Brian Spar | Researchain

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Featured researches published by Brian Spar.

Obesity Research | 2003

Meal Pattern Analysis of Diet‐Induced Obesity in Susceptible and Resistant Rats

Constance Farley; John Cook; Brian Spar; Theodore M. Austin; Timothy J. Kowalski

European Journal of Pharmacology | 2004

Melanin-concentrating hormone-1 receptor antagonism decreases feeding by reducing meal size.

Timothy J. Kowalski; Constance Farley; Mary Cohen-Williams; Geoffrey B. Varty; Brian Spar

Journal of Medicinal Chemistry | 2006

Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas.

McBriar; Henry Guzik; Sherry Shapiro; Jaroslava Paruchova; Ruo Xu; Anandan Palani; John W. Clader; Kathleen Cox; William J. Greenlee; Brian E. Hawes; Timothy J. Kowalski; Kim O'Neill; Brian Spar; Blair Weig; Weston Dj; Constance Farley; John Cook

Journal of Medicinal Chemistry | 2005

Discovery of Bicycloalkyl Urea Melanin Concentrating Hormone Receptor Antagonists: Orally Efficacious Antiobesity Therapeutics

Mark D. McBriar; Henry Guzik; Ruo Xu; Jaroslava Paruchova; Shengjian Li; Anandan Palani; John W. Clader; William J. Greenlee; Brian E. Hawes; Timothy J. Kowalski; Kim O'Neill; Brian Spar; Blair Weig

Journal of Medicinal Chemistry | 2005

Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 antagonists for the treatment of obesity

Anandan Palani; Sherry Shapiro; Mark D. McBriar; John W. Clader; William J. Greenlee; Brian Spar; Timothy J. Kowalski; Constance Farley; John A. Cook; Margaret van Heek; Blair Weig; Kim O'Neill; Michael P. Graziano; Brian E. Hawes

Journal of Endocrinology | 2005

Transgenic overexpression of neuromedin U promotes leanness and hypophagia in mice

Timothy J. Kowalski; Brian Spar; L Markowitz; M Maguire; Andrei Golovko; Shijun Yang; Constance Farley; John Cook; G Tetzloff; Lizbeth Hoos; R. A. Del Vecchio; Tatiana M. Kazdoba; Martha F. McCool; Joyce J. Hwa; Lynn A. Hyde; H Davis; Galya Vassileva; Joseph A. Hedrick; Eric L. Gustafson

European Journal of Pharmacology | 2006

Effects of a selective melanin-concentrating hormone 1 receptor antagonist on food intake and energy homeostasis in diet-induced obese mice

Timothy J. Kowalski; Brian Spar; Blair Weig; Constance Farley; John Cook; Lorraine Ghibaudi; Steve Fried; Kim O'Neill; Robert A. Del Vecchio; Mark D. McBriar; Henry Guzik; John W. Clader; Brian E. Hawes; Joyce J. Hwa

Bioorganic & Medicinal Chemistry | 2006

Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists.

Ruo Xu; Shengjian Li; Jaroslava Paruchova; Mark D. McBriar; Henry Guzik; Anandan Palani; John W. Clader; Kathleen Cox; William J. Greenlee; Brian E. Hawes; Timothy J. Kowalski; Kim O’Neill; Brian Spar; Blair Weig; Daniel J. Weston

Bioorganic & Medicinal Chemistry Letters | 2006

Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists.

Wen-Lian Wu; Duane A. Burnett; Mary Ann Caplen; Martin S. Domalski; Chad E. Bennett; William J. Greenlee; Brian E. Hawes; Kim O’Neill; Blair Weig; Daniel J. Weston; Brian Spar; Timothy J. Kowalski

Bioorganic & Medicinal Chemistry Letters | 2006

Novel aminobenzimidazoles as selective MCH-R1 antagonists for the treatment of metabolic diseases.

Thavalakulamgara K. Sasikumar; Li Qiang; Duane A. Burnett; William J. Greenlee; Brian E. Hawes; Timothy J. Kowalski; Kim O’Neill; Brian Spar; Blair Weig

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