processes, as well as local and global influences, have been distinguished experimentally.

Cognitive and neuroplasticity mechanisms by which congenital or early blindness may confer a protective effect against schizophrenia.

Several authors have noted that there are no reported cases of people with schizophrenia who were born blind or who developed blindness shortly after birth, suggesting that congenital or early (C/E) blindness may serve as a protective factor against schizophrenia. By what mechanisms might this effect operate? Here, we hypothesize that C/E blindness offers protection by strengthening cognitive functions whose impairment characterizes schizophrenia, and by constraining cognitive processes that exhibit excessive flexibility in schizophrenia. After briefly summarizing evidence that schizophrenia is fundamentally a cognitive disorder, we review areas of perceptual and cognitive function that are both impaired in the illness and augmented in C/E blindness, as compared to healthy sighted individuals. We next discuss: (1) the role of neuroplasticity in driving these cognitive changes in C/E blindness; (2) evidence that C/E blindness does not confer protective effects against other mental disorders; and (3) evidence that other forms of C/E sensory loss (e.g., deafness) do not reduce the risk of schizophrenia. We conclude by discussing implications of these data for designing cognitive training interventions to reduce schizophrenia-related cognitive impairment, and perhaps to reduce the likelihood of the development of the disorder itself.

Perceptual organization in schizophrenia: Plasticity and state-related change

Abstract Perceptual organization (PO) impairments have been repeatedly demonstrated in schizophrenia. The extent to which these impairments can be reduced or eliminated, however, has received less attention, and evidence on this issue has not been previously reviewed. The literature suggests that whether normal experience-dependent change in perceptual organization occurs in schizophrenia depends on factors such as: stimulus grouping strength, extent of practice, type of cues upon which top-down feedback can be generated, and patient characteristics (trait and state). Therefore, the purpose of this paper is to review and synthesize the available evidence on plasticity and other forms of change in PO in schizophrenia, and to relate it to current data and theories on plasticity, including perceptual learning (PL) in healthy people. This can clarify the computational and neural mechanisms involved in experience-dependent and state-related aspects of PO in schizophrenia, and also contribute to a greater under...

Temporal Stability and Moderating Effects of Age and Sex on CNTRaCS Task Performance

Research in schizophrenia has increasingly focused on incorporating measures from cognitive neuroscience, but little is known about their psychometric characteristics. Here, we extend prior research by reporting on temporal stability, as well as age and sex effects, for cognitive neuroscience paradigms optimized as part of the Cognitive Neuroscience Test Reliability and Clinical applications for Schizophrenia consortium. Ninety-nine outpatients with schizophrenia and 131 healthy controls performed 5 tasks assessing 4 constructs at 3 sessions. The constructs were (1) Goal maintenance (Dot Probe Expectancy [DPX] and AX continuous performance tasks [AX-CPT]); (2) Episodic memory (Relational and Item-Specific Encoding and Retrieval task [RiSE]); (3) Visual integration (Jittered Orientation Visual Integration task [JOVI]); and (4) Perceptual gain control (Contrast-Contrast Effect Task [CCE]). Patients performed worse than controls on all but the CCE, and the magnitude of these group differences was stable across sessions, with no sex differences observed. Improvements over sessions were seen for the AX-CPT, the DPX, and the JOVI though practice effects for the AX-CPT and the DPX were primarily present in older participants. For the AX-CPT and the JOVI, practice effects were larger for T1 to T2 than for T2 to T3. Age was associated with poor associative recognition on the RiSE and accuracy on the JOVI. Test-rest reliability ranged from poor for the JOVI threshold score to adequate to good for the DPX, AX-CPT, and JOVI accuracy measures, with RiSE and CCE measures in the moderate range. These results suggest that group differences in DPX, AX-CPT, RiSE, and JOVI are robust and consistent across repeated testing.